TRPC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPC1_HUMAN
• UniProt AC: P48995
• Protein Name: Short transient receptor potential channel 1
• Gene Name: TRPC1
• Organism: Homo sapiens (Human).
• Sequence Length: 793
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion..
• Protein Sequence: MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
206	Phosphorylation	SAKNKKDSLRHSRFR CCCCCHHCCCCCHHH	35.86	-
229	Phosphorylation	SPALIMLTEEDPILR CCEEEEECCCCHHHH	21.68	-
279	Phosphorylation	LLAQARNSRELEVIL HHHHHHCCCCCCHHH	22.90	-
289	Phosphorylation	LEVILNHTSSDEPLD CCHHHHCCCCCCCCC	28.93	-
308	Phosphorylation	LEERMNLSRLKLAIK HHHHHCHHHHHHHHH	30.48	-
347	Phosphorylation	SGYRRKPTCKKIMTV CCCCCCCHHHHHHHH	39.74	-
368	Phosphorylation	WPVLSLCYLIAPKSQ HHHHHHHHHHCCHHH	13.36	19835603
415	Phosphorylation	YNEDKKNTMGPALER CCCCCCCCCCHHHHH	32.17	29632367
425	Phosphorylation	PALERIDYLLILWII HHHHHHHHHHHHHHH	10.88	-
690	Ubiquitination	NIIPSPKTICYMISS CCCCCHHHHHHHHHH	21.47	30230243
724	Ubiquitination	LKEWRNLKQKRDENY HHHHHHHHHHHCHHH	58.27	30230243
752	Phosphorylation	SMRQKMQSTDQATVE HHHHHHHCCCHHHHH	30.38	-
757	Phosphorylation	MQSTDQATVENLNEL HHCCCHHHHHHHHHH	23.79	-
783	Phosphorylation	RDLLGFRTSKYAMFY HHHHCCCCCCCCCCC	27.58	29514088
784	Phosphorylation	DLLGFRTSKYAMFYP HHHCCCCCCCCCCCC	21.29	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
206	S	Phosphorylation	Kinase	PKG1	Q13976	PSP
347	T	Phosphorylation	Kinase	PKG1	Q13976	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRPC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRM1_HUMAN	GRM1	physical	14614461
TRPC6_HUMAN	TRPC6	physical	12857742
TRPC3_HUMAN	TRPC3	physical	12857742
TRPC4_HUMAN	TRPC4	physical	12032305
TRPC1_HUMAN	TRPC1	physical	12032305
TRPC5_HUMAN	TRPC5	physical	12032305
PKD2_HUMAN	PKD2	physical	10097141
ITPR3_HUMAN	ITPR3	physical	10980191
CAV1_HUMAN	CAV1	physical	10980191
TRPC3_HUMAN	TRPC3	physical	9215637

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.