STMN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STMN3_HUMAN
• UniProt AC: Q9NZ72
• Protein Name: Stathmin-3
• Gene Name: STMN3
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Golgi apparatus . Cell projection, growth cone . Cell projection, axon .
• Protein Description: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3..
• Protein Sequence: MASTISAYKEKMKELSVLSLICSCFYTQPHPNTVYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPMLSSPPKKKDTSLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHKALEENNNFSRQAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASTISAYKE -----CCCHHHHHHH	25.60	29507054
4	Phosphorylation	----MASTISAYKEK ----CCCHHHHHHHH	14.93	29507054
6	Phosphorylation	--MASTISAYKEKMK --CCCHHHHHHHHHH	26.15	29507054
8	Phosphorylation	MASTISAYKEKMKEL CCCHHHHHHHHHHHH	16.94	29507054
9	Ubiquitination	ASTISAYKEKMKELS CCHHHHHHHHHHHHH	51.04	23000965
11	Ubiquitination	TISAYKEKMKELSVL HHHHHHHHHHHHHHH	51.63	23000965
13	Ubiquitination	SAYKEKMKELSVLSL HHHHHHHHHHHHHHH	67.58	23000965
22	S-palmitoylation	LSVLSLICSCFYTQP HHHHHHHHHHHHCCC	3.34	-
24	S-palmitoylation	VLSLICSCFYTQPHP HHHHHHHHHHCCCCC	2.34	-
26	Phosphorylation	SLICSCFYTQPHPNT HHHHHHHHCCCCCCC	14.59	18083107
35	Phosphorylation	QPHPNTVYQYGDMEV CCCCCCEEEECCEEH	8.25	18083107
37	Phosphorylation	HPNTVYQYGDMEVKQ CCCCEEEECCEEHHH	9.45	18083107
39	Phosphorylation	NTVYQYGDMEVKQLD CCEEEECCEEHHHHC	25.74	32142685
48	Ubiquitination	EVKQLDKRASGQSFE EHHHHCCCCCCCCEE	33.38	-
50	Phosphorylation	KQLDKRASGQSFEVI HHHCCCCCCCCEEEE	41.20	30266825
53	Phosphorylation	DKRASGQSFEVILKS CCCCCCCCEEEEECC	27.22	25849741
57	Phosphorylation	SGQSFEVILKSPSDL CCCCEEEEECCHHHC	2.93	32142685
59	Ubiquitination	QSFEVILKSPSDLSP CCEEEEECCHHHCCC	49.55	2190698
60	Phosphorylation	SFEVILKSPSDLSPE CEEEEECCHHHCCCC	26.62	22577147
62	Phosphorylation	EVILKSPSDLSPESP EEEECCHHHCCCCCC	59.27	26074081
65	Phosphorylation	LKSPSDLSPESPMLS ECCHHHCCCCCCCCC	31.45	25307156
68	Phosphorylation	PSDLSPESPMLSSPP HHHCCCCCCCCCCCC	20.99	23401153
72	Phosphorylation	SPESPMLSSPPKKKD CCCCCCCCCCCCCCC	34.25	22115753
73	Phosphorylation	PESPMLSSPPKKKDT CCCCCCCCCCCCCCC	41.06	22577147
76	Ubiquitination	PMLSSPPKKKDTSLE CCCCCCCCCCCCCHH	75.69	32142685
78	Acetylation	LSSPPKKKDTSLEEL CCCCCCCCCCCHHHH	72.81	19816331
80	Phosphorylation	SPPKKKDTSLEELQK CCCCCCCCCHHHHHH	44.05	20886841
81	Phosphorylation	PPKKKDTSLEELQKR CCCCCCCCHHHHHHH	43.87	20886841
86	Ubiquitination	DTSLEELQKRLEAAE CCCHHHHHHHHHHHH	31.91	24816145
87	Acetylation	TSLEELQKRLEAAEE CCHHHHHHHHHHHHH	72.13	19816339
87	Ubiquitination	TSLEELQKRLEAAEE CCHHHHHHHHHHHHH	72.13	32142685
97	Ubiquitination	EAAEERRKTQEAQVL HHHHHHHHHHHHHHH	61.86	24816145
98	Phosphorylation	AAEERRKTQEAQVLK HHHHHHHHHHHHHHH	29.81	28555341
138	Phosphorylation	QAEEKLNYKMELSKE HHHHHHHHHHHHHHH	23.34	26356563
179	Phosphorylation	KEQREEMSG------ HHHHHHHCC------	44.63	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
60	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
60	S	Phosphorylation	Kinase	JNK1	P45983	PSP
68	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
68	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
73	S	Phosphorylation	Kinase	CDK5	Q00535	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STMN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STMN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPC5_HUMAN	TRPC5	physical	12858178

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.