TAF1L_HUMAN - dbPTM
TAF1L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAF1L_HUMAN
UniProt AC Q8IZX4
Protein Name Transcription initiation factor TFIID subunit 1-like
Gene Name TAF1L
Organism Homo sapiens (Human).
Sequence Length 1826
Subcellular Localization Nucleus.
Protein Description May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced..
Protein Sequence MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDESQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
203PhosphorylationASEKVDFSSYSDSES
HCCCCCCCCCCCCCC		24.7330576142
206PhosphorylationKVDFSSYSDSESEMG
CCCCCCCCCCCCCCC		36.2930576142
218PhosphorylationEMGPQEATQAESEDG
CCCCCCCHHCCCCCC		27.7930576142
222PhosphorylationQEATQAESEDGKLTL
CCCHHCCCCCCCEEE		43.96-
257UbiquitinationFPEFRPGKVLRFLHL
CCCCCCCCEEEEEHH		40.56-
269UbiquitinationLHLFGPGKNVPSVWR
EHHHCCCCCCHHHHH		58.88-
273PhosphorylationGPGKNVPSVWRSARR
CCCCCCHHHHHHHHH		29.9923403867
306PhosphorylationCSVESEVSQKSLWNY
CCCCCCCCCHHHCCC		28.04-
362PhosphorylationPRVAEWRYGPARLWY
CCCEECCCCCCCHHH		28.65-
383PhosphorylationEDGSGFDYGFKLRKT
CCCCCCCCCCEECCC		23.38-
390PhosphorylationYGFKLRKTQHEPVIK
CCCEECCCCCCHHHH		28.8227251275
458PhosphorylationSLAGWLPSIKTRNVM
CCCCCCCCCCCCCCE		34.2524719451
540PhosphorylationPDEKEEATSNSPSKE
CCHHHHHCCCCCCHH		31.5523403867
541PhosphorylationDEKEEATSNSPSKES
CHHHHHCCCCCCHHH		42.2123403867
543PhosphorylationKEEATSNSPSKESKK
HHHHCCCCCCHHHHH		30.2525849741
545PhosphorylationEATSNSPSKESKKES
HHCCCCCCHHHHHHH		49.2123403867
564PhosphorylationSRILLGKTGVIREEP
HHHHHCCCCCCCCCC		34.58-
720UbiquitinationVGMATKIKNYYKRKP
ECCHHHHHHHHHCCC		40.2221890473
724AcetylationTKIKNYYKRKPGKDP
HHHHHHHHCCCCCCC		43.52133933
724UbiquitinationTKIKNYYKRKPGKDP
HHHHHHHHCCCCCCC		43.5232015554
851UbiquitinationIRMEDIKKAFPSHSE
CCHHHHHHHCCCCCH		56.4429967540
874PhosphorylationLCADFKRTGMDSNWW
HHHHHHHHCCCCCEE		37.1321712546
878PhosphorylationFKRTGMDSNWWVLKS
HHHHCCCCCEEEEEC		26.0024260401
926PhosphorylationDAGYGEKSFFAPEEE
HCCCCCCCCCCCCCC		22.6927134283
1005UbiquitinationKEPQAVKKTVTGTDA
CCCCHHHHHHCCCHH		41.45-
1006PhosphorylationEPQAVKKTVTGTDAD
CCCHHHHHHCCCHHH		19.9921406692
1008PhosphorylationQAVKKTVTGTDADLR
CHHHHHHCCCHHHHH		39.3321406692
1010PhosphorylationVKKTVTGTDADLRRL
HHHHHCCCHHHHHHH		20.7421406692
1028UbiquitinationNAKQLLRKFGVPEEE
HHHHHHHHHCCCHHH		46.5729967540
1050PhosphorylationEVIDVVRTMSTEQAH
HHHEEEECCCCCHHC		12.1229083192
1052PhosphorylationIDVVRTMSTEQAHSG
HEEEECCCCCHHCCC		28.3429083192
1053PhosphorylationDVVRTMSTEQAHSGE
EEEECCCCCHHCCCC		22.6929083192
1058PhosphorylationMSTEQAHSGEGPMSK
