TDRD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TDRD6_HUMAN
• UniProt AC: O60522
• Protein Name: Tudor domain-containing protein 6
• Gene Name: TDRD6
• Organism: Homo sapiens (Human).
• Sequence Length: 2096
• Subcellular Localization: Cytoplasm . Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic
• Protein Description: Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression..
• Protein Sequence: MCSTPGMPAPGASLALRVSFVDVHPDVIPVQLWGLVGERRGEYLRLSREIQEAAATRGQWALGSASASPGELCLVQVGLLWHRCRVVSRQAQESRVFLLDEGRTITAGAGSLAPGRREFFNLPSEVLGCVLAGLVPAGCGAGSGEPPQHWPADAVDFLSNLQGKEVHGCVLDVLLLHRLVLLEVPDVFQQMRELGLARRVPDSLFRSLLERYLTAATASVGSGVPVLSRVPLKQKQPGLDYFYPQLQLGVTEAVVITQVCHPHRIHCQLRSVSQEIHRLSESMAQVYRGSTGTGDENSTSATWEEREESPDKPGSPCASCGLDGHWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDGGRGWSRSQVGDLKTLILGKAVNAKIEFYCSFEHVYYVSLYGEDGINLNRVFGVQSCCLADRVLQSQATEEEEPETSQSQSPAEEVDEEISLPALRSIRLKMNAFYDAQVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDGVVLKPEPDDLCCVKWKENGYYRAIVTKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPLGKTWSQEAVSFFKKTVLHKELVIHILDKQDHQYVIEILDESRTGEENISKVIAQAGYAKYQEFETKENILVNAHSPGHVSNHFTTESNKIPFAKTGEGEQKAKRENKTTSVSKALSDTTVVTNGSTELVVQEKVKRASVYFPLMQNCLEIKPGSSSKGELEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNTLACLAKRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVGQNPFVWDVKAIQAFNEFIDNAWQKNLELKCTIFALASINEELFNIVDLLTPFQSACHFLVEKRLARPVKLQKPLESSVQLHSYFYSTHDMKIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTSPLNPGTLCLAKYTDGNWYRGIVIEKEPKKVFFVDFGNIYVVTSDDLLPIPSDAYDVLLLPMQAVRCSLSDIPDHIPEEVVVWFQETILDKSLKALVVAKDPDGTLIIELYGDNIQISASINKKLGLLSYKDRIRKKESEVLCSTTETLEEKNENMKLPCTEYLSKSVGYKLPNKEILEESYKPQINSSYKELKLLQSLTKTNLVTQYQDSVGNKNSQVFPLTTEKKEEISAETPLKTARVEATLSERKIGDSCDKDLPLKFCEFPQKTIMPGFKTTVYVSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVPDNKNSKKMMHYFSQRTSEAAIRCEFVKFQDRWEVILADEHGIIADDMISRYALSEKSQVELSTQVIKSASSKSVNKSDIDTSVFLNWYNPEKKMIRAYATVIDGPEYFWCQFADTEKLQCLEVEVQTAGEQVADRRNCIPCPYIGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEDCVDPKALWAIPSELLSVPMQAFPCCLSGFNISEGLCSQEGNDYFYEIITEDVLEITILEIRRDVCDIPLAIVDLKSKGKSINEKMEKYSKTGIKSALPYENIDSEIKQTLGSYNLDVGLKKLSNKAVQNKIYMEQQTDELAEITEKDVNIIGTKPSNFRDPKTDNICEGFENPCKDKIDTEELEGELECHLVDKAEFDDKYLITGFNTLLPHANETKEILELNSLEVPLSPDDESKEFLELESIELQNSLVVDEEKGELSPVPPNVPLSQECVTKGAMELFTLQLPLSCEAEKQPELELPTAQLPLDDKMDPLSLGVSQKAQESMCTEDMRKSSCVESFDDQRRMSLHLHGADCDPKTQNEMNICEEEFVEYKNRDAISALMPLFSEEESSDGSKHNNGLPDHISAQLQNTYTLKAFTVGSKCVVWSSLRNTWSKCEILETAEEGTRVLNLSNGMEEIVNPENVWNGIPKLDKSPPEKRGLEVMEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	VGERRGEYLRLSREI HCCHHHHHHHHHHHH	10.43	-
