dbPTM

ARMC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARMC1_HUMAN
UniProt AC	Q9NVT9
Protein Name	Armadillo repeat-containing protein 1
Gene Name	ARMC1
Organism	Homo sapiens (Human).
Sequence Length	282
Subcellular Localization
Protein Description
Protein Sequence	MNSSTSTMSEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGLILFMDHPNPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKTTTPGETKLLASEIYDILQSSNMADGDSFNEMNSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGEEMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFLSRSFYW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNSSTSTM -------CCCCCCCC	11.22	22814378
2 (in isoform 2)	Phosphorylation	-	44.67	26552605
3	Phosphorylation	-----MNSSTSTMSE -----CCCCCCCCCC	33.42	28464451
4	Phosphorylation	----MNSSTSTMSEE ----CCCCCCCCCCC	22.75	28348404
5	Phosphorylation	---MNSSTSTMSEEP ---CCCCCCCCCCCC	28.21	28464451
6	Phosphorylation	--MNSSTSTMSEEPD --CCCCCCCCCCCCC	24.86	28464451
6 (in isoform 2)	Phosphorylation	-	24.86	26552605
7	Phosphorylation	-MNSSTSTMSEEPDA -CCCCCCCCCCCCCH	25.46	28464451
9 (in isoform 2)	Phosphorylation	-	38.61	26552605
9	Phosphorylation	NSSTSTMSEEPDALS CCCCCCCCCCCCHHH	38.61	28464451
12 (in isoform 2)	Phosphorylation	-	28.29	26552605
15 (in isoform 2)	Phosphorylation	-	5.35	26552605
16 (in isoform 2)	Phosphorylation	-	26.24	26552605
90	Ubiquitination	MLSLQNVIQKTTTPG HHHHHHHHHHCCCCC	4.57	-
90	Ubiquitination	MLSLQNVIQKTTTPG HHHHHHHHHHCCCCC	4.57	21963094
93	Phosphorylation	LQNVIQKTTTPGETK HHHHHHHCCCCCHHH	21.37	-
95	Phosphorylation	NVIQKTTTPGETKLL HHHHHCCCCCHHHHH	34.23	-
102	Ubiquitination	TPGETKLLASEIYDI CCCHHHHHHHHHHHH	5.41	33845483
105	Ubiquitination	ETKLLASEIYDILQS HHHHHHHHHHHHHHC	39.70	29967540
120	Phosphorylation	SNMADGDSFNEMNSR CCCCCCCCHHHHHHH	35.19	25159151
126	Phosphorylation	DSFNEMNSRRRKAQF CCHHHHHHHHHHHHE	26.34	26434776
130	Ubiquitination	EMNSRRRKAQFFLGT HHHHHHHHHHEEEEC	44.74	29967540
137	Phosphorylation	KAQFFLGTTNKRAKT HHHEEEECCCCCCCE	29.37	28152594
138	Phosphorylation	AQFFLGTTNKRAKTV HHEEEECCCCCCCEE	36.62	28152594
140	Ubiquitination	FFLGTTNKRAKTVVL EEEECCCCCCCEEEE	52.20	32142685
140	Acetylation	FFLGTTNKRAKTVVL EEEECCCCCCCEEEE	52.20	25953088
144	Phosphorylation	TTNKRAKTVVLHIDG CCCCCCCEEEEEECC	18.18	29214152
155	Phosphorylation	HIDGLDDTSRRNLCE EECCCCCHHHCCHHH	24.65	29083192
156	Phosphorylation	IDGLDDTSRRNLCEE ECCCCCHHHCCHHHH	35.92	29083192
167	Ubiquitination	LCEEALLKIKGVISF HHHHHHHHHHCCHHH	43.13	29967540
173	Phosphorylation	LKIKGVISFTFQMAV HHHHCCHHHHHHHHH	18.81	26074081
175	Phosphorylation	IKGVISFTFQMAVQR HHCCHHHHHHHHHHH	13.23	26074081
189	Phosphorylation	RCVVRIRSDLKAEAL HHHHHHCCHHHHHHH	44.94	28464451
192	Ubiquitination	VRIRSDLKAEALASA HHHCCHHHHHHHHHH	49.52	21963094
202	Phosphorylation	ALASAIASTKVMKAQ HHHHHHHHHHHHHHH	23.73	23612710
203	Phosphorylation	LASAIASTKVMKAQQ HHHHHHHHHHHHHHH	20.73	23612710
204	Ubiquitination	ASAIASTKVMKAQQV HHHHHHHHHHHHHHE	37.52	33845483
207	Ubiquitination	IASTKVMKAQQVVKS HHHHHHHHHHHEEEC	46.13	29967540
214	Phosphorylation	KAQQVVKSESGEEML HHHHEEECCCCCCEE	25.94	20068231
216	Phosphorylation	QQVVKSESGEEMLVP HHEEECCCCCCEEEE	59.60	20068231
