CELR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CELR1_HUMAN
• UniProt AC: Q9NYQ6
• Protein Name: Cadherin EGF LAG seven-pass G-type receptor 1
• Gene Name: CELSR1
• Organism: Homo sapiens (Human).
• Sequence Length: 3014
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor that may have an important role in cell/cell signaling during nervous system formation..
• Protein Sequence: MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVRLRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLTLTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVRTGSAQADGSDSEKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
213	O-linked_Glycosylation	GTPSASPSPSPPLPP CCCCCCCCCCCCCCC	35.20	OGP
215	O-linked_Glycosylation	PSASPSPSPPLPPNL CCCCCCCCCCCCCCC	43.41	OGP
281	Phosphorylation	EGEEERVSYYMEGLF CCCHHHHHHHHCCCC	19.43	-
282	Phosphorylation	GEEERVSYYMEGLFD CCHHHHHHHHCCCCC	12.18	-
283	Phosphorylation	EEERVSYYMEGLFDE CHHHHHHHHCCCCCC	4.91	-
307	Phosphorylation	SATGAVSTDSVLDRE CCCCCCCCCCCCCCC	26.20	22210691
315	Phosphorylation	DSVLDRETKETHVLR CCCCCCCCCCEEEEE	34.77	22210691
356	Phosphorylation	HSPVFEQSEYRERVR CCCCCCCHHHHHHHH	29.42	-
403	N-linked_Glycosylation	AWDVFQLNESSGVVS CEEEEECCCCCCCEE	36.00	UniProtKB CARBOHYD
531	Phosphorylation	FEDVQKYSLSIKAQD HHHHHHEEEEEEECC	23.75	24719451
533	Phosphorylation	DVQKYSLSIKAQDGG HHHHEEEEEEECCCC	18.99	24719451
546	N-linked_Glycosylation	GGRPPLINSSGVVSV CCCCCCCCCCCEEEE	37.49	UniProtKB CARBOHYD
616	Phosphorylation	STFLGGGSAGPKNPA HHCCCCCCCCCCCCC	33.07	27251275
634	N-linked_Glycosylation	DFPFQIHNSSGWITV CCCEEEECCCCEEEE	39.23	UniProtKB CARBOHYD
758	Phosphorylation	DYKQEQQYVLAVTAS CCCCCCEEEEEEECC	9.34	28985074
763	Phosphorylation	QQYVLAVTASDGTRS CEEEEEEECCCCCCC	18.16	28985074
765	Phosphorylation	YVLAVTASDGTRSHT EEEEEECCCCCCCEE	27.49	24043423
768	Phosphorylation	AVTASDGTRSHTAHV EEECCCCCCCEEEEE	33.71	24043423
778	N-linked_Glycosylation	HTAHVLINVTDANTH EEEEEEEECCCCCCC	26.86	UniProtKB CARBOHYD
791	Phosphorylation	THRPVFQSSHYTVSV CCCCCEECCCEEEEE	13.97	27732954
792	Phosphorylation	HRPVFQSSHYTVSVS CCCCEECCCEEEEEE	15.10	27732954
794	Phosphorylation	PVFQSSHYTVSVSED CCEECCCEEEEEECC	15.70	27732954
795	Phosphorylation	VFQSSHYTVSVSEDR CEECCCEEEEEECCC	10.81	27732954
797	Phosphorylation	QSSHYTVSVSEDRPV ECCCEEEEEECCCCC	16.48	27732954
799	Phosphorylation	SHYTVSVSEDRPVGT CCEEEEEECCCCCCC	26.69	27732954
1114	N-linked_Glycosylation	LFNNYVTNKSNSFPT EECCCCCCCCCCCCC	35.40	UniProtKB CARBOHYD
1139	N-linked_Glycosylation	PDVSDSLNYTFVQGN CCCHHHCCEEEECCC	37.44	UniProtKB CARBOHYD
1213	N-linked_Glycosylation	SITVRLENMSQEKFL CEEEEECCCCHHHCH	39.74	UniProtKB CARBOHYD
1249	N-linked_Glycosylation	VFVFNVQNDTDVSSN EEEEEECCCCCCCCC	50.28	UniProtKB CARBOHYD
1259	N-linked_Glycosylation	DVSSNILNVTFSALL CCCCCEEEEEEHHHC	27.30	UniProtKB CARBOHYD
