| UniProt ID | TBPL1_HUMAN | |
|---|---|---|
| UniProt AC | P62380 | |
| Protein Name | TATA box-binding protein-like protein 1 | |
| Gene Name | TBPL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 186 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.. | |
| Protein Sequence | MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Phosphorylation | LEGANVIYKRDVGKV HCCCCEEEECCHHHH | 8.83 | - | |
| 41 | Ubiquitination | EGANVIYKRDVGKVL CCCCEEEECCHHHHH | 30.88 | - | |
| 78 | Ubiquitination | ATSEEEAKFGARRLA CCCHHHHHHHHHHHH | 47.84 | 30230243 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBPL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBPL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBPL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TF2AA_HUMAN | GTF2A1 | physical | 17353931 | |
| T2AG_HUMAN | GTF2A2 | physical | 17353931 | |
| PMVK_HUMAN | PMVK | physical | 17353931 | |
| TF2B_HUMAN | GTF2B | physical | 10220372 | |
| TF2AA_HUMAN | GTF2A1 | physical | 10570139 | |
| TAF4_HUMAN | TAF4 | physical | 17643375 | |
| T2AG_HUMAN | GTF2A2 | physical | 17643375 | |
| GRP75_HUMAN | HSPA9 | physical | 17643375 | |
| TAF6_HUMAN | TAF6 | physical | 17643375 | |
| TAF5_HUMAN | TAF5 | physical | 17643375 | |
| TAF1L_HUMAN | TAF1L | physical | 17643375 | |
| TAF1_HUMAN | TAF1 | physical | 17643375 | |
| TBP_HUMAN | TBP | physical | 17643375 | |
| TBPL2_HUMAN | TBPL2 | physical | 17643375 | |
| A4_HUMAN | APP | physical | 21832049 | |
| P53_HUMAN | TP53 | physical | 28082682 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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