GAMT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GAMT_HUMAN
• UniProt AC: Q14353
• Protein Name: Guanidinoacetate N-methyltransferase
• Gene Name: GAMT
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Protein Description: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. [PubMed: 26003046]
• Protein Sequence: MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKSKYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAPSATPI ------CCCCCCCCC	49.22	22223895
2	Phosphorylation	------MSAPSATPI ------CCCCCCCCC	49.22	27251275
5	Phosphorylation	---MSAPSATPIFAP ---CCCCCCCCCCCC	44.48	27251275
7	Phosphorylation	-MSAPSATPIFAPGE -CCCCCCCCCCCCCC	22.66	27251275
17	Phosphorylation	FAPGENCSPAWGAAP CCCCCCCCCCCCCCC	29.27	27251275
27	Phosphorylation	WGAAPAAYDAADTHL CCCCCHHHHHHHHHH	14.28	26552605
32	Phosphorylation	AAYDAADTHLRILGK HHHHHHHHHHHHCCC	20.34	27251275
39	Ubiquitination	THLRILGKPVMERWE HHHHHCCCCHHHHCC	30.87	-
60	Ubiquitination	LAAAASSKGGRVLEV HHHHHHCCCCEEEEE	63.99	-
109	Ubiquitination	WAPRQTHKVIPLKGL CCCCCCCEEEECCCH	45.29	-
222	Phosphorylation	VPPADCRYYAFPQMI CCCCHHCCEECCCCC	12.89	17053785
223	Phosphorylation	PPADCRYYAFPQMIT CCCHHCCEECCCCCC	5.17	17053785
235	Ubiquitination	MITPLVTKG------ CCCCCCCCC------	55.96	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GAMT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GAMT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GAMT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYFM_HUMAN	FARS2	physical	26186194
SYFM_HUMAN	FARS2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612736: Cerebral creatine deficiency syndrome 2 (CCDS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00148: Creatine
• DB00536: Guanidine

Related Literatures of Post-Translational Modification

Phosphorylation

"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-222 AND TYR-223, ANDMASS SPECTROMETRY.
PubMed: 17053785