NUD14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUD14_HUMAN
• UniProt AC: O95848
• Protein Name: Uridine diphosphate glucose pyrophosphatase
• Gene Name: NUDT14
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm .
• Protein Description: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose..
• Protein Sequence: MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNSSRRSLVLVKQFRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVTVELCAGLVDQPGLSLEEVACKEAWEECGYHLAPSDLRRVATYWSGVGLTGSRQTMFYTEVTDAQRSGPGGGLVEEGELIEVVHLPLEGAQAFADDPDIPKTLGVIFGVSWFLSQVAPNLDLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MERIEGASVGRCAAS CCCCCCCCCCCCCCC	35.64	23532336
15	Phosphorylation	SVGRCAASPYLRPLT CCCCCCCCCCCCEEE	8.78	23403867
17	Phosphorylation	GRCAASPYLRPLTLH CCCCCCCCCCEEEEE	16.91	23403867
77	Phosphorylation	VERRFPGSLAAVDQD CEECCCCCEEEECCC	18.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUD14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUD14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUD14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUD14_HUMAN	NUDT14	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.