dbPTM

TRPC7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRPC7_HUMAN
UniProt AC	Q9HCX4
Protein Name	Short transient receptor potential channel 7
Gene Name	TRPC7
Organism	Homo sapiens (Human).
Sequence Length	862
Subcellular Localization	Cell membrane Multi-pass membrane protein . Nucleus envelope .
Protein Description	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion..
Protein Sequence	MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MLRNSTFKNMQR ---CCCCCHHHHHHH	28.87	27794612
6	Phosphorylation	--MLRNSTFKNMQRR --CCCCCHHHHHHHH	42.02	27794612
15	Phosphorylation	KNMQRRHTTLREKGR HHHHHHHHHHHHHHH	26.22	21402151
16	Phosphorylation	NMQRRHTTLREKGRR HHHHHHHHHHHHHHH	20.07	-
211	Phosphorylation	TEKQRKDSFSHSRSR CHHHCHHCCCCHHHH	31.51	-
215	Phosphorylation	RKDSFSHSRSRMNAY CHHCCCCHHHHHHHH	30.65	-
217	Phosphorylation	DSFSHSRSRMNAYKG HCCCCHHHHHHHHHH	38.61	-
222	Phosphorylation	SRSRMNAYKGLASAA HHHHHHHHHHHHHHH	10.69	-
267	Phosphorylation	KNDYRKLSMQCKDFV HHHHHHHHHHHHHHH	15.16	14983059
341	Phosphorylation	TMWYENLSGLRQQSI HHHHHCCCCHHHHHH	47.57	24719451
415	Phosphorylation	DRFEGVKTLPNETFT HCCCCCCCCCCCCCC	45.07	-
420	Phosphorylation	VKTLPNETFTDYPKQ CCCCCCCCCCCCCCC	38.18	-
424	Phosphorylation	PNETFTDYPKQIFRV CCCCCCCCCCCCEEC	14.85	-
514	N-linked_Glycosylation	VQDDTLHNVSLPPEV CCCCCCCCCCCCHHH	28.34	UniProtKB CARBOHYD
523	Phosphorylation	SLPPEVAYFTYARDK CCCHHHHEEEECCCC	11.13	18452278
525	Phosphorylation	PPEVAYFTYARDKWW CHHHHEEEECCCCCC	12.00	18452278
526	Phosphorylation	PEVAYFTYARDKWWP HHHHEEEECCCCCCC	6.96	18452278
551	Phosphorylation	YAIAVVLSFSRIAYI HHHHHHHHHHHEEEE	15.01	-
557	Phosphorylation	LSFSRIAYILPANES HHHHHEEEEEECCCC	10.71	-
575	Phosphorylation	LQISLGRTVKDIFKF CCCCCCCHHHHHHHH	30.06	-
601	Phosphorylation	MIGMFNLYSYYRGAK HHHHHHHHHHHHCCC	8.84	24043423
602	Phosphorylation	IGMFNLYSYYRGAKY HHHHHHHHHHHCCCC	20.89	24043423
603	Phosphorylation	GMFNLYSYYRGAKYN HHHHHHHHHHCCCCC	5.43	24043423
604	Phosphorylation	MFNLYSYYRGAKYNP HHHHHHHHHCCCCCC	9.16	24043423
714	Phosphorylation	APFNLVPSPKSFYYL CCCCCCCCCHHHHHH	37.16	21815630
739	Phosphorylation	LCKSKAKSCENDLEM HHHHHHHHCCCHHHH	31.36	29759185
751	Phosphorylation	LEMGMLNSKFKKTRY HHHHHHHHHHHHHHH	35.19	26546556
775	Phosphorylation	LTANNTLSKPTRYQK CCCCCCCCCCHHHHH	34.25	18452278
778	Phosphorylation	NNTLSKPTRYQKIMK CCCCCCCHHHHHHHH	45.83	18452278
817	Phosphorylation	KEIKQDISSLRYELL HHHHHHHHHHHHHHH	31.45	24719451
818	Phosphorylation	EIKQDISSLRYELLE HHHHHHHHHHHHHHH	19.73	25954137
821	Phosphorylation	QDISSLRYELLEEKS HHHHHHHHHHHHHHH	19.07	-
842	Phosphorylation	ADLIQQLSEKFGKNL HHHHHHHHHHHCHHC	34.11	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
15	T	Phosphorylation	Kinase	PRKG1	Q13976	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	T	Phosphorylation		21402151
Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRPC7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TRPC7_HUMAN	TRPC7	physical	12032305

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRPC7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Functional regulation of transient receptor potential canonical 7 bycGMP-dependent protein kinase Ialpha."; Yuasa K., Matsuda T., Tsuji A.; Cell. Signal. 23:1179-1187(2011). Cited for: PHOSPHORYLATION AT THR-15 BY PRKG1, INTERACTION WITH PRKG1, ANDSUBCELLULAR LOCATION.	21402151 [Abstract]

show