H6ST1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H6ST1_HUMAN
• UniProt AC: O60243
• Protein Name: Heparan-sulfate 6-O-sulfotransferase 1
• Gene Name: HS6ST1
• Organism: Homo sapiens (Human).
• Sequence Length: 411
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid..
• Protein Sequence: MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	O-linked_Glycosylation	DDLDLFPTPDPHYEK CCCCCCCCCCCCCCC	32.75	OGP
123	Ubiquitination	CDCRPGQKKCTCYRP CCCCCCCCEEEEECC	56.59	-
179	Phosphorylation	LRTPRKFYYITLLRD HCCCCEEEEEEEECC	9.29	28509920
180	Phosphorylation	RTPRKFYYITLLRDP CCCCEEEEEEEECCH	7.20	28509920
264	N-linked_Glycosylation	LSLVGCYNLSFIPEG HHEEEEEEEECCCCC	33.03	UniProtKB CARBOHYD
320	N-linked_Glycosylation	IRPFMQYNSTRAGGV HHHHHCCCCCCCCCC	21.73	UniProtKB CARBOHYD
400	O-linked_Glycosylation	DEPGRVPTEDYMSHI CCCCCCCCHHHHHHH	38.34	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H6ST1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H6ST1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H6ST1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of H6ST1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.