CCCCHHCCCCCCHHH		41.3729083192
1064PhosphorylationHSGEGPMSKFARGSR
CCCCCCHHHHHCCCC		27.9629083192
1073PhosphorylationFARGSRFSVAEHQER
HHCCCCCCHHHHHHH		21.2128555341
1130UbiquitinationIENMLQNKKTSSQLS
HHHHHHCHHCHHHHH		44.46-
1173PhosphorylationDDVTASMTSLKSSAT
HHCHHHHHHHHHCHH		28.54-
1174PhosphorylationDVTASMTSLKSSATG
HCHHHHHHHHHCHHC		25.76-
1177PhosphorylationASMTSLKSSATGHCL
HHHHHHHHCHHCCEE		30.4221406692
1178PhosphorylationSMTSLKSSATGHCLK
HHHHHHHCHHCCEEE		28.4121406692
1180PhosphorylationTSLKSSATGHCLKIY
HHHHHCHHCCEEEEE		29.4321406692
1187PhosphorylationTGHCLKIYRTFRDEE
HCCEEEEEEEEECCC		11.3021406692
1189PhosphorylationHCLKIYRTFRDEEGK
CEEEEEEEEECCCCC		13.1721406692
1213PhosphorylationKPAVIDAYVRIRTTK
CCEEEEEEEEEEECC		6.1126074081
1218PhosphorylationDAYVRIRTTKDEKFI
EEEEEEEECCCHHHH		35.5126074081
1219PhosphorylationAYVRIRTTKDEKFIQ
EEEEEEECCCHHHHH		27.0126074081
1263AcetylationNQEKEKLKGPPEKKP
HHHHHHHCCCCCCCC		79.1630584373
1325PhosphorylationQEEELEKTVIHNDNE
HHHHHHHHEECCCCC		18.4725627689
1359PhosphorylationVHEVRRKSLVLKFPK
HHHHHHHHHHHCCCH		23.1528450419
1366AcetylationSLVLKFPKQQLPPKK
HHHHCCCHHHCCCCC		54.5330584365
1373AcetylationKQQLPPKKKRRVGTT
HHHCCCCCCCCCCCE		58.2330584369
1379PhosphorylationKKKRRVGTTVHCDYL
CCCCCCCCEEECCCC		23.84-
1385PhosphorylationGTTVHCDYLNIPHKS
CCEEECCCCCCCCHH		13.67-
1398PhosphorylationKSIHRRRTDPMVTLS
HHHCCCCCCCCCHHH		42.52-
1403PhosphorylationRRTDPMVTLSSILES
CCCCCCCHHHHHHHH		18.05-
1410PhosphorylationTLSSILESIINDMRD
HHHHHHHHHHHHHHC		25.8920044836
1441PhosphorylationKDYYKIITRPMDLQT
HHHHHHHHCCCCHHH		31.9923403867
1448PhosphorylationTRPMDLQTLRENVRK
HCCCCHHHHHHHHHH		34.7723403867
1560PhosphorylationKKFVPDYYKMIVNPV
CCCCCCHHHHCCCCC		11.06-
1581PhosphorylationKNISKHKYQSRESFL
HHHHHHHHHCHHHHH		16.08-
1583PhosphorylationISKHKYQSRESFLDD
HHHHHHHCHHHHHHH		34.62-
1652PhosphorylationLEEAELESLDPMTPG
HHHHHHHCCCCCCCC		51.1821406692
1669PhosphorylationTSQPPDMYDTNTSLS
CCCCCCCCCCCCCCC		27.31-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAF1L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAF1L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAF1L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TBP_HUMANTBPphysical
12217962
TAF6_HUMANTAF6physical
22939629
TAF4_HUMANTAF4physical
22939629
TAF5_HUMANTAF5physical
22939629
TAF9_HUMANTAF9physical
22939629
TAF9B_HUMANTAF9Bphysical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAF1L_HUMAN

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Related Literatures of Post-Translational Modification

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