dbPTM

T131L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	T131L_HUMAN
UniProt AC	A2VDJ0
Protein Name	Transmembrane protein 131-like {ECO:0000312\|HGNC:HGNC:29146}
Gene Name	TMEM131L {ECO:0000312\|HGNC:HGNC:29146}
Organism	Homo sapiens (Human).
Sequence Length	1609
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Cytoplasm . During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially
Protein Description	Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation..
Protein Sequence	MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGELLLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RRPQPGCYCRTAAAV CCCCCCCCHHHHHHH	7.29	-
122	Phosphorylation	AYNPSRDSEVVVNSV HHCCCCCCCHHHHHH	31.05	-
151	Ubiquitination	RVIPAMGKTSFRIIF EEECCCCCCEEEEEE	28.10	-
199	Ubiquitination	ISTEGSAKQLPNAYF ECCCCCHHHCCCEEE	54.81	-
246	Ubiquitination	NKVCQQLKGCYLESD HHHHHHCCCCCCCCC	42.47	-
343	N-linked_Glycosylation	LLPTSTTNFTKIASF ECCCCCCCCEEEEEE	42.55	UniProtKB CARBOHYD
353	Ubiquitination	KIASFTCKATSCDSG EEEEEEECCCCCCCC	52.20	-
353 (in isoform 3)	Ubiquitination	-	52.20	-
353 (in isoform 5)	Ubiquitination	-	52.20	-
366	Ubiquitination	SGIIEDVKKTTHTPT CCCCCCHHHHCCCCH	57.64	-
367 (in isoform 3)	Ubiquitination	-	59.51	-
367 (in isoform 5)	Ubiquitination	-	59.51	-
368	Phosphorylation	IIEDVKKTTHTPTLK CCCCHHHHCCCCHHH	20.35	-
368 (in isoform 3)	Ubiquitination	-	20.35	-
368 (in isoform 5)	Ubiquitination	-	20.35	-
369	Phosphorylation	IEDVKKTTHTPTLKA CCCHHHHCCCCHHHH	32.41	-
371	Phosphorylation	DVKKTTHTPTLKACL CHHHHCCCCHHHHHH	18.84	-
373	Phosphorylation	KKTTHTPTLKACLFS HHHCCCCHHHHHHHH	41.88	-
439	N-linked_Glycosylation	KHMLKILNFTGPLFL HHHHHHHHCCCCCCC	35.59	UniProtKB CARBOHYD
492	Phosphorylation	LQIYSAPTKEGSLGF EEEEECCCCCCCCCH	41.25	-
509	Phosphorylation	IAHCGMHYFMGKSKA EECCCCEECCCCCCC	6.08	-
522	N-linked_Glycosylation	KAGNPNWNGSLSLDQ CCCCCCCCCCCCCCC	36.49	UniProtKB CARBOHYD
547	Acetylation	NKLYERWKKYKNGDV HHHHHHHHHHCCCCC	53.07	20167786
569	Acetylation	TTRFAHLKKSKESES CCCCCHHCCCCCCCC	45.17	20167786
572	Ubiquitination	FAHLKKSKESESFVF CCHHCCCCCCCCCEE	74.31	-
574	Phosphorylation	HLKKSKESESFVFFL HHCCCCCCCCCEEHH	42.13	26699800
576	Phosphorylation	KKSKESESFVFFLPR CCCCCCCCCEEHHHH	35.67	26699800
593	N-linked_Glycosylation	AEPGLMLNFSATALR CCCCEECCCCHHHHH	18.18	UniProtKB CARBOHYD
614	Phosphorylation	FVVQNPSSWPVSLQL EEEECCCCCCEEEEE	36.33	23917254
618	Phosphorylation	NPSSWPVSLQLLPLS CCCCCCEEEEEEEHH	13.30	23917254
625	Phosphorylation	SLQLLPLSLYPKPEA EEEEEEHHHCCCHHH	24.74	23917254
627	Phosphorylation	QLLPLSLYPKPEALV EEEEHHHCCCHHHHH	13.06	23917254
686	Ubiquitination	HLQPLEMKRVGVVFT ECCCCCCCEEEEEEC	34.26	-
699	Ubiquitination	FTPADYGKVTSLILI ECHHHHCCEEEEEEE	35.79	-
702	Phosphorylation	ADYGKVTSLILIRNN HHHCCEEEEEEEECC	19.19	24719451
709	N-linked_Glycosylation	SLILIRNNLTVIDMI EEEEEECCCEEEECC	27.52	UniProtKB CARBOHYD
728	Ubiquitination	FGARELLKVGGRLPG CCHHHHHHCCCCCCC	52.00	-
729 (in isoform 5)	Ubiquitination	-	11.23	-
743	Ubiquitination	AGGSLRFKVPESTLM CCCCCEEECCHHHHH	50.90	-
757	Ubiquitination	MDCRRQLKDSKQILS HHHHHHHCCHHHHHH	52.17	-
760	Ubiquitination	RRQLKDSKQILSITK HHHHCCHHHHHHHCC	52.03	-
764	Phosphorylation	KDSKQILSITKNFKV CCHHHHHHHCCCEEE	29.82	24719451
767	Ubiquitination	KQILSITKNFKVENI HHHHHHCCCEEEEEC	59.73	-
770	Ubiquitination	LSITKNFKVENIGPL HHHCCCEEEEECCCC	59.02	-
846	N-linked_Glycosylation	LEFRFTLNVTLPHHL EEEEEEEEEECCCHH	22.97	UniProtKB CARBOHYD
903	Phosphorylation	ILMEFMKTRQRQNAS HHHHHHHHHHHHHCC	21.90	22210691
933	Acetylation	HSYKSNCKNFLDTYG CHHHHCCCCHHHHCC	55.79	19820777
933	Ubiquitination	HSYKSNCKNFLDTYG CHHHHCCCCHHHHCC	55.79	-
938	Phosphorylation	NCKNFLDTYGPSDKG CCCCHHHHCCCCCCC	32.31	28796482
939	Phosphorylation	CKNFLDTYGPSDKGR CCCHHHHCCCCCCCC	27.06	28796482
940	Phosphorylation	KNFLDTYGPSDKGRG CCHHHHCCCCCCCCC	19.82	27642862
942	Phosphorylation	FLDTYGPSDKGRGKN HHHHCCCCCCCCCCC	47.82	28796482
944	Ubiquitination	DTYGPSDKGRGKNCL HHCCCCCCCCCCCCC	55.64	-
955	Phosphorylation	KNCLPVNTPQSRIQN CCCCCCCCCHHHHHH	23.96	25159151
967	Phosphorylation	IQNAAKRSPATYGHS HHHHHHHCCCCCCCC	20.41	29978859
970	Phosphorylation	AAKRSPATYGHSQKK HHHHCCCCCCCCCCC	33.16	29978859
971	Phosphorylation	AKRSPATYGHSQKKH HHHCCCCCCCCCCCE	18.23	29978859
972	Phosphorylation	KRSPATYGHSQKKHK HHCCCCCCCCCCCEE	15.04	27642862
974	Phosphorylation	SPATYGHSQKKHKCS CCCCCCCCCCCEECE	39.05	29978859
981	Phosphorylation	SQKKHKCSVYYSKHK CCCCEECEEEECCCC	20.25	-
983	Phosphorylation	KKHKCSVYYSKHKTS CCEECEEEECCCCCC	5.92	-
989	Phosphorylation	VYYSKHKTSTAAASS EEECCCCCCCCCCCC	30.91	-
990	Phosphorylation	YYSKHKTSTAAASST EECCCCCCCCCCCCC	22.35	-
991	Phosphorylation	YSKHKTSTAAASSTS ECCCCCCCCCCCCCC	26.08	-
1004	Ubiquitination	TSTTTEEKQTSPLGS CCCCCCCCCCCCCCC	53.28	-
1007	Phosphorylation	TTEEKQTSPLGSSLP CCCCCCCCCCCCCCC	18.68	25159151
1017	Ubiquitination	GSSLPAAKEDICTDA CCCCCCHHHHHCCHH	59.01	-
1022	Phosphorylation	AAKEDICTDAMRENW CHHHHHCCHHHHHCH	27.42	28674151
1036	Phosphorylation	WISLRYASGINVNLQ HHHEEECCCCCCEEC	31.13	28555341
1044	Ubiquitination	GINVNLQKNLTLPKN CCCCEECCCCCCCHH	58.03	-
1055	Ubiquitination	LPKNLLNKEENTLKN CCHHHCCCCCCCCCC	67.39	-
1059	Phosphorylation	LLNKEENTLKNTIVF HCCCCCCCCCCEEEE	42.25	-
1076	Ubiquitination	PSSECSMKEGIQTCM CCCCCCCCCCCCCCC	36.17	-
1092	Phosphorylation	PKETDIKTSENTAEF CCCCCCCCCCCCHHH	41.42	29449344
1093	Phosphorylation	KETDIKTSENTAEFK CCCCCCCCCCCHHHH	24.69	29449344
