GALE_HUMAN - dbPTM
GALE_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GALE_HUMAN
UniProt AC Q14376
Protein Name UDP-glucose 4-epimerase {ECO:0000303|PubMed:22654673}
Gene Name GALE {ECO:0000312|HGNC:HGNC:4116}
Organism Homo sapiens (Human).
Sequence Length 348
Subcellular Localization
Protein Description Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids..
Protein Sequence MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26UbiquitinationVLELLEAGYLPVVID
HHHHHHCCCCCEEEE		18.3521890473
44PhosphorylationNAFRGGGSLPESLRR
HHHCCCCCCCHHHHH		43.9824719451
65SulfoxidationRSVEFEEMDILDQGA
CCCCHHHHCCCCHHH		2.8230846556
80PhosphorylationLQRLFKKYSFMAVIH
HHHHHHHHCHHHHHH		14.0224719451
81PhosphorylationQRLFKKYSFMAVIHF
HHHHHHHCHHHHHHH		19.8824719451
97PhosphorylationGLKAVGESVQKPLDY
CHHHHHHHCCCCCCE		24.7424719451
100UbiquitinationAVGESVQKPLDYYRV
HHHHHCCCCCCEEEE		45.4521890473
100UbiquitinationAVGESVQKPLDYYRV
HHHHHCCCCCCEEEE		45.4521890473
100AcetylationAVGESVQKPLDYYRV
HHHHHCCCCCCEEEE		45.4523236377
104PhosphorylationSVQKPLDYYRVNLTG
HCCCCCCEEEECCCC		10.8020068231
120UbiquitinationIQLLEIMKAHGVKNL
HHHHHHHHHCCCCEE		42.7821890473
157PhosphorylationTGGCTNPYGKSKFFI
CCCCCCCCCCCHHHH		38.9820090780
159UbiquitinationGCTNPYGKSKFFIEE
CCCCCCCCCHHHHHH		44.63-
161UbiquitinationTNPYGKSKFFIEEMI
CCCCCCCHHHHHHHH		48.0221906983
176AcetylationRDLCQADKTWNAVLL
HHHHHCCCCCCEEEH		59.4625953088
176UbiquitinationRDLCQADKTWNAVLL
HHHHHCCCCCCEEEH		59.46-
230PhosphorylationLNVFGNDYDTEDGTG
HHHHCCCCCCCCCCC		28.8527642862
232PhosphorylationVFGNDYDTEDGTGVR
HHCCCCCCCCCCCCC		29.73-
249UbiquitinationIHVVDLAKGHIAALR
EEEEHHHHHHHHHHH		59.3221890473
249UbiquitinationIHVVDLAKGHIAALR
EEEEHHHHHHHHHHH		59.3221906983
259UbiquitinationIAALRKLKEQCGCRI
HHHHHHHHHHHCCEE		49.09-
2592-HydroxyisobutyrylationIAALRKLKEQCGCRI
HHHHHHHHHHHCCEE		49.09-
267PhosphorylationEQCGCRIYNLGTGTG
HHHCCEEEECCCCCC		5.7420068231
271PhosphorylationCRIYNLGTGTGYSVL
CEEEECCCCCCHHHH		34.4320068231
273PhosphorylationIYNLGTGTGYSVLQM
EEECCCCCCHHHHHH		32.5520068231
275PhosphorylationNLGTGTGYSVLQMVQ
ECCCCCCHHHHHHHH		8.7420068231
276PhosphorylationLGTGTGYSVLQMVQA
CCCCCCHHHHHHHHH		20.0720068231
286UbiquitinationQMVQAMEKASGKKIP
HHHHHHHHHCCCCCC		34.4621890473
295UbiquitinationSGKKIPYKVVARREG
CCCCCCCEEEECCCC		25.52-
338UbiquitinationEDLWRWQKQNPSGFG
HHHHHHHHHCCCCCC		45.122190698
338UbiquitinationEDLWRWQKQNPSGFG
HHHHHHHHHCCCCCC		45.1221890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GALE_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GALE_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GALE_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GALE_HUMANGALEphysical
16189514
A4_HUMANAPPphysical
21832049
GALE_HUMANGALEphysical
25416956
GALE_HUMANGALEphysical
18188677
ACADM_HUMANACADMphysical
26344197
MTND_HUMANADI1physical
26344197
ARMC1_HUMANARMC1physical
26344197
ASNS_HUMANASNSphysical
26344197
CD2AP_HUMANCD2APphysical
26344197
ETFA_HUMANETFAphysical
26344197
GALK2_HUMANGALK2physical
26344197
ITPA_HUMANITPAphysical
26344197
PAXI_HUMANPXNphysical
26344197
WDR1_HUMANWDR1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
230350Epimerase-deficiency galactosemia (EDG)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GALE_HUMAN

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Related Literatures of Post-Translational Modification

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