TM168_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM168_HUMAN
• UniProt AC: Q9H0V1
• Protein Name: Transmembrane protein 168
• Gene Name: TMEM168
• Organism: Homo sapiens (Human).
• Sequence Length: 697
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MCKSLRYCFSHCLYLAMTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTANSLILVIFILGLFVLGIASILYYYFSMEAASLSLSNLWFGFLLGLLCFLDNSSFKNDVKEESTKYLLLTSIVLRILCSLVERISGYVRHRPTLLTTVEFLELVGFAIASTTMLVEKSLSVILLVVALAMLIIDLRMKSFLAIPNLVIFAVLLFFSSLETPKNPIAFACFFICLITDPFLDIYFSGLSVTERWKPFLYRGRICRRLSVVFAGMIELTFFILSAFKLRDTHLWYFVIPGFSIFGIFWMICHIIFLLTLWGFHTKLNDCHKVYFTHRTDYNSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVGYAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGPRHDTYILYYSGHTHGTGEWALAGGDTLRLDTLIEWWREKNGSFCSRLIIVLDSENSTPWVKEVRKINDQYIAVQGAELIKTVDIEEADPPQLGDFTKDWVEYNCNSSNNICWTEKGRTVKAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRITYPLVHLANWLCGLNLFWICKTCFRCLKRLKMSWFLPTVLDTGQGFKLVKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	NREVNMHSSVRYLGY HHHCCCCHHHHHHHH	21.54	-
35	Phosphorylation	NMHSSVRYLGYLARI CCCHHHHHHHHHHHH	11.43	24043423
38	Phosphorylation	SSVRYLGYLARINLL HHHHHHHHHHHHHHH	8.46	24043423
53	Phosphorylation	VAICLGLYVRWEKTA HHHHHHHHHHHHHHH	6.03	24043423
111	N-linked_Glycosylation	GLLCFLDNSSFKNDV HHHHHHCCCCCCCCC	41.52	UniProtKB CARBOHYD
125	Phosphorylation	VKEESTKYLLLTSIV CCHHHHHHHHHHHHH	11.58	24505115
198	Phosphorylation	IIDLRMKSFLAIPNL HHHHHHHHHCCCHHH	19.02	-
219	Phosphorylation	LFFSSLETPKNPIAF HHHHCCCCCCCHHHH	44.87	21964256
253	Ubiquitination	LSVTERWKPFLYRGR CCCHHCCCCCHHHCH	31.92	-
276	Phosphorylation	FAGMIELTFFILSAF HHHHHHHHHHHHHHH	12.05	-
281	Phosphorylation	ELTFFILSAFKLRDT HHHHHHHHHHCCCCC	27.18	-
330	Phosphorylation	LNDCHKVYFTHRTDY HHCCCEEEEECCCCH	13.94	-
337	Phosphorylation	YFTHRTDYNSLDRIM EEECCCCHHHHHHHH	13.16	-
339	Phosphorylation	THRTDYNSLDRIMAS ECCCCHHHHHHHHHC	25.97	-
346	Phosphorylation	SLDRIMASKGMRHFC HHHHHHHCCCCCCHH	16.62	-
445	Phosphorylation	QELNLRSTGMLNAIQ HHCCCCCCCHHHHHH	21.85	-
533	N-linked_Glycosylation	IEWWREKNGSFCSRL HHHHHHHCCCCCEEE	46.73	UniProtKB CARBOHYD
535	Phosphorylation	WWREKNGSFCSRLII HHHHHCCCCCEEEEE	32.26	-
598	N-linked_Glycosylation	DWVEYNCNSSNNICW CCHHHCCCCCCCEEE	44.85	UniProtKB CARBOHYD
623	Phosphorylation	YGVSKRWSDYTLHLP EECCCCCCCEEEECC	25.44	24961811
625	Phosphorylation	VSKRWSDYTLHLPTG CCCCCCCEEEECCCC	12.99	-
626	Phosphorylation	SKRWSDYTLHLPTGS CCCCCCEEEECCCCC	16.82	-
631	Phosphorylation	DYTLHLPTGSDVAKH CEEEECCCCCHHHHH	56.53	-
679	Phosphorylation	CLKRLKMSWFLPTVL HHHHHCHHHCCCEEE	17.06	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM168_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM168_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM168_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM168_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.