1287	N-linked_Glycosylation	LQEQIYLNRTLLTTI HHHHHHCCCHHHHHH	20.23	UniProtKB CARBOHYD
1326	Phosphorylation	VSVLRFDSSAPFLSS EEEEEECCCCCCCCC	26.20	-
1334	Phosphorylation	SAPFLSSTTVLFRPI CCCCCCCCEEEEEEC	19.97	-
1529	Phosphorylation	VSDGRWHSVQVQYYN CCCCCEEEEEEEEEC	13.79	27050516
1576	N-linked_Glycosylation	RFGKDIGNYSCAAQG ECCCCCCCCCCCCCC	26.36	UniProtKB CARBOHYD
1577	Phosphorylation	FGKDIGNYSCAAQGT CCCCCCCCCCCCCCC	10.42	24667141
1578	Phosphorylation	GKDIGNYSCAAQGTQ CCCCCCCCCCCCCCC	10.98	24667141
1586	Phosphorylation	CAAQGTQTGSKKSLD CCCCCCCCCCCCCCC	43.17	24667141
1588	Phosphorylation	AQGTQTGSKKSLDLT CCCCCCCCCCCCCCC	40.05	24667141
1623	N-linked_Glycosylation	QFVGCMRNLSVDGKN CCCEEEEEEEECCCC	15.13	UniProtKB CARBOHYD
1640	N-linked_Glycosylation	MAGFIANNGTREGCA CEEEECCCCCCCCCC	44.16	UniProtKB CARBOHYD
1666	Hydroxylation	QNGGTCVNRWNMYLC CCCCCEECCCEEEEE	45.45	-
1765	Phosphorylation	DVESVMLSGLRVTDG CHHHHEECCEEECCC	20.06	24719451
1788	Phosphorylation	LKNVKEDSEMKHLVT EECCCCCCHHHHHHH	40.45	26074081
1795	Phosphorylation	SEMKHLVTMTLDYGM CHHHHHHHHHHHCCC	15.70	26074081
1889	Hydroxylation	PPNSRCHDAWEDYSC CCCCCCCCCCCCCCC	57.93	-
1979	N-linked_Glycosylation	KGFDPDCNKTNGQCQ CCCCCCCCCCCCCEE	62.66	UniProtKB CARBOHYD
2103	N-linked_Glycosylation	WLPPELFNCTTISFV CCCHHHHCCEEEEHH	34.55	UniProtKB CARBOHYD
2122	N-linked_Glycosylation	MNEKLSRNETQVDGA HHHHHCCCCCCCCHH	53.98	UniProtKB CARBOHYD
2257	N-linked_Glycosylation	VDIFDKFNFTGARVP HHCHHHCCCCCCCCC	39.03	UniProtKB CARBOHYD
2306	O-linked_Glycosylation	LRPAGRRTTPQTTRP CCCCCCCCCCCCCCC	41.28	55825391
2306	Phosphorylation	LRPAGRRTTPQTTRP CCCCCCCCCCCCCCC	41.28	22210691
2307	O-linked_Glycosylation	RPAGRRTTPQTTRPG CCCCCCCCCCCCCCC	16.16	55825397
2310	O-linked_Glycosylation	GRRTTPQTTRPGPGT CCCCCCCCCCCCCCC	26.44	55825403
2310	Phosphorylation	GRRTTPQTTRPGPGT CCCCCCCCCCCCCCC	26.44	22210691
2311	O-linked_Glycosylation	RRTTPQTTRPGPGTE CCCCCCCCCCCCCCC	29.62	55825409
2317	Phosphorylation	TTRPGPGTEREAPIS CCCCCCCCCCCCCCC	34.70	22210691
2415	N-linked_Glycosylation	KPVCVFWNHSLAVGG CCEEEEECCCEECCC	11.91	UniProtKB CARBOHYD
2417	Phosphorylation	VCVFWNHSLAVGGTG EEEEECCCEECCCCC	18.14	29978859
2435	Phosphorylation	ARGCELLSRNRTHVA HHHHHHHCCCCCEEE	39.88	24719451
2437	N-linked_Glycosylation	GCELLSRNRTHVACQ HHHHHCCCCCEEEEE	50.23	UniProtKB CARBOHYD
2491	Phosphorylation	LVAFVLLSLVRMLRS HHHHHHHHHHHHHHH	22.21	24719451
2523	N-linked_Glycosylation	LVFVIGINQTENPFL CCHHHCCCCCCCHHH	37.19	UniProtKB CARBOHYD
2656	Phosphorylation	GIVSLLRTAFLLLLL HHHHHHHHHHHHHHH	23.02	29083192
2665	Phosphorylation	FLLLLLISATWLLGL HHHHHHHHHHHHHHH	21.44	29083192
2667	Phosphorylation	LLLLISATWLLGLLA HHHHHHHHHHHHHHH	15.17	29083192
2713	Ubiquitination	QEVRKHLKGVLGGRK HHHHHHHCHHHCCCC	46.85	29967540
2720	Ubiquitination	KGVLGGRKLHLEDSA CHHHCCCCEECCCCH	43.46	33845483
