GALK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALK2_HUMAN
• UniProt AC: Q01415
• Protein Name: N-acetylgalactosamine kinase
• Gene Name: GALK2
• Organism: Homo sapiens (Human).
• Sequence Length: 458
• Protein Description: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates..
• Protein Sequence: MATESPATRRVQVAEHPRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGLKGIQEHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKYKSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEICRCLGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPEKQSLFATKPGGGALVLLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATESPATRR -----CCCCCCCCCC	35.38	29255136
5	Phosphorylation	---MATESPATRRVQ ---CCCCCCCCCCCC	18.58	29255136
24	Ubiquitination	PRLLKLKEMFNSKFG HHHHHHHHHHHHCCC	60.49	21890473
32	Phosphorylation	MFNSKFGSIPKFYVR HHHHCCCCCCEEEEE	38.56	23403867
35	Ubiquitination	SKFGSIPKFYVRAPG HCCCCCCEEEEECCC	47.89	21890473
102	Ubiquitination	ANNIQIDKTKPLWHN CCCCCCCCCCCCCCH	61.14	-
104	Ubiquitination	NIQIDKTKPLWHNYF CCCCCCCCCCCCHHH	43.80	-
168	Ubiquitination	VLGRNLSKVELAEIC HCCCCCCHHHHHHHH	42.78	21890473
177	Ubiquitination	ELAEICAKSERYIGT HHHHHHHHCCCEECC	48.73	-
203	Ubiquitination	LAEEGTAKLIEFSPL HHHCCCEEEEEECCC	50.24	-
208	Phosphorylation	TAKLIEFSPLRATDV CEEEEEECCCCCCCC	15.38	27050516
234	Acetylation	NSCVEMNKAATSHFN CCHHHHCHHHHCCCC	37.78	24431215
252	Ubiquitination	MECRLAAKLLAKYKS HHHHHHHHHHHHHHC	38.13	-
256	Ubiquitination	LAAKLLAKYKSLQWD HHHHHHHHHHCCCHH	53.86	-
258	Ubiquitination	AKLLAKYKSLQWDKV HHHHHHHHCCCHHHC	43.94	-
264	Ubiquitination	YKSLQWDKVLRLEEV HHCCCHHHCCCHHHH	39.96	-
320	Phosphorylation	TQILSPNTQDVLIFK HHHCCCCCHHHHHHH	29.54	23879269
327	Ubiquitination	TQDVLIFKLYQRAKH CHHHHHHHHHHHHHH	39.01	-
333	Ubiquitination	FKLYQRAKHVYSEAA HHHHHHHHHHHHHHH	35.47	-
336	Phosphorylation	YQRAKHVYSEAARVL HHHHHHHHHHHHHHH	10.66	-
347	Ubiquitination	ARVLQFKKICEEAPE HHHHHHHHHHHHCCH	54.61	-
375	Phosphorylation	HMSCRDMYECSCPEL CCCHHHHHHCCCHHH	20.34	-
391	Ubiquitination	QLVDICRKFGAQGSR HHHHHHHHHCCCCCC	43.68	-
416	Ubiquitination	VSMVPADKLPSFLAN EEEEEHHHCHHHHHH	65.49	-
419	Phosphorylation	VPADKLPSFLANVHK EEHHHCHHHHHHHHH	43.24	-
440	Ubiquitination	DGSLAPEKQSLFATK CCCCCCCHHCCEEEC	44.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LKHA4_HUMAN	LTA4H	physical	26344197
MEMO1_HUMAN	MEMO1	physical	26344197
MVD1_HUMAN	MVD	physical	26344197
POTEF_HUMAN	POTEF	physical	28514442
CCD18_HUMAN	CCDC18	physical	28514442
PABP3_HUMAN	PABPC3	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
CD59_HUMAN	CD59	physical	28514442
AHNK_HUMAN	AHNAK	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.