SYN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYN3_HUMAN
• UniProt AC: O14994
• Protein Name: Synapsin-3
• Gene Name: SYN3
• Organism: Homo sapiens (Human).
• Sequence Length: 580
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
• Protein Description: May be involved in the regulation of neurotransmitter release and synaptogenesis..
• Protein Sequence: MNFLRRRLSDSSFMANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSLSSAMKQAPQATSGLMEPPGPSTPIVQRPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQPQPRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQQGEESKKPAPPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAETIRNLRKSFASLFSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	NFLRRRLSDSSFMAN CCCHHHCCCCCHHHC	33.37	-
12	Phosphorylation	RRRLSDSSFMANLPN HHHCCCCCHHHCCCC	24.83	22210691
32	Phosphorylation	LQRPDSSTSSPASPA CCCCCCCCCCCCCHH	36.86	22210691
51	Phosphorylation	HPQPLAASFSSPGSS CCCCCHHHCCCCCHH	21.76	24247654
53	Phosphorylation	QPLAASFSSPGSSLF CCCHHHCCCCCHHHH	32.88	24719451
54	Phosphorylation	PLAASFSSPGSSLFS CCHHHCCCCCHHHHH	31.13	25307156
362	Phosphorylation	HSKDGRDYIIEVMDS ECCCCCEEEEEEECC	11.48	29759185
370	Phosphorylation	IIEVMDSSMPLIGEH EEEEECCCCCCCCCC	21.83	29759185
416	Phosphorylation	PWAPQIKSAKSPGQA CCCCCCCCCCCCCCC	42.43	24719451
453	Phosphorylation	QSPQPQRSGSPSQQR CCCCCCCCCCCCCCC	38.07	25332170
455	Phosphorylation	PQPQRSGSPSQQRLS CCCCCCCCCCCCCCC	23.71	25307156
457	Phosphorylation	PQRSGSPSQQRLSPQ CCCCCCCCCCCCCCC	40.41	25307156
462	Phosphorylation	SPSQQRLSPQGQQPL CCCCCCCCCCCCCCC	19.84	22817900
470	Phosphorylation	PQGQQPLSPQSGSPQ CCCCCCCCCCCCCCC	27.81	15900227
473	Phosphorylation	QQPLSPQSGSPQQQR CCCCCCCCCCCCHHC	44.62	29255136
475	Phosphorylation	PLSPQSGSPQQQRSP CCCCCCCCCCHHCCC	25.45	29255136
481	Phosphorylation	GSPQQQRSPGSPQLS CCCCHHCCCCCCCHH	29.31	23927012
484	Phosphorylation	QQQRSPGSPQLSRAS CHHCCCCCCCHHHCC	16.92	25849741
488	Phosphorylation	SPGSPQLSRASSGSS CCCCCCHHHCCCCCC	22.13	30177828
491	Phosphorylation	SPQLSRASSGSSPNQ CCCHHHCCCCCCCCC	33.84	25332170
492	Phosphorylation	PQLSRASSGSSPNQA CCHHHCCCCCCCCCC	41.53	24719451
494	Phosphorylation	LSRASSGSSPNQASK HHHCCCCCCCCCCCC	44.57	23312004
495	Phosphorylation	SRASSGSSPNQASKP HHCCCCCCCCCCCCC	31.25	25332170
500	Phosphorylation	GSSPNQASKPGATLA CCCCCCCCCCCCCCC	29.62	23312004
505	Phosphorylation	QASKPGATLASQPRP CCCCCCCCCCCCCCC	28.86	25332170
508	Phosphorylation	KPGATLASQPRPPVQ CCCCCCCCCCCCCCC	43.78	23312004
518	Phosphorylation	RPPVQGRSTSQQGEE CCCCCCCCCCCCCCC	38.95	20873877
519	Phosphorylation	PPVQGRSTSQQGEES CCCCCCCCCCCCCCC	29.24	20873877
520	Phosphorylation	PVQGRSTSQQGEESK CCCCCCCCCCCCCCC	23.04	20873877
526	Phosphorylation	TSQQGEESKKPAPPH CCCCCCCCCCCCCCC	41.50	20873877
539	Phosphorylation	PHPHLNKSQSLTNSL CCCCCCCCHHHHHHC	24.75	29978859
541	Phosphorylation	PHLNKSQSLTNSLST CCCCCCHHHHHHCCC	44.23	29116813
543	Phosphorylation	LNKSQSLTNSLSTSD CCCCHHHHHHCCCCC	28.19	23312004
545	Phosphorylation	KSQSLTNSLSTSDTS CCHHHHHHCCCCCCC	20.61	23312004
547	Phosphorylation	QSLTNSLSTSDTSQR HHHHHHCCCCCCCCC	26.20	23312004
548	Phosphorylation	SLTNSLSTSDTSQRG HHHHHCCCCCCCCCC	35.60	23312004
549	Phosphorylation	LTNSLSTSDTSQRGT HHHHCCCCCCCCCCC	35.20	23312004
551	Phosphorylation	NSLSTSDTSQRGTPS HHCCCCCCCCCCCCC	26.90	23312004
552	Phosphorylation	SLSTSDTSQRGTPSE HCCCCCCCCCCCCCH	23.91	23312004
572	Acetylation	ETIRNLRKSFASLFS HHHHHHHHHHHHHHC	53.76	155687
573	Phosphorylation	TIRNLRKSFASLFSD HHHHHHHHHHHHHCC	21.44	29691806
576	Phosphorylation	NLRKSFASLFSD--- HHHHHHHHHHCC---	28.12	29691806

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
9	S	Phosphorylation	Kinase	CAMK1	Q14012	Uniprot
9	S	Phosphorylation	Kinase	PKA	-	Uniprot
470	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
470	S	Phosphorylation	Kinase	CDK1	P11440	PSP
470	S	Phosphorylation	Kinase	MK03	P27361	PhosphoELM
470	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS
470	S	Phosphorylation	Kinase	MAPK	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
9	S	Phosphorylation	Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYN3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SYN3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.