2726	Phosphorylation	RKLHLEDSATTRATL CCEECCCCHHHHHHH	20.38	25159151
2728	Phosphorylation	LHLEDSATTRATLLT EECCCCHHHHHHHHH	22.29	25002506
2729	Phosphorylation	HLEDSATTRATLLTR ECCCCHHHHHHHHHH	20.30	25002506
2737	Phosphorylation	RATLLTRSLNCNTTF HHHHHHHHCCCCCCC	20.78	28857561
2742	Phosphorylation	TRSLNCNTTFGDGPD HHHCCCCCCCCCCCC	26.21	21712546
2743	Phosphorylation	RSLNCNTTFGDGPDM HHCCCCCCCCCCCCC	16.19	21712546
2753	Phosphorylation	DGPDMLRTDLGESTA CCCCCEECCCCCCCC	31.45	20639409
2758	Phosphorylation	LRTDLGESTASLDSI EECCCCCCCCCHHHH	27.72	30278072
2759	Phosphorylation	RTDLGESTASLDSIV ECCCCCCCCCHHHHH	18.90	33259812
2761	Phosphorylation	DLGESTASLDSIVRD CCCCCCCCHHHHHHC	32.56	30278072
2764	Phosphorylation	ESTASLDSIVRDEGI CCCCCHHHHHHCCCH	28.42	30278072
2773	Ubiquitination	VRDEGIQKLGVSSGL HHCCCHHHHCCCCCC	45.33	29901268
2777	Phosphorylation	GIQKLGVSSGLVRGS CHHHHCCCCCCCCCC	19.52	29214152
2778	Phosphorylation	IQKLGVSSGLVRGSH HHHHCCCCCCCCCCC	33.47	28555341
2784	Phosphorylation	SSGLVRGSHGEPDAS CCCCCCCCCCCCCCC	20.11	23898821
2791	Phosphorylation	SHGEPDASLMPRSCK CCCCCCCCCCCCCCC	32.36	28555341
2867	Phosphorylation	PAGWPDQSLAESDSE CCCCCCHHHCCCCCC	36.61	23927012
2871	Phosphorylation	PDQSLAESDSEDPSG CCHHHCCCCCCCCCC	40.61	25159151
2873	Phosphorylation	QSLAESDSEDPSGKP HHHCCCCCCCCCCCC	53.85	23663014
2877	Phosphorylation	ESDSEDPSGKPRLKV CCCCCCCCCCCCEEE	72.30	23663014
2889	Phosphorylation	LKVETKVSVELHREE EEEEEEEEEEEEHHC	16.07	23898821
2960	Phosphorylation	KLADCEQSPTSSRTS HHHCCCCCCCCCCCC	14.09	29255136
2962	Phosphorylation	ADCEQSPTSSRTSSL HCCCCCCCCCCCCCC	44.58	29255136
2963	Phosphorylation	DCEQSPTSSRTSSLG CCCCCCCCCCCCCCC	22.62	29255136
2964	Phosphorylation	CEQSPTSSRTSSLGS CCCCCCCCCCCCCCC	41.89	29255136
2966	Phosphorylation	QSPTSSRTSSLGSGG CCCCCCCCCCCCCCC	25.31	29514088
2967	Phosphorylation	SPTSSRTSSLGSGGP CCCCCCCCCCCCCCC	23.58	29514088
2968	Phosphorylation	PTSSRTSSLGSGGPD CCCCCCCCCCCCCCC	35.82	29514088
2971	Phosphorylation	SRTSSLGSGGPDCAI CCCCCCCCCCCCEEE	45.96	24719451
2982	Phosphorylation	DCAITVKSPGREPGR CEEEEECCCCCCCCC	28.40	20363803
3001	Phosphorylation	GVAMNVRTGSAQADG CEEEEEECCCCCCCC	31.07	22210691
3003	Phosphorylation	AMNVRTGSAQADGSD EEEEECCCCCCCCCC	19.32	27251275
3009	Phosphorylation	GSAQADGSDSEKP-- CCCCCCCCCCCCC--	38.21	30576142
3011	Phosphorylation	AQADGSDSEKP---- CCCCCCCCCCC----	49.57	25106551

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CELR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CELR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CELR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP_HUMAN	PSAP	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 182940: Neural tube defects (NTD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2761 AND SER-2764, ANDMASS SPECTROMETRY.
PubMed: 18669648