METK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METK1_HUMAN
• UniProt AC: Q00266
• Protein Name: S-adenosylmethionine synthase isoform type-1
• Gene Name: MAT1A
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Protein Description: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate..
• Protein Sequence: MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	LLCGEITSMAMVDYQ EECCEEEEHHHHCHH	15.37	-
120	S-nitrosocysteine	QSPDIAQCVHLDRNE CCCCHHHHEECCCCC	1.22	-
120	S-nitrosylation	QSPDIAQCVHLDRNE CCCCHHHHEECCCCC	1.22	-
193	Ubiquitination	VQYMQDNGAVIPVRI EEEECCCCCEEEEEE	29.52	22817900
202	Phosphorylation	VIPVRIHTIVISVQH EEEEEEEEEEEEEEC	17.99	25850435
206	Phosphorylation	RIHTIVISVQHNEDI EEEEEEEEEECCCCC	12.58	25850435
223	Ubiquitination	EEMRRALKEQVIRAV HHHHHHHHHHHHHHH	45.15	-
234	Ubiquitination	IRAVVPAKYLDEDTV HHHHCCHHHCCCCCE	40.03	22817900
244	Ubiquitination	DEDTVYHLQPSGRFV CCCCEEEECCCCCEE	4.36	22817900
248	Ubiquitination	VYHLQPSGRFVIGGP EEEECCCCCEEECCC	33.46	22817900
264	Methylation	GDAGVTGRKIIVDTY CCCCCCCCEEEEECC	20.03	115367955
285	Ubiquitination	GGGAFSGKDYTKVDR CCCCCCCCCCCCCCH	46.49	22817900
289	Ubiquitination	FSGKDYTKVDRSAAY CCCCCCCCCCHHHHH	35.59	22817900
293	Phosphorylation	DYTKVDRSAAYAARW CCCCCCHHHHHHHHH	16.88	22167270
296	Phosphorylation	KVDRSAAYAARWVAK CCCHHHHHHHHHHHH	10.66	22167270
303	Ubiquitination	YAARWVAKSLVKAGL HHHHHHHHHHHHCCC	34.40	33845483
310	Ubiquitination	KSLVKAGLCRRVLVQ HHHHHCCCCHHHHHH	2.16	21890473
326	Ubiquitination	SYAIGVAEPLSISIF HHHHCCCCCCEEEEE	44.35	22817900
327	Ubiquitination	YAIGVAEPLSISIFT HHHCCCCCCEEEEEE	22.98	22817900
341	Phosphorylation	TYGTSQKTERELLDV ECCCCCCCHHHHHHH	32.41	-
351	Ubiquitination	ELLDVVHKNFDLRPG HHHHHHHHCCCCCCC	47.93	21890473
367	Ubiquitination	IVRDLDLKKPIYQKT EEEECCCCCCCCCCE	57.05	22817900
368	Ubiquitination	VRDLDLKKPIYQKTA EEECCCCCCCCCCEE	43.90	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METK1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
120	C	S-nitrosylation	S-nitrosylation of Cys-120 inactivates the enzyme.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
METK2_HUMAN	MAT2A	physical	22939629
METK1_HUMAN	MAT1A	physical	25416956
METK2_HUMAN	MAT2A	physical	26186194
MAT2B_HUMAN	MAT2B	physical	26186194
ASPC1_HUMAN	ASPSCR1	physical	26186194
DSCR3_HUMAN	DSCR3	physical	26344197
EF1A1_HUMAN	EEF1A1	physical	26344197
KIME_HUMAN	MVK	physical	26344197
MSS4_HUMAN	RABIF	physical	26344197
RPE_HUMAN	RPE	physical	26344197
METK2_HUMAN	MAT2A	physical	28514442
MAT2B_HUMAN	MAT2B	physical	28514442
ASPC1_HUMAN	ASPSCR1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 250850: Methionine adenosyltransferase deficiency (MATD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.