DOCK2_HUMAN - dbPTM
DOCK2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOCK2_HUMAN
UniProt AC Q92608
Protein Name Dedicator of cytokinesis protein 2
Gene Name DOCK2
Organism Homo sapiens (Human).
Sequence Length 1830
Subcellular Localization Endomembrane system
Peripheral membrane protein . Cytoplasm, cytoskeleton . Colocalizes with F-actin.
Protein Description Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2..
Protein Sequence MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVTAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSDEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQDAAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48PhosphorylationCGDWYRGYLIKHKML
CCCHHHHHHHHHHHH		9.03-
51AcetylationWYRGYLIKHKMLQGI
HHHHHHHHHHHHCCC		34.2825953088
51UbiquitinationWYRGYLIKHKMLQGI
HHHHHHHHHHHHCCC		34.28-
53AcetylationRGYLIKHKMLQGIFP
HHHHHHHHHHCCCCC		35.9825953088
53UbiquitinationRGYLIKHKMLQGIFP
HHHHHHHHHHCCCCC		35.98-
61UbiquitinationMLQGIFPKSFIHIKE
HHCCCCCCCEEEEEE		47.4521890473
62PhosphorylationLQGIFPKSFIHIKEV
HCCCCCCCEEEEEEE		29.6629083192
67AcetylationPKSFIHIKEVTVEKR
CCCEEEEEEEEEECC		31.7819608861
67UbiquitinationPKSFIHIKEVTVEKR
CCCEEEEEEEEEECC		31.7819608861
70PhosphorylationFIHIKEVTVEKRRNT
EEEEEEEEEECCCCC		24.8429083192
96 (in isoform 2)Ubiquitination-9.3721890473
110UbiquitinationKQLYVASKKERFLQV
HHHHHHCHHHHHHHH		49.25-
111UbiquitinationQLYVASKKERFLQVQ
HHHHHCHHHHHHHHH		52.18-
119PhosphorylationERFLQVQSMMYDLME
HHHHHHHHHHHHHHH		13.4730206219
122PhosphorylationLQVQSMMYDLMEWRS
HHHHHHHHHHHHHHH		9.4028122231
128 (in isoform 2)Ubiquitination-10.9621890473
135PhosphorylationRSQLLSGTLPKDELK
HHHHHHCCCCHHHHH		36.1928122231
138UbiquitinationLLSGTLPKDELKELK
HHHCCCCHHHHHHHH		67.93-
140 (in isoform 2)Ubiquitination-68.7921890473
145AcetylationKDELKELKQKVTSKI
HHHHHHHHHHHHHHC		49.527676559
145UbiquitinationKDELKELKQKVTSKI
HHHHHHHHHHHHHHC		49.52-
151AcetylationLKQKVTSKIDYGNKI
HHHHHHHHCCCCCCE		30.177676569
151UbiquitinationLKQKVTSKIDYGNKI
HHHHHHHHCCCCCCE		30.17-
199UbiquitinationDKITERIKEEMSKDQ
HHHHHHHHHHHCCCC		54.57-
203PhosphorylationERIKEEMSKDQPDYA
HHHHHHHCCCCCCCH		36.0429978859
204UbiquitinationRIKEEMSKDQPDYAM
HHHHHHCCCCCCCHH		60.10-
209PhosphorylationMSKDQPDYAMYSRIS
HCCCCCCCHHHHHCC		10.4321082442
212PhosphorylationDQPDYAMYSRISSSP
CCCCCHHHHHCCCCC		6.1421082442
213PhosphorylationQPDYAMYSRISSSPT
CCCCHHHHHCCCCCC		15.2828796482
216PhosphorylationYAMYSRISSSPTHSL
CHHHHHCCCCCCCEE		24.5330108239
217PhosphorylationAMYSRISSSPTHSLY
HHHHHCCCCCCCEEE		37.6630108239
218PhosphorylationMYSRISSSPTHSLYV
HHHHCCCCCCCEEEE		27.3330108239
220PhosphorylationSRISSSPTHSLYVFV
HHCCCCCCCEEEEEE		26.5030108239
222PhosphorylationISSSPTHSLYVFVRN
