KIME_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIME_HUMAN
• UniProt AC: Q03426
• Protein Name: Mevalonate kinase {ECO:0000305}
• Gene Name: MVK {ECO:0000312|HGNC:HGNC:7530}
• Organism: Homo sapiens (Human).
• Sequence Length: 396
• Subcellular Localization: Cytoplasm . Peroxisome .
• Protein Description: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. [PubMed: 9325256]
• Protein Sequence: MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	GKVALAVSLNLRTFL CEEEEEEECCCHHHH	13.11	22210691
37	Phosphorylation	AVSLNLRTFLRLQPH EEECCCHHHHHCCCC	30.13	22210691
45	Phosphorylation	FLRLQPHSNGKVDLS HHHCCCCCCCCCCEE	54.70	-
59	Ubiquitination	SLPNIGIKRAWDVAR ECCCCCCCHHHHHHH	30.74	-
90	Ubiquitination	PTSEQVEKLKEVAGL CCHHHHHHHHHHCCC	67.03	-
92	Acetylation	SEQVEKLKEVAGLPD HHHHHHHHHHCCCCC	62.30	27452117
179	Ubiquitination	DCVNRWTKEDLELIN CCCCCCCHHHHHHHH	42.12	-
187	Ubiquitination	EDLELINKWAFQGER HHHHHHHHHHHCCCC	32.67	-
208	Phosphorylation	SGVDNAVSTWGGALR CCHHHHHHHCCHHHH	18.94	28857561
220	Ubiquitination	ALRYHQGKISSLKRS HHHHCCCCCHHCCCC	32.61	-
222	Phosphorylation	RYHQGKISSLKRSPA HHCCCCCHHCCCCCH	32.86	24719451
227	Phosphorylation	KISSLKRSPALQILL CCHHCCCCCHHHHHH	16.97	-
235	Phosphorylation	PALQILLTNTKVPRN CHHHHHHHCCCCCCC	37.08	28857561
237	Phosphorylation	LQILLTNTKVPRNTR HHHHHHCCCCCCCHH	28.34	28857561
238	Ubiquitination	QILLTNTKVPRNTRA HHHHHCCCCCCCHHH	52.92	-
256	Sumoylation	GVRNRLLKFPEIVAP HHHHHHHCCHHHHHH	64.56	-
330	Ubiquitination	RARGLHSKLTGAGGG HHCCCCCCCCCCCCC	39.04	-
345	Ubiquitination	GCGITLLKPGLEQPE CCCEEEECCCCCCCC	39.90	-
345	Sumoylation	GCGITLLKPGLEQPE CCCEEEECCCCCCCC	39.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIME_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIME_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIME_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIME_HUMAN	MVK	physical	16189514
METK1_HUMAN	MAT1A	physical	22939629
KIME_HUMAN	MVK	physical	25416956
CCD91_HUMAN	CCDC91	physical	26186194
CCD91_HUMAN	CCDC91	physical	28514442
TACC3_HUMAN	TACC3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.