dbPTM

SYN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYN2_HUMAN
UniProt AC	Q92777
Protein Name	Synapsin-2
Gene Name	SYN2
Organism	Homo sapiens (Human).
Sequence Length	582
Subcellular Localization	Cell junction, synapse.
Protein Description	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity)..
Protein Sequence	MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPPGPGAASASAAPPTASPGPERRPPPASAPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVDEPHADWAKCFRGKKVLGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLGGEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDSKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKDPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPPGPSLPPSSSSSSSSSSSAPQRPGGPTTHGDAPSSSSSLAEAQPPLAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	NFLRRRLSDSSFIAN CHHHHHCCCCCHHHC	33.37	29978859
12	Phosphorylation	LRRRLSDSSFIANLP HHHHCCCCCHHHCCC	24.63	27732954
13	Phosphorylation	RRRLSDSSFIANLPN HHHCCCCCHHHCCCC	26.18	27732954
22	Phosphorylation	IANLPNGYMTDLQRP HHCCCCCCCCCCCCC	11.95	29978859
24	Phosphorylation	NLPNGYMTDLQRPEP CCCCCCCCCCCCCCC	25.69	29978859
66	Phosphorylation	ERRPPPASAPAPQPA CCCCCCCCCCCCCCC	36.57	24076635
66	Phosphorylation	ERRPPPASAPAPQPA CCCCCCCCCCCCCCC	36.57	24076635
93	Phosphorylation	LSQAVKQTAASAGLV HHHHHHHHHHHCCCC	20.62	22210691
96	Phosphorylation	AVKQTAASAGLVDAP HHHHHHHHCCCCCCC	22.02	22210691
332	Phosphorylation	AYMRTSISGNWKTNT EEEEEECCCCCCCCC	26.33	25307156
337	Phosphorylation	SISGNWKTNTGSAML ECCCCCCCCCCHHHH	29.63	24076635
339	Phosphorylation	SGNWKTNTGSAMLEQ CCCCCCCCCHHHHHH	37.43	24076635
341	Phosphorylation	NWKTNTGSAMLEQIA CCCCCCCHHHHHHHH	14.41	24076635
412	Phosphorylation	LITELVISKMNQLLS HHHHHHHHHHHHHHH	20.55	24076635
419	Phosphorylation	SKMNQLLSRTPALSP HHHHHHHHCCCCCCC	42.58	25332170
421	Phosphorylation	MNQLLSRTPALSPQR HHHHHHCCCCCCCCC	14.99	18510355
425	Phosphorylation	LSRTPALSPQRPLTT HHCCCCCCCCCCCCC	22.54	21082442
431	Phosphorylation	LSPQRPLTTQQPQSG CCCCCCCCCCCCCCC	25.82	29978859
432	Phosphorylation	SPQRPLTTQQPQSGT CCCCCCCCCCCCCCC	32.65	18510355
437	Phosphorylation	LTTQQPQSGTLKDPD CCCCCCCCCCCCCCC	40.19	29978859
439	Phosphorylation	TQQPQSGTLKDPDSS CCCCCCCCCCCCCCC	35.56	29978859
441	Ubiquitination	QPQSGTLKDPDSSKT CCCCCCCCCCCCCCC	68.03	2190698
441 (in isoform 2)	Ubiquitination	-	68.03	21906983
441 (in isoform 1)	Ubiquitination	-	68.03	21906983
448	Phosphorylation	KDPDSSKTPPQRPPP CCCCCCCCCCCCCCC	41.99	27732954
488	Phosphorylation	PSLPPSSSSSSSSSS CCCCCCCCCCCCCCC	38.28	-
489	Phosphorylation	SLPPSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
490	Phosphorylation	LPPSSSSSSSSSSSA CCCCCCCCCCCCCCC	35.87	-
491	Phosphorylation	PPSSSSSSSSSSSAP CCCCCCCCCCCCCCC	35.87	-
540	Phosphorylation	PHPQLNKSQSLTNAF CCCCCCCCCHHHHHH	24.75	27732954
542	Phosphorylation	PQLNKSQSLTNAFSF CCCCCCCHHHHHHCC	44.23	24719451
544	Phosphorylation	LNKSQSLTNAFSFSE CCCCCHHHHHHCCCH	29.73	27732954
553	Phosphorylation	AFSFSESSFFRSSAN HHCCCHHHHHCCCCC	25.09	24719451
571	Phosphorylation	AKAETIRSLRKSFAS HHHHHHHHHHHHHHH	28.77	24719451
575	Phosphorylation	TIRSLRKSFASLFSD HHHHHHHHHHHHHCC	21.44	29691806
578	Phosphorylation	SLRKSFASLFSD--- HHHHHHHHHHCC---	28.12	29691806

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	S	Phosphorylation	Kinase	CAMK1	Q14012	Uniprot
10	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
10	S	Phosphorylation	Kinase	PKA	-	Uniprot
10	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
10	S	Phosphorylation	-
Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles.
425	S	Phosphorylation	-
Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYN2_HUMAN	SYN2	physical	10358015
SYN1_HUMAN	SYN1	physical	10358015
1433Z_HUMAN	YWHAZ	physical	10358015
1433E_HUMAN	YWHAE	physical	10358015
SYN3_HUMAN	SYN3	physical	10358015
PRS6A_HUMAN	PSMC3	physical	11032911

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYN2_HUMAN

Related Literatures of Post-Translational Modification

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