HMGN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMGN4_HUMAN
• UniProt AC: O00479
• Protein Name: High mobility group nucleosome-binding domain-containing protein 4
• Gene Name: HMGN4
• Organism: Homo sapiens (Human).
• Sequence Length: 90
• Subcellular Localization: Nucleus.
• Protein Sequence: MPKRKAKGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPRPKKASAKKGEKLPKGRKGKADAGKDGNNPAKNRDASTLQSQKAEGTGDAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MPKRKAKGDAKGDK -CCCCCCCCCCCCCH	61.43	7354851
14	Acetylation	KGDAKGDKAKVKDEP CCCCCCCHHHCCCCH	59.79	7354859
18	Succinylation	KGDKAKVKDEPQRRS CCCHHHCCCCHHHHH	56.52	23954790
25	Phosphorylation	KDEPQRRSARLSAKP CCCHHHHHHHHCCCC	21.67	29496963
29	Phosphorylation	QRRSARLSAKPAPPK HHHHHHHCCCCCCCC	28.79	25159151
29	ADP-ribosylation	QRRSARLSAKPAPPK HHHHHHHCCCCCCCC	28.79	28190768
31	Acetylation	RSARLSAKPAPPKPE HHHHHCCCCCCCCCC	38.03	23954790
31	Succinylation	RSARLSAKPAPPKPE HHHHHCCCCCCCCCC	38.03	23954790
31	Ubiquitination	RSARLSAKPAPPKPE HHHHHCCCCCCCCCC	38.03	-
36	Acetylation	SAKPAPPKPEPRPKK CCCCCCCCCCCCCCC	62.04	26051181
51	Acetylation	ASAKKGEKLPKGRKG CCCCCCCCCCCCCCC	77.94	25953088
64	Acetylation	KGKADAGKDGNNPAK CCCCCCCCCCCCHHH	65.27	26051181
71	Ubiquitination	KDGNNPAKNRDASTL CCCCCHHHCCCHHHH	54.49	-
71	Acetylation	KDGNNPAKNRDASTL CCCCCHHHCCCHHHH	54.49	22361335
76	Phosphorylation	PAKNRDASTLQSQKA HHHCCCHHHHHHHHH	33.66	21712546
77	Phosphorylation	AKNRDASTLQSQKAE HHCCCHHHHHHHHHC	30.45	23663014
80	Phosphorylation	RDASTLQSQKAEGTG CCHHHHHHHHHCCCC	36.44	23401153
82	Acetylation	ASTLQSQKAEGTGDA HHHHHHHHHCCCCCC	54.36	19608861
86	Phosphorylation	QSQKAEGTGDAK--- HHHHHCCCCCCC---	24.32	23403867
90	Acetylation	AEGTGDAK------- HCCCCCCC-------	66.66	61175

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMGN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMGN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMGN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HMGN4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.
PubMed: 18669648