PA1B3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PA1B3_HUMAN
• UniProt AC: Q15102
• Protein Name: Platelet-activating factor acetylhydrolase IB subunit gamma
• Gene Name: PAFAH1B3
• Organism: Homo sapiens (Human).
• Sequence Length: 231
• Subcellular Localization: Cytoplasm.
• Protein Description: Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain..
• Protein Sequence: MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAIVQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGEENPAS ------CCCCCCCCC	55.71	19413330
2	Phosphorylation	------MSGEENPAS ------CCCCCCCCC	55.71	19413330
9	Phosphorylation	SGEENPASKPTPVQD CCCCCCCCCCCCCCC	40.19	27732954
10	Ubiquitination	GEENPASKPTPVQDV CCCCCCCCCCCCCCC	55.83	-
12	Phosphorylation	ENPASKPTPVQDVQG CCCCCCCCCCCCCCC	39.57	25159151
25	Phosphorylation	QGDGRWMSLHHRFVA CCCCCEEEEEEEECC	20.00	28857561
47	Phosphorylation	EVVFIGDSLVQLMHQ CEEEECHHHHHHHHH	25.81	24076635
63	Phosphorylation	EIWRELFSPLHALNF HHHHHHHCHHHHHCE	38.89	28985074
184	Phosphorylation	GFVHSDGTISHHDMY CCCCCCCCCCHHHHH	25.05	-
191	Phosphorylation	TISHHDMYDYLHLSR CCCHHHHHHHHHHHH	13.90	27642862
193	Phosphorylation	SHHDMYDYLHLSRLG CHHHHHHHHHHHHCC	4.40	27642862
210	Phosphorylation	PVCRALHSLLLRLLA HHHHHHHHHHHHHHH	22.89	23911959

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PA1B3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PA1B3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PA1B3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	16189514
PA1B3_HUMAN	PAFAH1B3	physical	16189514
CHMP7_HUMAN	CHMP7	physical	16189514
SDCB2_HUMAN	SDCBP2	physical	16189514
ECH1_HUMAN	ECH1	physical	16169070
GBP2_HUMAN	GBP2	physical	16169070
GDF9_HUMAN	GDF9	physical	16169070
CC90B_HUMAN	CCDC90B	physical	16169070
IGS21_HUMAN	IGSF21	physical	16169070
PKHM1_HUMAN	PLEKHM1	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
XRCC6_HUMAN	XRCC6	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
ZHX1_HUMAN	ZHX1	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
MED31_HUMAN	MED31	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
G3P_HUMAN	GAPDH	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
P53_HUMAN	TP53	physical	16169070
TBB2A_HUMAN	TUBB2A	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
BRD7_HUMAN	BRD7	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
LIS1_HUMAN	PAFAH1B1	physical	10727864
HNRPD_HUMAN	HNRNPD	physical	22863883
LDHA_HUMAN	LDHA	physical	22863883
LDHB_HUMAN	LDHB	physical	22863883
PA1B2_HUMAN	PAFAH1B2	physical	22863883
PA1B3_HUMAN	PAFAH1B3	physical	25416956
LIS1_HUMAN	PAFAH1B1	physical	26186194
CN166_HUMAN	C14orf166	physical	26344197
SYVC_HUMAN	VARS	physical	26344197
PA1B3_HUMAN	PAFAH1B3	physical	21516116
LIS1_HUMAN	PAFAH1B1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.