RGF1C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGF1C_HUMAN
• UniProt AC: Q8N431
• Protein Name: Ras-GEF domain-containing family member 1C
• Gene Name: RASGEF1C
• Organism: Homo sapiens (Human).
• Sequence Length: 466
• Protein Description: Guanine nucleotide exchange factor (GEF)..
• Protein Sequence: MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSILGKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	YIFTFLLSSRLFIEP HHHHHHHHCCCCCCH	18.63	24719451
70	Phosphorylation	IFTFLLSSRLFIEPR HHHHHHHCCCCCCHH	32.73	24719451
316	Phosphorylation	PVSRLKKTWAKVRTA HHHHHHHHHHHHHHC	29.12	-
322	Phosphorylation	KTWAKVRTAKFFILE HHHHHHHHCEEEEEE	36.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGF1C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGF1C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGF1C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S1A7A_HUMAN	S100A7A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.