TYB4Y_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYB4Y_HUMAN
• UniProt AC: O14604
• Protein Name: Thymosin beta-4, Y-chromosomal
• Gene Name: TMSB4Y
• Organism: Homo sapiens (Human).
• Sequence Length: 44
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)..
• Protein Sequence: MSDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDKPGMAE ------CCCCCCHHH	55.10	29396449
4	Acetylation	----MSDKPGMAEIE ----CCCCCCHHHHH	35.84	23749302
12	Acetylation	PGMAEIEKFDKSKLK CCHHHHHHHCHHHHC	65.60	23749302
15	Acetylation	AEIEKFDKSKLKKTE HHHHHHCHHHHCCCC	53.26	21339330
16	Phosphorylation	EIEKFDKSKLKKTET HHHHHCHHHHCCCCC	45.10	26074081
17	Acetylation	IEKFDKSKLKKTETQ HHHHCHHHHCCCCCC	70.80	21466224
19	Acetylation	KFDKSKLKKTETQEK HHCHHHHCCCCCCCC	62.48	21466224
21	Phosphorylation	DKSKLKKTETQEKNP CHHHHCCCCCCCCCC	42.55	26074081
23	Phosphorylation	SKLKKTETQEKNPLS HHHCCCCCCCCCCCC	47.46	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYB4Y_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYB4Y_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYB4Y_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TYB4Y_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.