CCCCCCCEEEEEEHH		24.7130108239
244 (in isoform 2)Ubiquitination-3.6421890473
268UbiquitinationWGSRGFPKEIEMLNN
CCCCCCCHHHHHHHC		69.8921890473
268 (in isoform 1)Ubiquitination-69.8921890473
277UbiquitinationIEMLNNLKVVFTDLG
HHHHHCCEEEEEECC		38.18-
281PhosphorylationNNLKVVFTDLGNKDL
HCCEEEEEECCCCCC		20.7824719451
286UbiquitinationVFTDLGNKDLNRDKI
EEEECCCCCCCHHHH		62.89-
294PhosphorylationDLNRDKIYLICQIVR
CCCHHHHHEEEHHHE		8.8523403867
304AcetylationCQIVRVGKMDLKDTG
EHHHEECCCCCCCCC		26.7819608861
304UbiquitinationCQIVRVGKMDLKDTG
EHHHEECCCCCCCCC		26.7819608861
308UbiquitinationRVGKMDLKDTGAKKC
EECCCCCCCCCCCCC		49.32-
331PhosphorylationGVAVMDITDIIKGKA
CEEEEEHHHHHCCCC		19.51-
335UbiquitinationMDITDIIKGKAESDE
EEHHHHHCCCCCCHH		55.48-
337UbiquitinationITDIIKGKAESDEEK
HHHHHCCCCCCHHHH		43.93-
344UbiquitinationKAESDEEKQHFIPFH
CCCCHHHHHCCCCCC		47.20-
366UbiquitinationFLHSLLGKVIASKGD
HHHHHHHHHHHCCCC		30.36-
371UbiquitinationLGKVIASKGDSGGQG
HHHHHHCCCCCCCCC		58.6821890473
371 (in isoform 1)Ubiquitination-58.6821890473
385SulfoxidationGLWVTMKMLVGDIIQ
CHHHHHHHHHHHHHH		2.2621406390
395UbiquitinationGDIIQIRKDYPHLVD
HHHHHHHCCCCCCCC		64.34-
397PhosphorylationIIQIRKDYPHLVDRT
HHHHHCCCCCCCCCC		8.7924719451
405PhosphorylationPHLVDRTTVVARKLG
CCCCCCCHHHHHHHC		17.5524719451
410UbiquitinationRTTVVARKLGFPEII
CCHHHHHHHCCCCEE		43.1321890473
410 (in isoform 1)Ubiquitination-43.1321890473
418SulfoxidationLGFPEIIMPGDVRND
HCCCCEECCCCCCCC		3.5921406390
437UbiquitinationLLQGDFDKYNKTTQR
EEECCHHHCCCCCCC		51.20-
440UbiquitinationGDFDKYNKTTQRNVE
CCHHHCCCCCCCCEE		50.27-
471AcetylationICVGAGDKPMNEYRS
EEECCCCCCHHHCEE		45.2925953088
471UbiquitinationICVGAGDKPMNEYRS
EEECCCCCCHHHCEE		45.29-
481PhosphorylationNEYRSVVYYQVKQPR
HHCEEEEEEEECCCC		5.9922817900
482PhosphorylationEYRSVVYYQVKQPRW
HCEEEEEEEECCCCE		8.67-
485UbiquitinationSVVYYQVKQPRWMET
EEEEEEECCCCEEEE		38.77-
494UbiquitinationPRWMETVKVAVPIED
CCEEEEEEEEEEHHH		31.71-
516PhosphorylationFMFRHRSSLESKDKG
HHHHCCCCCCCCCCC		35.7924719451
519PhosphorylationRHRSSLESKDKGEKN
HCCCCCCCCCCCCCC		51.9924719451
525AcetylationESKDKGEKNFAMSYV
CCCCCCCCCCHHHHH		67.0625953088
525UbiquitinationESKDKGEKNFAMSYV
CCCCCCCCCCHHHHH		67.06-
533AcetylationNFAMSYVKLMKEDGT
CCHHHHHHHHHCCCC		34.3325953088
533UbiquitinationNFAMSYVKLMKEDGT
CCHHHHHHHHHCCCC		34.33-
536AcetylationMSYVKLMKEDGTTLH
HHHHHHHHCCCCCCC		64.1925953088
536UbiquitinationMSYVKLMKEDGTTLH
HHHHHHHHCCCCCCC		64.19-
553UbiquitinationFHDLVVLKGDSKKME
CEEEEEEECCCCCCC		49.41-
557MethylationVVLKGDSKKMEDASA
EEEECCCCCCCCCHH		61.96-
558UbiquitinationVLKGDSKKMEDASAY
EEECCCCCCCCCHHH		52.02-
570PhosphorylationSAYLTLPSYRHHVEN
HHHEECHHHHHHHHC		37.6024719451
578UbiquitinationYRHHVENKGATLSRS
