NETO2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NETO2_HUMAN
• UniProt AC: Q8NC67
• Protein Name: Neuropilin and tolloid-like protein 2
• Gene Name: NETO2
• Organism: Homo sapiens (Human).
• Sequence Length: 525
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity)..
• Protein Sequence: MALERLCSVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGVFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEISADLADLSEELDNYQKMRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQGHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
125	Ubiquitination	IDRYCGVKSPPLIRS HHHHCCCCCCCEEEE	42.39	-
200	Ubiquitination	VEQEEKTKPGQAVDC HCCCCCCCCCCEEEE	59.21	-
231	Phosphorylation	LDYQMEHSNECKRNF HHHHHHCCCCCCCCE	22.48	22210691
235	Ubiquitination	MEHSNECKRNFVAVY HHCCCCCCCCEEEEE	44.17	-
254	Ubiquitination	SIENLKAKFCSTVAN HHHHHHHHHHHHHHH	45.37	-
257	Phosphorylation	NLKAKFCSTVANDVM HHHHHHHHHHHHHHH	29.11	-
311	N-linked_Glycosylation	CHSNMCINNSLVCNG ECCCEEECCCEEECC	27.40	UniProtKB CARBOHYD
336	Methylation	NHCKEKKKAGVFEQI CHHCHHHHHCHHHHH	62.53	-
344	Phosphorylation	AGVFEQITKTHGTII HCHHHHHHHHCCCHH	29.59	28464451
381	Ubiquitination	RKKVMACKTAFNKTG CHHHHHCCCHHHHCC	33.09	-
382	Phosphorylation	KKVMACKTAFNKTGF HHHHHCCCHHHHCCH	36.04	21712546
386	Ubiquitination	ACKTAFNKTGFQEVF HCCCHHHHCCHHHHC	43.50	-
398	Phosphorylation	EVFDPPHYELFSLRD HHCCCCCEEEEECCC	21.79	25884760
402	Phosphorylation	PPHYELFSLRDKEIS CCCEEEEECCCHHHC	34.81	26356563
406	Ubiquitination	ELFSLRDKEISADLA EEEECCCHHHCHHHH	50.98	-
409	Phosphorylation	SLRDKEISADLADLS ECCCHHHCHHHHHHH	19.47	24850871
416	Phosphorylation	SADLADLSEELDNYQ CHHHHHHHHHHHHHH	29.58	-
422	Phosphorylation	LSEELDNYQKMRRSS HHHHHHHHHHHHHHC	14.80	25884760
432	Phosphorylation	MRRSSTASRCIHDHH HHHHCHHHHHHCCCC	27.98	22798277
442	Phosphorylation	IHDHHCGSQASSVKQ HCCCCCCCCHHHHHH	28.15	29449344
445	Phosphorylation	HHCGSQASSVKQSRT CCCCCCHHHHHHHCC	28.20	29449344
446	Phosphorylation	HCGSQASSVKQSRTN CCCCCHHHHHHHCCC	36.03	29449344
452	Phosphorylation	SSVKQSRTNLSSMEL HHHHHHCCCCCCCCC	45.84	28111955
455	Phosphorylation	KQSRTNLSSMELPFR HHHCCCCCCCCCCCC	29.70	28111955
456	O-linked_Glycosylation	QSRTNLSSMELPFRN HHCCCCCCCCCCCCC	21.31	29351928
456	Phosphorylation	QSRTNLSSMELPFRN HHCCCCCCCCCCCCC	21.31	28111955
473	Phosphorylation	AQPQPMKTFNSTFKK CCCCCCCCCCHHCCC	23.07	28348404
476	Phosphorylation	QPMKTFNSTFKKSSY CCCCCCCHHCCCCCC	30.91	28348404
477	Phosphorylation	PMKTFNSTFKKSSYT CCCCCCHHCCCCCCC	40.35	28348404
486	Ubiquitination	KKSSYTFKQGHECPE CCCCCCCCCCCCCHH	47.79	-
509	Phosphorylation	EEIPCEIYVRGREDS HHCCCEEEECCCCCC	2.18	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NETO2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NETO2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NETO2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C17_HUMAN	KRT17	physical	26496610
TIA1_HUMAN	TIA1	physical	26496610
AIMP2_HUMAN	AIMP2	physical	26496610
IRS2_HUMAN	IRS2	physical	26496610
WDHD1_HUMAN	WDHD1	physical	26496610
NELFD_HUMAN	NELFCD	physical	26496610
TRM6_HUMAN	TRMT6	physical	26496610
TM168_HUMAN	TMEM168	physical	26496610
CCD82_HUMAN	CCDC82	physical	26496610
H6ST2_HUMAN	HS6ST2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.