227	Phosphorylation	MLVPFQDTPVEVEQN EEEECCCCCEEEECC	20.60	20068231
235	Phosphorylation	PVEVEQNTELPDYLP CEEEECCCCCCCCCC	38.30	20068231
240	Phosphorylation	QNTELPDYLPEDESP CCCCCCCCCCCCCCC	23.40	23663014
246	Phosphorylation	DYLPEDESPTKEQDK CCCCCCCCCCHHHHH	50.63	25159151
248	Phosphorylation	LPEDESPTKEQDKAV CCCCCCCCHHHHHHH	57.39	28176443
256	Phosphorylation	KEQDKAVSRVGSHPE HHHHHHHHHCCCCCC	26.55	22210691
260	Phosphorylation	KAVSRVGSHPEGGAS HHHHHCCCCCCCCHH	32.77	28176443
267	Phosphorylation	SHPEGGASWLSTAAN CCCCCCHHHHHHHHH	31.65	28176443
270	Phosphorylation	EGGASWLSTAANFLS CCCHHHHHHHHHHHH	15.11	28450419
271	Phosphorylation	GGASWLSTAANFLSR CCHHHHHHHHHHHHH	27.85	28450419
277	Phosphorylation	STAANFLSRSFYW-- HHHHHHHHHHCCC--	23.03	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARMC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARMC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARMC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
EPS8_HUMAN	EPS8	physical	21988832
MFR1L_HUMAN	MTFR1L	physical	25416956
DPYL1_HUMAN	CRMP1	physical	26186194
DPYL3_HUMAN	DPYSL3	physical	26186194
DPYL2_HUMAN	DPYSL2	physical	26186194
STXB1_HUMAN	STXBP1	physical	26186194
ATP4A_HUMAN	ATP4A	physical	26186194
DPYL5_HUMAN	DPYSL5	physical	26186194
KCC2A_HUMAN	CAMK2A	physical	26186194
KCC2B_HUMAN	CAMK2B	physical	26186194
DJC11_HUMAN	DNAJC11	physical	26186194
GPM6B_HUMAN	GPM6B	physical	26186194
H2B1L_HUMAN	HIST1H2BL	physical	26186194
VISL1_HUMAN	VSNL1	physical	26186194
NCAM1_HUMAN	NCAM1	physical	26186194
E41L1_HUMAN	EPB41L1	physical	26186194
GNAO_HUMAN	GNAO1	physical	26186194
GBG2_HUMAN	GNG2	physical	26186194
GPM6A_HUMAN	GPM6A	physical	26186194
SYUB_HUMAN	SNCB	physical	26186194
SYN2_HUMAN	SYN2	physical	26186194
SYN1_HUMAN	SYN1	physical	26186194
RAB3A_HUMAN	RAB3A	physical	26186194
CNTN1_HUMAN	CNTN1	physical	26186194
MTAP2_HUMAN	MAP2	physical	26186194
CAMKV_HUMAN	CAMKV	physical	26186194
NCALD_HUMAN	NCALD	physical	26186194
STX1B_HUMAN	STX1B	physical	26186194
SYT1_HUMAN	SYT1	physical	26186194
DAAF5_HUMAN	DNAAF5	physical	26344197
GARS_HUMAN	GARS	physical	26344197
HNRDL_HUMAN	HNRNPDL	physical	26344197
HPBP1_HUMAN	HSPBP1	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
H2B1L_HUMAN	HIST1H2BL	physical	28514442
VISL1_HUMAN	VSNL1	physical	28514442
ATP4A_HUMAN	ATP4A	physical	28514442
STX1B_HUMAN	STX1B	physical	28514442
SYN1_HUMAN	SYN1	physical	28514442
DPYL3_HUMAN	DPYSL3	physical	28514442
DPYL1_HUMAN	CRMP1	physical	28514442
MTAP2_HUMAN	MAP2	physical	28514442
KCC2A_HUMAN	CAMK2A	physical	28514442
STXB1_HUMAN	STXBP1	physical	28514442
GPM6A_HUMAN	GPM6A	physical	28514442
DJC11_HUMAN	DNAJC11	physical	28514442
SYUB_HUMAN	SNCB	physical	28514442
RAB3A_HUMAN	RAB3A	physical	28514442
SYN2_HUMAN	SYN2	physical	28514442
TAU_HUMAN	MAPT	physical	28514442
E41L1_HUMAN	EPB41L1	physical	28514442
GBG2_HUMAN	GNG2	physical	28514442
SYT1_HUMAN	SYT1	physical	28514442
GNAO_HUMAN	GNAO1	physical	28514442
NCAM1_HUMAN	NCAM1	physical	28514442
CNTN1_HUMAN	CNTN1	physical	28514442
DPYL2_HUMAN	DPYSL2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARMC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260, AND MASSSPECTROMETRY.	19690332 [Abstract]