HHHHHHCCCCEECCC		36.0921906983
578 (in isoform 1)Ubiquitination-36.0921890473
581PhosphorylationHVENKGATLSRSSSS
HHHCCCCEECCCCCC		33.6624247654
583PhosphorylationENKGATLSRSSSSVG
HCCCCEECCCCCCCC		26.2628674151
585PhosphorylationKGATLSRSSSSVGGL
CCCEECCCCCCCCCC		31.0628674151
586PhosphorylationGATLSRSSSSVGGLS
CCEECCCCCCCCCCC		26.0628674151
587PhosphorylationATLSRSSSSVGGLSV
CEECCCCCCCCCCCC		30.2323401153
588PhosphorylationTLSRSSSSVGGLSVS
EECCCCCCCCCCCCC		27.0822115753
593PhosphorylationSSSVGGLSVSSRDVF
CCCCCCCCCCCCCCE		24.1922115753
595PhosphorylationSVGGLSVSSRDVFSI
CCCCCCCCCCCCEEE		19.1128450419
596PhosphorylationVGGLSVSSRDVFSIS
CCCCCCCCCCCEEEE		30.2828450419
610UbiquitinationSTLVCSTKLTQNVGL
EHHHHCCCCCCCCCH		32.9921906983
610 (in isoform 1)Ubiquitination-32.9921890473
612PhosphorylationLVCSTKLTQNVGLLG
HHHCCCCCCCCCHHH		21.47-
622UbiquitinationVGLLGLLKWRMKPQL
CCHHHHHHHHCCHHH		37.4821890473
622 (in isoform 1)Ubiquitination-37.4821890473
626UbiquitinationGLLKWRMKPQLLQEN
HHHHHHCCHHHHHHH		22.49-
636UbiquitinationLLQENLEKLKIVDGE
HHHHHHHHCCCCCHH		59.24-
638UbiquitinationQENLEKLKIVDGEEV
HHHHHHCCCCCHHHH		52.32-
699PhosphorylationFNTVLEAYIQQHFSA
HHHHHHHHHHHHHHH		7.01-
712UbiquitinationSATLAYKKLMTVLKT
HHHHHHHHHHHHHHH		30.71-
738AcetylationEPILRTLKALEYVFK
HHHHHHHHHHHHHHH		50.7619608861
755PhosphorylationVRSRTLFSQLYEGKE
HHHHHHHHHHHCCHH		23.5324719451
758PhosphorylationRTLFSQLYEGKEQME
HHHHHHHHCCHHHHH		18.2624719451
798PhosphorylationLQVAALKYIPSVLHD
HHHHHHHHCHHHHHC		20.93-
801PhosphorylationAALKYIPSVLHDVEM
HHHHHCHHHHHCHHH		27.96-
835UbiquitinationPVKLQKQKVQSMNEI
CHHHCHHHHHHHHHH		49.64-
838PhosphorylationLQKQKVQSMNEIVQS
HCHHHHHHHHHHHHC		26.9430108239
849UbiquitinationIVQSNLFKKQECRDI
HHHCCCCCHHHHHHC		57.63-
850UbiquitinationVQSNLFKKQECRDIL
HHCCCCCHHHHHHCH		43.95-
863UbiquitinationILLPVITKELKELLE
CHHHHHHHHHHHHHH		50.3421890473
863 (in isoform 1)Ubiquitination-50.3421890473
866UbiquitinationPVITKELKELLEQKD
HHHHHHHHHHHHCCC		47.62-
872UbiquitinationLKELLEQKDDMQHQV
HHHHHHCCCHHHHHH		46.44-
875SulfoxidationLLEQKDDMQHQVLER
HHHCCCHHHHHHHHH		5.7021406390
1006UbiquitinationVFLRAINKFAETMNQ
HHHHHHHHHHHHHHH		39.58-
1054UbiquitinationFSHAKYNKILNKYGD
HCHHHHHHHHHHHHH		45.5421906983
1054 (in isoform 1)Ubiquitination-45.5421890473
1058AcetylationKYNKILNKYGDMRRL
HHHHHHHHHHHHHHH		47.3624699719
1058UbiquitinationKYNKILNKYGDMRRL
HHHHHHHHHHHHHHH		47.3619608861
1076UbiquitinationSIRDMWYKLGQNKIC
EHHHHHHHCCCCEEE		30.5421890473
1076 (in isoform 1)Ubiquitination-30.5421890473
1119PhosphorylationFDMMLCEYQRSGDFK
HHHHHHHHHCCCCCH		14.29-
1127AcetylationQRSGDFKKFENEIIL
HCCCCCHHCCCEEEE		58.8825953088
1127UbiquitinationQRSGDFKKFENEIIL
HCCCCCHHCCCEEEE		58.8821890473
