TRPC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPC3_HUMAN
• UniProt AC: Q13507
• Protein Name: Short transient receptor potential channel 3
• Gene Name: TRPC3
• Organism: Homo sapiens (Human).
• Sequence Length: 836
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion..
• Protein Sequence: MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11 (in isoform 3)	Phosphorylation	-	48.68	14983059
11	Phosphorylation	KGRRQAVRGPAFMFN HHHCCCCCCCCEEEC	48.68	-
22	Phosphorylation	FMFNDRGTSLTAEEE EEECCCCCCCCHHHH	22.81	22210691
25	Phosphorylation	NDRGTSLTAEEERFL CCCCCCCCHHHHHHH	31.61	22210691
37	Phosphorylation	RFLDAAEYGNIPVVR HHHHHHHHCCCHHHH	15.67	-
50	Phosphorylation	VRKMLEESKTLNVNC HHHHHHHHCCCCCCH	22.89	22210691
84 (in isoform 2)	Phosphorylation	-	52.37	14983059
99	Phosphorylation	DALLLAISKGYVRIV HHHHHHHHCCCHHHH	17.89	29396449
118	Phosphorylation	NHPGFAASKRLTLSP CCCCCCCCCCEEECC	18.19	24260401
136	Phosphorylation	ELQDDDFYAYDEDGT HHCCCCCEEECCCCC	15.96	-
138	Phosphorylation	QDDDFYAYDEDGTRF CCCCCEEECCCCCEE	14.42	-
161	Phosphorylation	LAAHCQKYEVVHMLL HHHHHCHHHHHHHHH	6.51	29759185
199	Phosphorylation	RHDSFSHSRSRINAY CCCCCCCHHHHHHHH	30.65	-
201	Phosphorylation	DSFSHSRSRINAYKG CCCCCHHHHHHHHCC	40.29	-
211	Phosphorylation	NAYKGLASPAYLSLS HHHCCCCCCHHHCCC	18.33	-
214	Phosphorylation	KGLASPAYLSLSSED CCCCCCHHHCCCCCC	10.54	-
251	Phosphorylation	KNDYRKLSMQCKDFV HHHHHHHHHHHHHHH	15.16	14983059
263	Phosphorylation	DFVVGVLDLCRDSEE HHHHHHHHHHCCHHH	41.12	-
293	Phosphorylation	EVHRHKASLSRVKLA HHHCCCCCHHHHHHH	31.51	27174698
295	Phosphorylation	HRHKASLSRVKLAIK HCCCCCHHHHHHHHH	32.31	27174698
327	Phosphorylation	TIWYENLSGLREQTI HHHHHCCCCHHHHHH	47.57	24719451
380	Phosphorylation	KFVAHAASFIIFLGL HHHHHHHHHHHHHHH	20.12	26074081
404	N-linked_Glycosylation	EGITTLPNITVTDYP CCCCCCCCEEECCCC	45.75	9535843
537	Phosphorylation	YAIAVVLSFSRIAYI HHHHHHHHHHHEEEE	15.01	-
543	Phosphorylation	LSFSRIAYILPANES HHHHHEEEEEECCCC	10.71	-
561	Phosphorylation	LQISLGRTVKDIFKF CCCCCCCHHHHHHHH	30.06	-
669	Phosphorylation	YQEIEDDSDVEWKFA CCCCCCCCCCCHHHH	56.74	-
696	Phosphorylation	KTLPPPFSLVPSPKS CCCCCCCCCCCCCHH	33.94	-
700	Phosphorylation	PPFSLVPSPKSFVYF CCCCCCCCCHHHHHH	37.16	21815630
703	Phosphorylation	SLVPSPKSFVYFIMR CCCCCCHHHHHHHHH	24.27	24719451
706	Phosphorylation	PSPKSFVYFIMRIVN CCCHHHHHHHHHHHC	5.84	24719451
712	Phosphorylation	VYFIMRIVNFPKCRR HHHHHHHHCCHHHHH	4.21	16331690
735	Phosphorylation	MGMGNSKSRLNLFTQ CCCCCCHHHHHHHHC	41.65	24114839
752	Phosphorylation	SRVFESHSFNSILNQ CCEECCCCHHHHHCC	35.09	-
788 (in isoform 2)	Phosphorylation	-	49.89	24719451
791 (in isoform 2)	Phosphorylation	-	50.95	24719451
800	Phosphorylation	KEIKQDISSLRYELL HHHHHHHHHHHHHHH	31.45	24719451
801	Phosphorylation	EIKQDISSLRYELLE HHHHHHHHHHHHHHC	19.73	25954137
804	Phosphorylation	QDISSLRYELLEDKS HHHHHHHHHHHCCHH	19.07	-
831	Phosphorylation	LSEKLNPSMLRCE-- HHHHHCHHHHCCC--	29.40	19276368

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
11	T	Phosphorylation	Kinase	PRKG1	Q13976	GPS
37	Y	Phosphorylation	Kinase	SRC	P00523	PSP
136	Y	Phosphorylation	Kinase	SRC	P00523	PSP
138	Y	Phosphorylation	Kinase	SRC	P00523	PSP
214	Y	Phosphorylation	Kinase	SRC	P00523	PSP
251	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS
561	T	Phosphorylation	Kinase	PKCG	P05129	PSP
700	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
712	S	Phosphorylation	Kinase	KPCA	P17252	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRPC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPC3_HUMAN	TRPC3	physical	12032305
TRPC6_HUMAN	TRPC6	physical	12032305
TRPC7_HUMAN	TRPC7	physical	12032305

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616410: Spinocerebellar ataxia 41 (SCA41)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.