| UniProt ID | TRPC5_HUMAN | |
|---|---|---|
| UniProt AC | Q9UL62 | |
| Protein Name | Short transient receptor potential channel 5 | |
| Gene Name | TRPC5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 973 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.. | |
| Protein Sequence | MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 193 | Phosphorylation | EVDSLRHSRSRLNIY HHHHHHHHHHHHHHH | 26.05 | 17081983 | |
| 195 | Phosphorylation | DSLRHSRSRLNIYKA HHHHHHHHHHHHHHH | 44.10 | 20068231 | |
| 200 | Phosphorylation | SRSRLNIYKALASPS HHHHHHHHHHHHCCC | 6.80 | 24260401 | |
| 205 | Phosphorylation | NIYKALASPSLIALS HHHHHHHCCCEEEEC | 18.83 | - | |
| 207 | Phosphorylation | YKALASPSLIALSSE HHHHHCCCEEEECCC | 29.88 | - | |
| 231 | Phosphorylation | GWELKELSKVENEFK CCHHHHHHHHCHHHH | 35.43 | - | |
| 333 | Phosphorylation | HWVVKLLTCMTIGFL HHHHHHHHHHHHHHH | 15.63 | 28857561 | |
| 336 | Phosphorylation | VKLLTCMTIGFLFPM HHHHHHHHHHHHHHH | 21.79 | 28857561 | |
| 348 | Phosphorylation | FPMLSIAYLISPRSN HHHHHHHHHHCCCCC | 11.69 | 28857561 | |
| 351 | Phosphorylation | LSIAYLISPRSNLGL HHHHHHHCCCCCCCH | 16.21 | 24719451 | |
| 461 | N-linked_Glycosylation | IVAYVKYNGSRPREE EEEEEECCCCCCHHH | 35.92 | UniProtKB CARBOHYD | |
| 489 | Phosphorylation | FAISNILSSLRLISL HHHHHHHHHHHHHHH | 24.43 | 17081983 | |
| 490 | Phosphorylation | AISNILSSLRLISLF HHHHHHHHHHHHHHH | 17.67 | 25954137 | |
| 524 | Phosphorylation | ILKFLFIYCLVLLAF HHHHHHHHHHHHHHH | 3.41 | 18083107 | |
| 553 | S-nitrosylation | AIDEPNNCKGIRCEK CCCCCCCCCCCCCCC | 5.62 | 22178444 | |
| 553 | S-nitrosocysteine | AIDEPNNCKGIRCEK CCCCCCCCCCCCCCC | 5.62 | - | |
| 558 | S-nitrosylation | NNCKGIRCEKQNNAF CCCCCCCCCCCCCHH | 7.87 | 22178444 | |
| 558 | S-nitrosocysteine | NNCKGIRCEKQNNAF CCCCCCCCCCCCCHH | 7.87 | - | |
| 586 | Phosphorylation | VFGLLNLYVTNVKAR HHHHHHHHHCCHHHH | 12.26 | - | |
| 628 | Phosphorylation | IAMMNNSYQLIADHA HHHHCCCHHHHHHHC | 14.95 | - | |
| 755 | Phosphorylation | QDISSFRYEVLDLLG HHHHHHHHHHHHHHC | 14.37 | 22817900 | |
| 769 | Phosphorylation | GNRKHPRSFSTSSTE CCCCCCCCCCCCCCC | 28.18 | 22210691 | |
| 794 | Phosphorylation | SGGARAKSKSVSFNL CCCHHCCCCEEEEEE | 29.22 | 21734191 | |
| 796 | Phosphorylation | GARAKSKSVSFNLGC CHHCCCCEEEEEECC | 30.04 | 21734191 | |
| 850 | Phosphorylation | KKLGLLFSKFNGHMS HHHHHHHHCCCCCCC | 35.99 | 24719451 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRPC5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRPC5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| STMN3_HUMAN | STMN3 | physical | 12858178 | |
| STMN1_HUMAN | STMN1 | physical | 12858178 | |
| STMN2_HUMAN | STMN2 | physical | 12858178 | |
| STMN4_HUMAN | STMN4 | physical | 12858178 | |
| TRPC6_HUMAN | TRPC6 | physical | 12857742 | |
| TRPC3_HUMAN | TRPC3 | physical | 12857742 | |
| TRPC1_HUMAN | TRPC1 | physical | 12857742 | |
| TRPC4_HUMAN | TRPC4 | physical | 12032305 | |
| TAF9_HUMAN | TAF9 | physical | 28514442 | |
| SC24B_HUMAN | SEC24B | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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