1127 (in isoform 1)Ubiquitination-58.8821890473
1135UbiquitinationFENEIILKLDHEVEG
CCCEEEEEECCCCCC		41.27-
1166PhosphorylationECAAEHPTIAKSVEN
HHHHHCCHHHHHHHH		35.16-
1170PhosphorylationEHPTIAKSVENFVNL
HCCHHHHHHHHHHHH		26.16-
1179UbiquitinationENFVNLVKGLLEKLL
HHHHHHHHHHHHHHH		47.19-
1184UbiquitinationLVKGLLEKLLDYRGV
HHHHHHHHHHHHCCC		55.0821890473
1184 (in isoform 1)Ubiquitination-55.0821890473
1193PhosphorylationLDYRGVMTDESKDNR
HHHCCCCCCCCCCCC		33.9229978859
1196PhosphorylationRGVMTDESKDNRMSC
CCCCCCCCCCCCEEE		48.3929978859
1197AcetylationGVMTDESKDNRMSCT
CCCCCCCCCCCEEEE		57.9025953088
1197UbiquitinationGVMTDESKDNRMSCT
CCCCCCCCCCCEEEE		57.90-
1202PhosphorylationESKDNRMSCTVNLLN
CCCCCCEEEEEEEEH		11.9129978859
1204PhosphorylationKDNRMSCTVNLLNFY
CCCCEEEEEEEEHHH		12.7230108239
1211PhosphorylationTVNLLNFYKDNNREE
EEEEEHHHCCCCCHH		19.1629978859
1220PhosphorylationDNNREEMYIRYLYKL
CCCCHHHHHHHHHHH		5.8719664994
1226UbiquitinationMYIRYLYKLRDLHLD
HHHHHHHHHCCCCCC		34.1621890473
1260PhosphorylationWSDEQCASQVMQTGQ
CCHHHHHHHHHHHCC		30.82-
1290UbiquitinationTIIGYFDKGKMWEEA
HHHHHHHCCHHHHHH		51.00-
1292UbiquitinationIGYFDKGKMWEEAIS
HHHHHCCHHHHHHHH		46.72-
1354PhosphorylationYYGQGFPSFLRNKVF
ECCCCCHHHHHCCEE		34.35-
1359UbiquitinationFPSFLRNKVFIYRGK
CHHHHHCCEEEECCC		31.89-
1387UbiquitinationTQFPNAEKMNTTSAP
HHCCCHHHCCCCCCC		34.73-
1390PhosphorylationPNAEKMNTTSAPGDD
CCHHHCCCCCCCCCC		20.7324275569
1391PhosphorylationNAEKMNTTSAPGDDV
CHHHCCCCCCCCCCC		20.2124275569
1392PhosphorylationAEKMNTTSAPGDDVK
HHHCCCCCCCCCCCC		30.3524275569
1399UbiquitinationSAPGDDVKNAPGQYI
CCCCCCCCCCCCCEE		55.15-
1422UbiquitinationLDEHPRFKNKPVPDQ
CCCCCCCCCCCCCHH		66.40-
1424UbiquitinationEHPRFKNKPVPDQII
CCCCCCCCCCCHHHH		48.2421890473
1424 (in isoform 1)Ubiquitination-48.2421890473
1434PhosphorylationPDQIINFYKSNYVQR
CHHHHHHHHCCCCCC		14.7125147952
1435UbiquitinationDQIINFYKSNYVQRF
HHHHHHHHCCCCCCE		28.2521890473
1435 (in isoform 1)Ubiquitination-28.2521890473
1436PhosphorylationQIINFYKSNYVQRFH
HHHHHHHCCCCCCEE		23.24-
1468PhosphorylationSMWIERTSFVTAYKL
HHHHHHHCCEEHHCC		24.7622985185
1474UbiquitinationTSFVTAYKLPGILRW
HCCEEHHCCCHHHHH		45.8221890473
1474 (in isoform 1)Ubiquitination-45.8221890473
1488PhosphorylationWFEVVHMSQTTISPL
HHEEEECCCCCCCCH		14.97-
1548UbiquitinationGGFAKYEKAFFTEEY
CCHHHHHHHHCCHHH		47.61-
1555PhosphorylationKAFFTEEYVRDHPED
HHHCCHHHHHCCCCH		8.44-
1565UbiquitinationDHPEDQDKLTHLKDL
CCCCHHHHHHHHHHH		50.05-
1570UbiquitinationQDKLTHLKDLIAWQI
HHHHHHHHHHHHHHC		42.77-
1592PhosphorylationKIHEKRVSDNLRPFH
EEEEHHHHCCCCCCH		25.4726657352
1601MethylationNLRPFHDRMEECFKN
CCCCCHHHHHHHHHH		26.33-
1607AcetylationDRMEECFKNLKMKVE
HHHHHHHHHHHHHHH		73.3825953088
1607UbiquitinationDRMEECFKNLKMKVE
