NEXMI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEXMI_HUMAN
• UniProt AC: Q5QGS0
• Protein Name: Neurite extension and migration factor {ECO:0000305}
• Gene Name: NEXMIF {ECO:0000312|HGNC:HGNC:29433}
• Organism: Homo sapiens (Human).
• Sequence Length: 1516
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1)..
• Protein Sequence: MDNQQDKAIVASANGENTLINGVKENDSEDQDVAMKSFAALEAAAPIQPTPVAQKETLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGIAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDAVDPEPGISLKVGDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRRETEKPDIDLEDPAQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKSGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEDKGVEKKDGKDNGEKPALNKPCSGTEVEQLKNPKQGHLANSLETSGSFSDDSSFIEISYDAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPVGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGKVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNTNTDSIKTPFSQKQSFEPGSFEVSFLPPARKRKSKLGNRHRIQRIPSIEISASSKQISLCNDQRHASNHKEDGGLKGTLKSAPLGAPSCANGSHLNDITGPDSVKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKVKAAGQESKPIVQMSPLLENQSSKANLKNEVIPGTSNSSRLSEFHEAKAAKSSTFLPTTCSSEMPLSSANVTTNIPVIPGGYLQTLLDASDLSNNTSISYFSHHSPEQNEGSLTQTEKSFVPLQPTQDCVLTSSSDSELQQSSHNFKMESSNYRNVWPNKATSGTQEFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNCNKVLYDSMQDTQLPSDDSYQLCHFNNGEICFPFQQGPVNMDDGRLFSFDSMAPLSVSSSNYCSLSLKSCEKDGDDDITDDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEMSPPDTPSLSPQITRCESMKTLGTLKGFQEGVPGPLDSVEKIKWDCSTLSRQVQMEDGFTLNNHQFQFHMFNDEDSVSLLQKNPCLSTFNDPSGQISTNNKVSKSRKKSSPSKSGAMNQSSSQKNTRKKSLKGNNKGIEKPPGKNSRQVPKSTKKGKYMAAINGEKMQIGIGRGGSQTNTISSTGKTLAECIQHGGPMASMKMPSQKGLSGDWALGKESSPGWSDMSMGTNTNSLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKINSGSQGATKNHRSIKGVSKSNGKTAIGDPGRANMPGYNEDSRSTFFDKKYSNMSTLGNNGPTHKKLYRHKSSSKALRDEKCKGKHMEREQVHKDESGTASFEKLRDSDYNLLKAETTFWVLPVFEEETRIFQKDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	AAAPIQPTPVAQKET HCCCCCCCCCCCCCC		-
69	Phosphorylation	RGLLPLPSKKPCMQS CCCCCCCCCCCCCCC		24719451
166	Ubiquitination	PEPGISLKVGDLNRD CCCCEEEEEECCCCC		29967540
211	Ubiquitination	LLGFPLHKSRAGDRR HCCCCCCCCCCCCCC		29967540
233	Ubiquitination	DLEDPAQKSYYEALL CCCCHHHHHHHHHHH		29967540
325	Phosphorylation	QDNVRDKTTLLMQED HHHCCCCEEEEECCC		-
326	Phosphorylation	DNVRDKTTLLMQEDA HHCCCCEEEEECCCH		-
350	Phosphorylation	TTCPKRESKSGALKQ CCCCCCCCCCCCCCC		-
356	Ubiquitination	ESKSGALKQSSDFSQ CCCCCCCCCCCCCHH		29967540
471	Phosphorylation	ARDTNSGSSSSQQNY EECCCCCCCCHHHHH		-
478	Phosphorylation	SSSSQQNYGLRAKRK CCCHHHHHCHHCCEE		-
549	Acetylation	YIIINRFKGEKNMLV EEEEECCCCCCCEEE		133027
580	Acetylation	NQLNKYAKLAPLKGF HHHHHHHHHHCCCHH		90649
592	Acetylation	KGFWQKKKKQRNTNT CHHHHHHHHHCCCCC		90653
593	Acetylation	GFWQKKKKQRNTNTD HHHHHHHHHCCCCCC		90657
643	Phosphorylation	HRIQRIPSIEISASS HHCCCCCCEEEEECC		24719451
767	Phosphorylation	KNEVIPGTSNSSRLS CCCCCCCCCCCHHHH		30243723
768	Phosphorylation	NEVIPGTSNSSRLSE CCCCCCCCCCHHHHH		30243723
770	Phosphorylation	VIPGTSNSSRLSEFH CCCCCCCCHHHHHHH		30243723
771	Phosphorylation	IPGTSNSSRLSEFHE CCCCCCCHHHHHHHH		29083192
883	Phosphorylation	HNFKMESSNYRNVWP CCCCCCCCCCCCCCC		-
1008	Phosphorylation	VSSSNYCSLSLKSCE CCCCCCEEEEEECCC		24719451
1010	Phosphorylation	SSNYCSLSLKSCEKD CCCCEEEEEECCCCC		24719451
1031	Phosphorylation	DDFLAHCSPKLVIQQ HHHHHHCCHHHHEEC		30576142
1039	Phosphorylation	PKLVIQQSIDEIAPL HHHHEECCHHHHCCC		28348404
1090	Ubiquitination	ITRCESMKTLGTLKG CEECCCCCCCCCCCC		29967540
1184	Phosphorylation	KKSSPSKSGAMNQSS CCCCCCCCCCCCCCC		28464451
1190	Phosphorylation	KSGAMNQSSSQKNTR CCCCCCCCCCCHHHC		28464451
1191	Phosphorylation	SGAMNQSSSQKNTRK CCCCCCCCCCHHHCC		28464451
1192	Phosphorylation	GAMNQSSSQKNTRKK CCCCCCCCCHHHCCC		28464451
1196	Phosphorylation	QSSSQKNTRKKSLKG CCCCCHHHCCCCCCC		29978859
1200	Phosphorylation	QKNTRKKSLKGNNKG CHHHCCCCCCCCCCC		-
1243	Methylation	KMQIGIGRGGSQTNT EEEEEECCCCCCCCC		115481093
1246	Phosphorylation	IGIGRGGSQTNTISS EEECCCCCCCCCCCC		22210691
1270	Phosphorylation	QHGGPMASMKMPSQK HHCCCCCCCCCCCCC		22210691
1275	Phosphorylation	MASMKMPSQKGLSGD CCCCCCCCCCCCCCC		22210691
1289	Phosphorylation	DWALGKESSPGWSDM CCCCCCCCCCCCCCC		-
1294	Phosphorylation	KESSPGWSDMSMGTN CCCCCCCCCCCCCCC		-
1297	Phosphorylation	SPGWSDMSMGTNTNS CCCCCCCCCCCCCCC		-
1378	Ubiquitination	AGTPQESKKKINSGS CCCCHHHHHHHCCCC		29967540
1385	Phosphorylation	KKKINSGSQGATKNH HHHHCCCCCCCCCCC		25690035
1418	Phosphorylation	GRANMPGYNEDSRST CCCCCCCCCCCCCCC		25954137
1422	Phosphorylation	MPGYNEDSRSTFFDK CCCCCCCCCCCCCCH		25954137
1455	Ubiquitination	YRHKSSSKALRDEKC HCCCCCHHHHHCHHC		32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEXMI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEXMI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEXMI_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NEXMI_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.