MAT2B_HUMAN - dbPTM
MAT2B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAT2B_HUMAN
UniProt AC Q9NZL9
Protein Name Methionine adenosyltransferase 2 subunit beta
Gene Name MAT2B
Organism Homo sapiens (Human).
Sequence Length 334
Subcellular Localization
Protein Description Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. [PubMed: 10644686]
Protein Sequence MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Acetylation--MVGREKELSIHFV
--CCCCCEEEEEEEC		63.7025953088
9PhosphorylationVGREKELSIHFVPGS
CCCCEEEEEEECCCC		18.3427080861
34PhosphorylationPNRRVLVTGATGLLG
CCCEEEEECHHHHHH		19.55-
37PhosphorylationRVLVTGATGLLGRAV
EEEEECHHHHHHHHH		29.70-
46AcetylationLLGRAVHKEFQQNNW
HHHHHHHHHHHHCCC		54.3391265
46UbiquitinationLLGRAVHKEFQQNNW
HHHHHHHHHHHHCCC		54.33-
110PhosphorylationENQPDAASQLNVDAS
CCCCCHHHHCCCCCC		36.6020068231
1682-HydroxyisobutyrylationKTKLDGEKAVLENNL
CCCCCCCHHHHHCCC		49.69-
168UbiquitinationKTKLDGEKAVLENNL
CCCCCCCHHHHHCCC		49.69-
186PhosphorylationVLRIPILYGEVEKLE
HHHHHEECCCHHHHH		16.3821406692
191UbiquitinationILYGEVEKLEESAVT
EECCCHHHHHHHCEE		67.39-
198 (in isoform 4)Ubiquitination-13.1321890473
198 (in isoform 2)Ubiquitination-13.1321890473
2032-HydroxyisobutyrylationAVTVMFDKVQFSNKS
CEEEEEEEEECCCCC		27.03-
209UbiquitinationDKVQFSNKSANMDHW
EEEECCCCCCCCHHH		50.1521890473
209MalonylationDKVQFSNKSANMDHW
EEEECCCCCCCCHHH		50.1526320211
209 (in isoform 3)Ubiquitination-50.1521890473
209AcetylationDKVQFSNKSANMDHW
EEEECCCCCCCCHHH		50.1525953088
209 (in isoform 1)Ubiquitination-50.1521890473
210PhosphorylationKVQFSNKSANMDHWQ
EEECCCCCCCCHHHH		29.1720873877
214 (in isoform 2)Ubiquitination-39.4121890473
214 (in isoform 4)Ubiquitination-39.4121890473
222PhosphorylationHWQQRFPTHVKDVAT
HHHHHCCHHHHHHHH		36.2720068231
225AcetylationQRFPTHVKDVATVCR
HHCCHHHHHHHHHHH		38.5926051181
225 (in isoform 1)Ubiquitination-38.5921890473
225 (in isoform 3)Ubiquitination-38.5921890473
225UbiquitinationQRFPTHVKDVATVCR
HHCCHHHHHHHHHHH		38.5921890473
2252-HydroxyisobutyrylationQRFPTHVKDVATVCR
HHCCHHHHHHHHHHH		38.59-
229PhosphorylationTHVKDVATVCRQLAE
HHHHHHHHHHHHHHH		21.7128258704
234 (in isoform 2)Ubiquitination-3.2521890473
234 (in isoform 4)Ubiquitination-3.2521890473
239SulfoxidationRQLAEKRMLDPSIKG
HHHHHHHCCCCCCCC		8.0321406390
243O-linked_GlycosylationEKRMLDPSIKGTFHW
HHHCCCCCCCCEEEE		36.2830379171
245 (in isoform 1)Ubiquitination-57.1221890473
245UbiquitinationRMLDPSIKGTFHWSG
HCCCCCCCCEEEECC		57.1221890473
259PhosphorylationGNEQMTKYEMACAIA
CCHHCCHHHHHHHHH		11.1927080861
271 (in isoform 2)Phosphorylation-3.34-
273PhosphorylationADAFNLPSSHLRPIT
HHHHCCCHHHCCCCC		33.2927794612
274PhosphorylationDAFNLPSSHLRPITD
HHHCCCHHHCCCCCC		25.3027794612
280PhosphorylationSSHLRPITDSPVLGA
HHHCCCCCCCCCCCC		32.8629255136
282PhosphorylationHLRPITDSPVLGAQR
HCCCCCCCCCCCCCC		14.3019664994
288 (in isoform 4)Ubiquitination-54.8621890473
298PhosphorylationRNAQLDCSKLETLGI
CCCCCCCHHCCCCCC		39.6820873877
298 (in isoform 4)Ubiquitination-39.6821890473
299UbiquitinationNAQLDCSKLETLGIG
CCCCCCHHCCCCCCC		57.59-
299AcetylationNAQLDCSKLETLGIG
CCCCCCHHCCCCCCC		57.5991269
305 (in isoform 2)Ubiquitination-4.8321890473
309PhosphorylationTLGIGQRTPFRIGIK
CCCCCCCCCEEEEEE		20.9225159151
315 (in isoform 2)Ubiquitination-4.1021890473
316UbiquitinationTPFRIGIKESLWPFL
CCEEEEEECHHHHHH		35.7221890473
316 (in isoform 1)Ubiquitination-35.7221890473
318PhosphorylationFRIGIKESLWPFLID
EEEEEECHHHHHHHC		30.6326074081
326 (in isoform 1)Ubiquitination-47.0321890473
326UbiquitinationLWPFLIDKRWRQTVF
HHHHHHCHHHHHCCC		47.0321890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAT2B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAT2B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAT2B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
TENS3_HUMANTNS3physical
22939629
IF4H_HUMANEIF4Hphysical
22863883
AGAL_HUMANGLAphysical
22863883
NASP_HUMANNASPphysical
22863883
PDIA6_HUMANPDIA6physical
22863883
UGDH_HUMANUGDHphysical
22863883
METK2_HUMANMAT2Aphysical
26186194
GALE_HUMANGALEphysical
26344197
GMDS_HUMANGMDSphysical
26344197
METK2_HUMANMAT2Aphysical
26344197
SPS1_HUMANSEPHS1physical
26344197
FCL_HUMANTSTA3physical
26344197
XPO1_HUMANXPO1physical
26344197
METK2_HUMANMAT2Aphysical
21516116
METK2_HUMANMAT2Aphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00134L-Methionine
Regulatory Network of MAT2B_HUMAN

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Related Literatures of Post-Translational Modification

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