HNMT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNMT_HUMAN
• UniProt AC: P50135
• Protein Name: Histamine N-methyltransferase
• Gene Name: HNMT
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Cytoplasm .
• Protein Description: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine..
• Protein Sequence: MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	SSMRSLFSDHGKYVE CHHHHHHCCCCHHHH	33.71	22985185
52	Phosphorylation	GRIGDTKSEIKILSI CCCCCCCCEEEEEEE	46.80	22798277
72	Phosphorylation	EIDLQILSKVQAQYP HHHHHHHHHHHHCCC	32.20	24719451
78 (in isoform 2)	Phosphorylation	-	12.64	-
84 (in isoform 2)	Phosphorylation	-	33.22	-
99	Ubiquitination	AEQIAKYKELVAKTS HHHHHHHHHHHHHHC	43.81	-
104	Ubiquitination	KYKELVAKTSNLENV HHHHHHHHHCCCCCE	45.03	-
112	Acetylation	TSNLENVKFAWHKET HCCCCCEEEEEECCC	40.73	23236377
114 (in isoform 2)	Phosphorylation	-	11.18	15302935
119	Phosphorylation	KFAWHKETSSEYQSR EEEEECCCCHHHHHH	42.21	22210691
120	Phosphorylation	FAWHKETSSEYQSRM EEEECCCCHHHHHHH	23.43	22210691
121	Phosphorylation	AWHKETSSEYQSRML EEECCCCHHHHHHHH	47.98	22210691
130	Ubiquitination	YQSRMLEKKELQKWD HHHHHHHHHHHHHHH	47.81	-
131	Ubiquitination	QSRMLEKKELQKWDF HHHHHHHHHHHHHHH	55.04	-
160	Phosphorylation	ATLKFFHSLLGTNAK HHHHHHHHHHCCCCE	21.82	23312004
164	Phosphorylation	FFHSLLGTNAKMLII HHHHHHCCCCEEEEE	31.79	23312004
174	Phosphorylation	KMLIIVVSGSSGWDK EEEEEEEECCCHHHH	23.28	-
176	Phosphorylation	LIIVVSGSSGWDKLW EEEEEECCCHHHHHH	20.40	-
177	Phosphorylation	IIVVSGSSGWDKLWK EEEEECCCHHHHHHH	47.64	-
284	Phosphorylation	GKVLFNNTLSFIVIE CEEEECCEEEEEEEE	25.53	23186163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNMT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNMT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNMT_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HNMT_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.