HHHHHHHHHHHHHHH		73.38-
1610UbiquitinationEECFKNLKMKVEKEY
HHHHHHHHHHHHHHH		46.17-
1612UbiquitinationCFKNLKMKVEKEYGV
HHHHHHHHHHHHHCC		45.73-
1615UbiquitinationNLKMKVEKEYGVREM
HHHHHHHHHHCCCCC		60.26-
1617PhosphorylationKMKVEKEYGVREMPD
HHHHHHHHCCCCCCC		31.80-
1635PhosphorylationRRVGRPRSMLRSYRQ
CCCCCCHHHHHHHHH		25.5021722762
1639PhosphorylationRPRSMLRSYRQMSII
CCHHHHHHHHHHCHH		22.2427251275
1644PhosphorylationLRSYRQMSIISLASM
HHHHHHHCHHHHHCC		14.3926074081
1647PhosphorylationYRQMSIISLASMNSD
HHHHCHHHHHCCCCC		19.0630576142
1650PhosphorylationMSIISLASMNSDCST
HCHHHHHCCCCCCCC		24.6426074081
1653PhosphorylationISLASMNSDCSTPSK
HHHHCCCCCCCCCCC		31.2126074081
1656PhosphorylationASMNSDCSTPSKPTS
HCCCCCCCCCCCCCC		48.6330576142
1657PhosphorylationSMNSDCSTPSKPTSE
CCCCCCCCCCCCCCC		37.6030576142
1659PhosphorylationNSDCSTPSKPTSESF
CCCCCCCCCCCCCCC		51.8927251275
1662PhosphorylationCSTPSKPTSESFDLE
CCCCCCCCCCCCCCE		49.1927251275
1663PhosphorylationSTPSKPTSESFDLEL
CCCCCCCCCCCCCEE		39.5127251275
1665PhosphorylationPSKPTSESFDLELAS
CCCCCCCCCCCEECC		24.6727251275
1672PhosphorylationSFDLELASPKTPRVE
CCCCEECCCCCCCCC		39.2826074081
1675PhosphorylationLELASPKTPRVEQEE
CEECCCCCCCCCCCC		21.5126074081
1685PhosphorylationVEQEEPISPGSTLPE
CCCCCCCCCCCCCCH		33.6423401153
1688PhosphorylationEEPISPGSTLPEVKL
CCCCCCCCCCCHHHC		30.1020058876
1689PhosphorylationEPISPGSTLPEVKLR
CCCCCCCCCCHHHCC		52.8520058876
1694UbiquitinationGSTLPEVKLRRSKKR
CCCCCHHHCCCCCCC		34.32-
1698PhosphorylationPEVKLRRSKKRTKRS
CHHHCCCCCCCCCCC		35.77-
1702PhosphorylationLRRSKKRTKRSSVVF
CCCCCCCCCCCCEEE		39.4230576142
1705PhosphorylationSKKRTKRSSVVFADE
CCCCCCCCCEEECCH		29.1023401153
1706PhosphorylationKKRTKRSSVVFADEK
CCCCCCCCEEECCHH		26.7423401153
1713UbiquitinationSVVFADEKAAAESDL
CEEECCHHHHHHHHH		43.82-
1718PhosphorylationDEKAAAESDLKRLSR
CHHHHHHHHHHHHHH		43.4421949786
1721UbiquitinationAAAESDLKRLSRKHE
HHHHHHHHHHHHHHC		57.17-
1724PhosphorylationESDLKRLSRKHEFMS
HHHHHHHHHHHCCCC		43.2326074081
1726UbiquitinationDLKRLSRKHEFMSDT
HHHHHHHHHCCCCCC		44.07-
1731PhosphorylationSRKHEFMSDTNLSEH
HHHHCCCCCCCCCHH		46.7523401153
1733PhosphorylationKHEFMSDTNLSEHAA
HHCCCCCCCCCHHCC		30.6522115753
1736PhosphorylationFMSDTNLSEHAAIPL
CCCCCCCCHHCCCCH		29.4328348404
1746PhosphorylationAAIPLKASVLSQMSF
CCCCHHHHHHHHCCH		23.2324043423
1749PhosphorylationPLKASVLSQMSFASQ
CHHHHHHHHCCHHCC		22.9824043423
1752PhosphorylationASVLSQMSFASQSMP
HHHHHHCCHHCCCCC		15.2626074081
1755PhosphorylationLSQMSFASQSMPTIP
HHHCCHHCCCCCCHH		22.3026074081
1757PhosphorylationQMSFASQSMPTIPAL
HCCHHCCCCCCHHHH		25.0026074081
1760PhosphorylationFASQSMPTIPALALS
HHCCCCCCHHHHHHH		30.8326074081
1767PhosphorylationTIPALALSVAGIPGL
CHHHHHHHHHCCCCC		12.3326074081
