dbPTM

RGPA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RGPA1_HUMAN
UniProt AC	Q6GYQ0
Protein Name	Ral GTPase-activating protein subunit alpha-1
Gene Name	RALGAPA1
Organism	Homo sapiens (Human).
Sequence Length	2036
Subcellular Localization	Cytoplasm. Nucleus. Translocated to the nucleus, when associated with TCF3/E12..
Protein Description	Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB..
Protein Sequence	MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTIEASLKQKGHKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKIRREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGFSAPQSEHGPRTLDNLINPPLNLQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSFLFSHFKKYYLPYIFPNICKENSLYHPILDIPQMRPKPHYVVIKKDAETNEAIYCTKEPFIKARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDRTTEPEQSHSNTSTLTEREPSSSSLCSIDEEHLTDIEIVRRVFSSKRSNVNFVTEIFRQAFLLPICEAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGEKREEENGTNTADHVRNSSWAKNGSYQGALHNASEEATEQNIRAGTQAVLQVFIINSSNIFLLEPANEIKNLLDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTESVLKMPSQAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSLTYWEELATEWSLTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQKVSVDKSFSRGWSRDQPGQAPMRQRSATTTGSPGTEKARSIVRQKTVDIDDAQILPRSTRVRHFSQSEETGNEVFGALNEEQPLPRSSSTSDILEPFTVERAKVNKEDMSQKLPPLNSDIGGSSANVPDLMDEFIAERLRSGNASTMTRRGSSPGSLEIPKDLPDILNKQNQMRPIDDPGVPSEWTSPASAGSSDLISSDSHSDSFSAFQYDGRKFDNFGFGTDTGVTSSADVDSGSGHHQSAEEQEVASLTTLHIDSETSSLNQQAFSAEVATITGSESASPVHSPLGSRSQTPSPSTLNIDHMEQKDLQLDEKLHHSVLQTPDDLEISEFPSECCSVMAGGTLTGWHADVATVMWRRMLGILGDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNLTSPSPPVLIPPLRILTPWLFKATMLTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHIDQDIVNTIIKHCSPQFFSLGLPGATMLIMDFIVAAGRVASSAFLNAPRVEAQVLLGSLVCFPNLYCELPSLHPNIPDVAVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEELVHESHHPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYVPRLQIYQPDSPLKIIQILIATITHLLPSTEASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPFHATGAESDKTEKSVLNCIYKVLHGCVYGAQCFSNPRYFPMSLSDLASVDYDPFMHLESLKEPEPLHSPDSERSSKLQPVTEVKTQMQHGLISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHDNHYSESTELSPELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANSNVRIIVRDLSGKYSWDSAILYGPPPVSGLSEPTSFMLSLSHQEKPEEPPTSNECLEDITVKDGLSLQFKRFRETVPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPVCISEKQENDVINAILKQHTEEKEFVEKHFNDLNMKAVEQDEPIPQKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLFDGAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFEDFAAQVFSPAPYHHLPSDADH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MFSKKPHGDV -----CCCCCCCCCC	52.18	26074081
13	Phosphorylation	PHGDVKKSTQKVLDT CCCCCCHHHHHHHHC	30.28	26074081
14	Phosphorylation	HGDVKKSTQKVLDTK CCCCCHHHHHHHHCC	41.09	26074081
20	Phosphorylation	STQKVLDTKKDALTR HHHHHHHCCHHHHHH	35.51	26074081
40	Phosphorylation	IVIENAESIDLKQFF HEEECCCCCCHHHHH	20.99	24961811
118	Phosphorylation	ILKKLLHTGNSLKIR HHHHHHHCCCCHHHH	37.72	22210691
121	Phosphorylation	KLLHTGNSLKIRREG HHHHCCCCHHHHHHH	32.17	22210691
152	Phosphorylation	KEQLWMFSCLIPGFS HHHHHHHHCCCCCCC	7.60	28188228
163	Phosphorylation	PGFSAPQSEHGPRTL CCCCCCCCCCCCCCH	30.42	28188228
292	Phosphorylation	AETNEAIYCTKEPFI CCCCCCEEECCCHHH	10.91	24114839
295	Ubiquitination	NEAIYCTKEPFIKAR CCCEEECCCHHHHHH	60.88	-
342	Phosphorylation	NIQRAAASLVSREES HHHHHHHHHHCCHHH	25.28	28258704
345	Phosphorylation	RAAASLVSREESKND HHHHHHHCCHHHCCC	38.99	25159151
349	Phosphorylation	SLVSREESKNDNADK HHHCCHHHCCCCCCC	31.82	25159151
360	Phosphorylation	NADKTDRTTEPEQSH CCCCCCCCCCCCCCC	38.02	27732954
361	Phosphorylation	ADKTDRTTEPEQSHS CCCCCCCCCCCCCCC	50.89	27732954
366	Phosphorylation	RTTEPEQSHSNTSTL CCCCCCCCCCCCCCC	27.50	27732954
368	Phosphorylation	TEPEQSHSNTSTLTE CCCCCCCCCCCCCCC	47.23	25849741
370	Phosphorylation	PEQSHSNTSTLTERE CCCCCCCCCCCCCCC	26.55	27732954
371	Phosphorylation	EQSHSNTSTLTEREP CCCCCCCCCCCCCCC	26.18	23927012
372	Phosphorylation	QSHSNTSTLTEREPS CCCCCCCCCCCCCCC	35.34	27732954
374	Phosphorylation	HSNTSTLTEREPSSS CCCCCCCCCCCCCCC	32.84	27732954
379	Phosphorylation	TLTEREPSSSSLCSI CCCCCCCCCCCCCCC	37.79	23663014
380	Phosphorylation	LTEREPSSSSLCSID CCCCCCCCCCCCCCC	34.36	23663014
381	Phosphorylation	TEREPSSSSLCSIDE CCCCCCCCCCCCCCH	31.50	23663014
382	Phosphorylation	EREPSSSSLCSIDEE CCCCCCCCCCCCCHH	35.03	23663014
385	Phosphorylation	PSSSSLCSIDEEHLT CCCCCCCCCCHHHCC	38.07	23663014
392	Phosphorylation	SIDEEHLTDIEIVRR CCCHHHCCHHHHHHH	36.52	23663014
469	Phosphorylation	LPCIENVTDHDISME CCCEECCCCCCCCHH	38.92	28102081
474	Phosphorylation	NVTDHDISMEEGEKR CCCCCCCCHHHHCHH	26.63	25159151
497	Phosphorylation	ADHVRNSSWAKNGSY HHHHHCCHHHHCCCC	34.30	24719451
503	Phosphorylation	SSWAKNGSYQGALHN CHHHHCCCCCHHCCC	24.55	26657352
504	Phosphorylation	SWAKNGSYQGALHNA HHHHCCCCCHHCCCC	16.62	30108239
512	Phosphorylation	QGALHNASEEATEQN CHHCCCCCHHHHHHH	41.09	30108239
516	Phosphorylation	HNASEEATEQNIRAG CCCCHHHHHHHHHHH	41.19	23312004
598	Phosphorylation	ESVLKMPSQAFLQFQ HHHHHCCCHHHHHCC	30.55	-
611	Phosphorylation	FQGKKNMTLAGRLAG CCCCCCCCHHHHHHH	23.89	23312004
679	Phosphorylation	VLARNLYSLDLSDLP HHHHHCCCCCCCCCC	20.69	28348404
689	Ubiquitination	LSDLPLDKLSEQKQK CCCCCHHHHHHHHHH	62.69	-
691	Phosphorylation	DLPLDKLSEQKQKKH CCCHHHHHHHHHHHH	43.66	25159151
711	Phosphorylation	GHEFQKVSVDKSFSR CCCCEEEECCCCCCC	31.47	22617229
714	Acetylation	FQKVSVDKSFSRGWS CEEEECCCCCCCCCC	51.77	18604479
714	Ubiquitination	FQKVSVDKSFSRGWS CEEEECCCCCCCCCC	51.77	-
715	Phosphorylation	QKVSVDKSFSRGWSR EEEECCCCCCCCCCC	24.80	28857561
717	Phosphorylation	VSVDKSFSRGWSRDQ EECCCCCCCCCCCCC	36.65	17081983
721	Phosphorylation	KSFSRGWSRDQPGQA CCCCCCCCCCCCCCC	28.89	22617229
734	Phosphorylation	QAPMRQRSATTTGSP CCCCCCCCCCCCCCC	22.94	28176443
736	Phosphorylation	PMRQRSATTTGSPGT CCCCCCCCCCCCCCH	26.57	28176443
737	Phosphorylation	MRQRSATTTGSPGTE CCCCCCCCCCCCCHH	28.95	20068231
738	Phosphorylation	RQRSATTTGSPGTEK CCCCCCCCCCCCHHH	31.16	29255136
740	Phosphorylation	RSATTTGSPGTEKAR CCCCCCCCCCHHHHH	20.33	29255136
743	Phosphorylation	TTTGSPGTEKARSIV CCCCCCCHHHHHHHH	37.38	29255136
748	Phosphorylation	PGTEKARSIVRQKTV CCHHHHHHHHHHCCC	30.23	-
754	Phosphorylation	RSIVRQKTVDIDDAQ HHHHHHCCCCCCCCC	18.31	29255136
761 (in isoform 3)	Phosphorylation	-	44.75	24076635
761 (in isoform 6)	Phosphorylation	-	44.75	24076635
767	Phosphorylation	AQILPRSTRVRHFSQ CCCCCCCCCEECCCC	34.17	24719451
773	Phosphorylation	STRVRHFSQSEETGN CCCEECCCCCHHHCC	27.03	29255136
775	Phosphorylation	RVRHFSQSEETGNEV CEECCCCCHHHCCHH	35.88	29255136
778	Phosphorylation	HFSQSEETGNEVFGA CCCCCHHHCCHHHCC	41.05	22167270
795	Phosphorylation	EEQPLPRSSSTSDIL CCCCCCCCCCCCCCC	27.05	29255136
795 (in isoform 3)	Phosphorylation	-	27.05	27732954
795 (in isoform 6)	Phosphorylation	-	27.05	27732954
796	Phosphorylation	EQPLPRSSSTSDILE CCCCCCCCCCCCCCC	38.63	29255136
797	Phosphorylation	QPLPRSSSTSDILEP CCCCCCCCCCCCCCC	32.93	29255136
798	Phosphorylation	PLPRSSSTSDILEPF CCCCCCCCCCCCCCC	32.16	29255136
798 (in isoform 3)	Phosphorylation	-	32.16	27732954
798 (in isoform 6)	Phosphorylation	-	32.16	27732954
799	Phosphorylation	LPRSSSTSDILEPFT CCCCCCCCCCCCCCC	25.30	25159151
802 (in isoform 3)	Phosphorylation	-	9.08	27732954
802 (in isoform 6)	Phosphorylation	-	9.08	27732954
806	Phosphorylation	SDILEPFTVERAKVN CCCCCCCCEEECCCC	31.97	23403867
813 (in isoform 3)	Phosphorylation	-	41.09	22210691
813 (in isoform 6)	Phosphorylation	-	41.09	22210691
814 (in isoform 3)	Phosphorylation	-	59.06	22210691
814 (in isoform 6)	Phosphorylation	-	59.06	22210691
826	Phosphorylation	QKLPPLNSDIGGSSA HCCCCCCCCCCCCCC	37.98	27732954
831	Phosphorylation	LNSDIGGSSANVPDL CCCCCCCCCCCCCHH	22.51	26657352
832	Phosphorylation	NSDIGGSSANVPDLM CCCCCCCCCCCCHHH	27.43	24173317
849	Phosphorylation	FIAERLRSGNASTMT HHHHHHHCCCCCCCC	40.78	26546556
853	Phosphorylation	RLRSGNASTMTRRGS HHHCCCCCCCCCCCC	23.78	26546556
854	Phosphorylation	LRSGNASTMTRRGSS HHCCCCCCCCCCCCC	21.83	26546556
860	Phosphorylation	STMTRRGSSPGSLEI CCCCCCCCCCCCCCC	31.39	19664994
861	Phosphorylation	TMTRRGSSPGSLEIP CCCCCCCCCCCCCCC	35.78	19664994
864	Phosphorylation	RRGSSPGSLEIPKDL CCCCCCCCCCCCCCH	26.64	29255136
958	Phosphorylation	AEEQEVASLTTLHID HHHHHHHHEEEEEEC	31.27	26074081
960	Phosphorylation	EQEVASLTTLHIDSE HHHHHHEEEEEECCC	25.47	26074081
966	Phosphorylation	LTTLHIDSETSSLNQ EEEEEECCCCCHHHH	42.02	22468782
986	Phosphorylation	EVATITGSESASPVH EEEEEECCCCCCCCC	21.52	24275569
988	Phosphorylation	ATITGSESASPVHSP EEEECCCCCCCCCCC	35.43	29460479
990	Phosphorylation	ITGSESASPVHSPLG EECCCCCCCCCCCCC	36.41	24275569
994	Phosphorylation	ESASPVHSPLGSRSQ CCCCCCCCCCCCCCC	23.27	29460479
1000	Phosphorylation	HSPLGSRSQTPSPST CCCCCCCCCCCCCCC	39.85	29255136
1002	Phosphorylation	PLGSRSQTPSPSTLN CCCCCCCCCCCCCCC	27.29	23401153
1004	Phosphorylation	GSRSQTPSPSTLNID CCCCCCCCCCCCCCC	34.57	29255136
1006	Phosphorylation	RSQTPSPSTLNIDHM CCCCCCCCCCCCCHH	50.27	29255136
1007	Phosphorylation	SQTPSPSTLNIDHME CCCCCCCCCCCCHHH	27.49	29255136
1133	Methylation	ILTPWLFKATMLTDK CCHHHHHHHHHCCHH	40.55	115976135
1324	Phosphorylation	ALNVICVSLKFTNKT HHHHHHEEECCCCHH	22.79	-
1368	Phosphorylation	IIQILIATITHLLPS HHHHHHHHHHHHCCC	21.29	-
1370	Phosphorylation	QILIATITHLLPSTE HHHHHHHHHHCCCCC	11.34	-
1420	Acetylation	ATGAESDKTEKSVLN HCCCCCCHHHHHHHH	68.79	19608861
1433	Acetylation	LNCIYKVLHGCVYGA HHHHHHHHHHHHHCH	2.22	19608861
1467	Acetylation	DYDPFMHLESLKEPE CCCCCCCHHHCCCCC	3.00	19608861
1478	O-linked_Glycosylation	KEPEPLHSPDSERSS CCCCCCCCCCCHHHC	37.78	29351928
1478	Phosphorylation	KEPEPLHSPDSERSS CCCCCCCCCCCHHHC	37.78	25849741
1481	Phosphorylation	EPLHSPDSERSSKLQ CCCCCCCCHHHCCCC	37.99	29255136
1554	Phosphorylation	LSPELFESPNIQFFV CCHHHHCCCCEEEEE	18.86	-
1565	Phosphorylation	QFFVLNNTTLVSCIQ EEEEECCCCEEEEEE	22.04	-
1569	Phosphorylation	LNNTTLVSCIQIRSE ECCCCEEEEEEEECC	14.49	-
1575	Phosphorylation	VSCIQIRSEENMPGG EEEEEEECCCCCCCC	51.39	-
1585	Phosphorylation	NMPGGGLSAGLASAN CCCCCCHHHHHHHCC	24.46	-
1590	Phosphorylation	GLSAGLASANSNVRI CHHHHHHHCCCCCEE	32.78	-
1593	Phosphorylation	AGLASANSNVRIIVR HHHHHCCCCCEEEEE	36.10	-
1614	Phosphorylation	SWDSAILYGPPPVSG CCCCEEEECCCCCCC	22.82	-
1658	Phosphorylation	ITVKDGLSLQFKRFR CCCCCCCEEEEHHHH	26.17	25159151
1673	Phosphorylation	ETVPTWDTIRDEEDV HCCCCCCCCCCHHHH	14.96	-
1776	Phosphorylation	LSILGMNSWDKRRSF HHHHCCCCCCHHHHH	27.97	-
1782	Phosphorylation	NSWDKRRSFHLLKKN CCCCHHHHHHHHHHH	22.50	24719451
1801	Phosphorylation	RELRNLDSRQCRETH HHHHCCCHHHHHHHH	27.67	-
1807	Phosphorylation	DSRQCRETHKIAVFY CHHHHHHHHCEEEEE	14.76	-
1910	Ubiquitination	NDEVHIVWSEHTRDY CCCEEEEEECCCCCC	9.44	-
1924	Phosphorylation	YRRGIIPTEFGDVLI CCCCCCCCCCCCEEE	33.27	28270605
1934	Phosphorylation	GDVLIVIYPMKNHMF CCEEEEEEECCCCEE	6.08	28270605
1942	Phosphorylation	PMKNHMFSIQIMKKP ECCCCEEEEEEECCC	13.15	22617229
1984	Ubiquitination	INASRALKSLIPLYQ HHHHHHHHHHHHHHH	42.08	-
1984 (in isoform 2)	Ubiquitination	-	42.08	-
1997	Ubiquitination	YQNFYEERARYLQTI HHHHHHHHHHHHHHH	16.66	-
2070 (in isoform 2)	Phosphorylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RGPA1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RGPA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RGPA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RGPA1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RGPA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797; SER-860 ANDSER-861, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-754; SER-773; SER-860;SER-861 AND SER-864, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-778 AND SER-797, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-773, AND MASSSPECTROMETRY.	17525332 [Abstract]