1096	Phosphorylation	DIKTSENTAEFKERE CCCCCCCCHHHHHHH	24.42	29449344
1112	Ubiquitination	CPLKTSKKLPENHLP CCCCCCCCCCCCCCC	69.87	-
1122	Phosphorylation	ENHLPRNSPQYHQPD CCCCCCCCCCCCCCC	18.05	25159151
1123	Phosphorylation	NHLPRNSPQYHQPDL CCCCCCCCCCCCCCC	42.15	27642862
1125	Phosphorylation	LPRNSPQYHQPDLPE CCCCCCCCCCCCCHH	13.05	28796482
1126	Phosphorylation	PRNSPQYHQPDLPEI CCCCCCCCCCCCHHH	27.70	27642862
1212	Phosphorylation	NLQNLNWSKSRTCRK CCCCCCCCCCHHHCC	21.49	25159151
1242	Phosphorylation	SDLKLVCSDFERSEL CCCEEEECHHCHHHC	37.54	-
1269	Ubiquitination	ESTREVCKADAEIAS HHHHHHHHHHHHHHH	55.25	-
1276	Phosphorylation	KADAEIASSLPAAQR HHHHHHHHCCCHHHH	37.76	23322592
1277	Phosphorylation	ADAEIASSLPAAQRE HHHHHHHCCCHHHHH	29.38	29978859
1288	Phosphorylation	AQREAEGYYQKPEKK HHHHHCCCCCCCCCH	8.33	28796482
1289	Phosphorylation	QREAEGYYQKPEKKC HHHHCCCCCCCCCHH	22.40	28796482
1290	Phosphorylation	REAEGYYQKPEKKCV HHHCCCCCCCCCHHH	46.47	27642862
1302	Phosphorylation	KCVDKFCSDSSSDCG HHHHHHCCCCCCCCC	43.59	26471730
1304	Phosphorylation	VDKFCSDSSSDCGSS HHHHCCCCCCCCCCC	18.56	27251275
1305	Phosphorylation	DKFCSDSSSDCGSSS HHHCCCCCCCCCCCC	34.88	27251275
1306	Phosphorylation	KFCSDSSSDCGSSSG HHCCCCCCCCCCCCC	40.65	26471730
1307	Phosphorylation	FCSDSSSDCGSSSGS HCCCCCCCCCCCCCC	42.62	27251275
1310	Phosphorylation	DSSSDCGSSSGSVRA CCCCCCCCCCCCCEE	27.88	26471730
1311	Phosphorylation	SSSDCGSSSGSVRAS CCCCCCCCCCCCEEC	24.81	27251275
1312	Phosphorylation	SSDCGSSSGSVRASR CCCCCCCCCCCEECC	36.46	27251275
1321	Phosphorylation	SVRASRGSWGSWSST CCEECCCCCCCCCCC	27.44	25159151
1324	Phosphorylation	ASRGSWGSWSSTSSS ECCCCCCCCCCCCCC	19.95	19690332
1327	Phosphorylation	GSWGSWSSTSSSDGD CCCCCCCCCCCCCCC	26.50	-
1328	Phosphorylation	SWGSWSSTSSSDGDK CCCCCCCCCCCCCCC	27.41	19690332
1330	Phosphorylation	GSWSSTSSSDGDKKP CCCCCCCCCCCCCCC	32.32	19690332
1331	Phosphorylation	SWSSTSSSDGDKKPM CCCCCCCCCCCCCCC	45.43	19690332
1524	Phosphorylation	SPPYLTSTRSLSPMS CCCCCCCCCCCCCCC	21.02	26074081
1526	Phosphorylation	PYLTSTRSLSPMSGL CCCCCCCCCCCCCCC	33.03	26074081
1528	Phosphorylation	LTSTRSLSPMSGLFG CCCCCCCCCCCCCCC	21.58	26074081
1571	Phosphorylation	QAVVCKEYYPGFNPF CEEEECCCCCCCCHH	10.64	28796482
1572	Phosphorylation	AVVCKEYYPGFNPFR EEEECCCCCCCCHHH	9.66	28796482
1600	Phosphorylation	RNANFPLSRDSSYCG CCCCCCCCCCCCCCC	33.99	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of T131L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of T131L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of T131L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of T131L_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of T131L_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1122, AND MASSSPECTROMETRY.	18669648 [Abstract]