1779PhosphorylationPGLDEANTSPRLSQT
CCCCCCCCCCCHHHH		47.3526074081
1780PhosphorylationGLDEANTSPRLSQTF
CCCCCCCCCCHHHHH		14.0826074081
1784PhosphorylationANTSPRLSQTFLQLS
CCCCCCHHHHHHHCC		28.5823401153
1786PhosphorylationTSPRLSQTFLQLSDG
CCCCHHHHHHHCCCC		23.9628787133
1791PhosphorylationSQTFLQLSDGDKKTL
HHHHHHCCCCCCCCC		26.9623401153
1795UbiquitinationLQLSDGDKKTLTRKK
HHCCCCCCCCCCHHH		53.86-
1796UbiquitinationQLSDGDKKTLTRKKV
HCCCCCCCCCCHHHH		54.21-
1797PhosphorylationLSDGDKKTLTRKKVN
CCCCCCCCCCHHHHH		38.8223401153
1799PhosphorylationDGDKKTLTRKKVNQF
CCCCCCCCHHHHHHH		45.7523401153
1801UbiquitinationDKKTLTRKKVNQFFK
CCCCCCHHHHHHHHH		56.70-
1802UbiquitinationKKTLTRKKVNQFFKT
CCCCCHHHHHHHHHH		43.03-
1808AcetylationKKVNQFFKTMLASKS
HHHHHHHHHHHHCCC		34.0225953088
1808UbiquitinationKKVNQFFKTMLASKS
HHHHHHHHHHHHCCC		34.0221890473
1808 (in isoform 1)Ubiquitination-34.0221890473
1809PhosphorylationKVNQFFKTMLASKSA
HHHHHHHHHHHCCCH		16.56-
1814UbiquitinationFKTMLASKSAEEGKQ
HHHHHHCCCHHHCCC		48.34-
1820UbiquitinationSKSAEEGKQIPDSLS
CCCHHHCCCCCCCCC		48.62-
1825PhosphorylationEGKQIPDSLSTDL--
HCCCCCCCCCCCC--		20.9027690223
1827PhosphorylationKQIPDSLSTDL----
CCCCCCCCCCC----		24.6727690223
1828PhosphorylationQIPDSLSTDL-----
CCCCCCCCCC-----		46.7627690223
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOCK2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOCK2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOCK2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CRKL_HUMANCRKLphysical
12393632
VAV_HUMANVAV1physical
12393632
HNRPK_HUMANHNRNPKphysical
25416956
KRA59_HUMANKRTAP5-9physical
25416956
MDFI_HUMANMDFIphysical
25416956
PLS1_HUMANPLSCR1physical
25416956
CACO2_HUMANCALCOCO2physical
25416956
MTUS2_HUMANMTUS2physical
25416956
CCDB1_HUMANCCNDBP1physical
25416956
KRA92_HUMANKRTAP9-2physical
25416956
KRA94_HUMANKRTAP9-4physical
25416956
KRA42_HUMANKRTAP4-2physical
25416956
K1C40_HUMANKRT40physical
25416956
KHDR2_HUMANKHDRBS2physical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR101_HUMANKRTAP10-1physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616433Immunodeficiency 40 (IMD40)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOCK2_HUMAN

loading...

Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-67; LYS-304; LYS-738 ANDLYS-1058, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-212; SER-588; SER-593;SER-1685 AND SER-1731, AND MASS SPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1685, AND MASSSPECTROMETRY.
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1685, AND MASSSPECTROMETRY.
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-209 AND TYR-212, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory