| UniProt ID | ST1C2_HUMAN | |
|---|---|---|
| UniProt AC | O00338 | |
| Protein Name | Sulfotransferase 1C2 | |
| Gene Name | SULT1C2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 296 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).. | |
| Protein Sequence | MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | O-linked_Glycosylation | ----MALTSDLGKQI ----CCCCCCHHCCE | 15.62 | 30379171 | |
| 117 (in isoform 2) | Phosphorylation | - | 41.97 | - | |
| 139 | Phosphorylation | NAKDCMVSYYHFQRM CHHHHHEEHHHHHHH | 7.96 | 28857561 | |
| 219 | Phosphorylation | MGKKVDETVLDKIVQ HCCCCCHHHHHHHHH | 23.16 | 21712546 | |
| 242 | Phosphorylation | ENPMTNRSTVSKSIL HCCCCCCHHHCHHHH | 34.92 | 28857561 | |
| 243 | Phosphorylation | NPMTNRSTVSKSILD CCCCCCHHHCHHHHH | 26.09 | 28857561 | |
| 245 | Phosphorylation | MTNRSTVSKSILDQS CCCCHHHCHHHHHHH | 22.30 | 28857561 | |
| 247 | Phosphorylation | NRSTVSKSILDQSIS CCHHHCHHHHHHHHH | 22.37 | 26657352 | |
| 252 | Phosphorylation | SKSILDQSISSFMRK CHHHHHHHHHHHHHC | 24.89 | 26657352 | |
| 254 | Phosphorylation | SILDQSISSFMRKGT HHHHHHHHHHHHCCC | 23.83 | 28857561 | |
| 255 | Phosphorylation | ILDQSISSFMRKGTV HHHHHHHHHHHCCCC | 22.76 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ST1C2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ST1C2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ST1C2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ST1A1_HUMAN | SULT1A1 | physical | 26186194 | |
| ST1C4_HUMAN | SULT1C4 | physical | 26186194 | |
| ST1A1_HUMAN | SULT1A1 | physical | 28514442 | |
| ST1C4_HUMAN | SULT1C4 | physical | 28514442 | |
| ST1A3_HUMAN | SULT1A3 | physical | 28514442 | |
| ST1A4_HUMAN | SULT1A3 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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