ST1A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ST1A3_HUMAN
• UniProt AC: P0DMM9
• Protein Name: Sulfotransferase 1A3
• Gene Name: SULT1A3
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Subcellular Localization: Cytoplasm.
• Protein Description: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs..
• Protein Sequence: MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	RPPLEYVKGVPLIKY CCCCHHHCCCHHHHH	53.97	-
16	Ubiquitination	RPPLEYVKGVPLIKY CCCCHHHCCCHHHHH	53.97	-
76	Phosphorylation	KCNRAPIYVRVPFLE HCCCCCEEEECCEEE	4.91	-
97	Ubiquitination	PSGLETLKDTPPPRL CCCHHHCCCCCCCCH	67.96	21906983
97	Ubiquitination	PSGLETLKDTPPPRL CCCHHHCCCCCCCCH	67.96	-
106	Ubiquitination	TPPPRLIKSHLPLAL CCCCCHHHHCCCHHH	36.09	-
106	Acetylation	TPPPRLIKSHLPLAL CCCCCHHHHCCCHHH	36.09	69735
117	Phosphorylation	PLALLPQTLLDQKVK CHHHCCHHHHCCCEE	27.61	-
122	Ubiquitination	PQTLLDQKVKVVYVA CHHHHCCCEEEEEEE	43.63	-
124	Ubiquitination	TLLDQKVKVVYVARN HHHCCCEEEEEEECC	32.78	-
139	Phosphorylation	PKDVAVSYYHFHRME HHHHEEEHEEHHHHH	8.38	20068231
140	Phosphorylation	KDVAVSYYHFHRMEK HHHEEEHEEHHHHHH	7.18	20068231
193	Phosphorylation	HPVLYLFYEDMKENP CCEEHHCHHHHHHCH	14.39	21253578
228	Phosphorylation	DFMVQHTSFKEMKKN HHHHHCCCHHHHHCC	32.00	24275569
251	Phosphorylation	PQELMDHSISPFMRK CHHHHCCCCCHHHHC	22.09	20068231
253	Phosphorylation	ELMDHSISPFMRKGM HHHCCCCCHHHHCCC	18.33	20068231
283	Ubiquitination	FDADYAEKMAGCSLS CCHHHHHHHCCCCEE	26.36	-
288	Phosphorylation	AEKMAGCSLSFRSEL HHHHCCCCEEECCCC	26.57	20873877
290	Phosphorylation	KMAGCSLSFRSEL-- HHCCCCEEECCCC--	11.43	20873877
293	Phosphorylation	GCSLSFRSEL----- CCCEEECCCC-----	41.04	26434776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ST1A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ST1A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ST1A3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NIF3L_HUMAN	NIF3L1	physical	25416956
KHDR2_HUMAN	KHDRBS2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.