293	Phosphorylation	VYRGSTGTGDENSTS HHCCCCCCCCCCCCC	41.36	-
366	Phosphorylation	LRYLLPEYFRMPVVT HHHHCHHHHCCCEEC	8.44	-
373	Phosphorylation	YFRMPVVTYPCALYG HHCCCEECCCCCCCC	23.21	-
374	Phosphorylation	FRMPVVTYPCALYGL HCCCEECCCCCCCCC	5.68	-
389	Phosphorylation	WDGGRGWSRSQVGDL CCCCCCCCHHHCCCH	25.52	-
391	Phosphorylation	GGRGWSRSQVGDLKT CCCCCCHHHCCCHHH	24.57	-
403	Acetylation	LKTLILGKAVNAKIE HHHHHHCCHHHCEEE	45.79	91387
474	Phosphorylation	EEVDEEISLPALRSI HHCCHHCCHHHHHHH	31.42	24719451
552	Phosphorylation	VKWKENGYYRAIVTK EEECCCCEEEEEEEE	11.02	22461510
553	Phosphorylation	KWKENGYYRAIVTKL EECCCCEEEEEEEEC	8.58	22461510
611	Phosphorylation	DIWPLGKTWSQEAVS HHCCCCCCCCHHHHH	28.66	-
651	Phosphorylation	EILDESRTGEENISK EEEECCCCCHHHHHH	59.22	28509920
657	Phosphorylation	RTGEENISKVIAQAG CCCHHHHHHHHHHHC	32.24	28509920
665	Phosphorylation	KVIAQAGYAKYQEFE HHHHHHCCCCCCEEE	11.70	28509920
668	Phosphorylation	AQAGYAKYQEFETKE HHHCCCCCCEEECCC	12.71	28509920
673	Phosphorylation	AKYQEFETKENILVN CCCCEEECCCCEEEE	49.32	28509920
772	Phosphorylation	KGELEVGSTVEVRVS CCEEECCCEEEEEEE	34.16	26699800
773	Phosphorylation	GELEVGSTVEVRVSY CEEECCCEEEEEEEE	18.11	26699800
1136	Phosphorylation	VAKDPDGTLIIELYG EEECCCCCEEEEEEC	23.36	-
1142	Phosphorylation	GTLIIELYGDNIQIS CCEEEEEECCCEEEE	15.05	-
1161	Phosphorylation	KKLGLLSYKDRIRKK HHHCCCCHHHHHCHH	19.51	-
1170	Phosphorylation	DRIRKKESEVLCSTT HHHCHHHHHHEEECC	41.71	-
1175	Phosphorylation	KESEVLCSTTETLEE HHHHHEEECCHHHHH	33.91	-
1201	Phosphorylation	YLSKSVGYKLPNKEI HHHHHCCCCCCCHHH	13.75	26074081
1254	Phosphorylation	NSQVFPLTTEKKEEI CCEEEECCCCCCHHC	32.90	-
1255	Phosphorylation	SQVFPLTTEKKEEIS CEEEECCCCCCHHCC	54.19	-
1262	Phosphorylation	TEKKEEISAETPLKT CCCCHHCCCCCCCCC	24.27	26074081
1265	Phosphorylation	KEEISAETPLKTARV CHHCCCCCCCCCHHH	33.37	26074081
1269	Phosphorylation	SAETPLKTARVEATL CCCCCCCCHHHHHCC	27.64	26074081
1275	Phosphorylation	KTARVEATLSERKIG CCHHHHHCCCCCHHC	19.81	26074081
1277	Phosphorylation	ARVEATLSERKIGDS HHHHHCCCCCHHCCC	30.88	26074081
1300	Phosphorylation	FCEFPQKTIMPGFKT CCCCCCCCCCCCCEE	19.77	-
1310	Phosphorylation	PGFKTTVYVSHINDL CCCEEEEEEEEECHH	8.31	-
1340	Phosphorylation	HLSERLNSVKTRPEY HHHHHHHCCCCCCHH	29.58	24719451
1493	Acetylation	ELSTQVIKSASSKSV HHHHHHHHHCCCCCC	40.90	20167786
1599	Phosphorylation	ICEDYLVSVRLVDFG HCCCCCEEEEEEECC	10.02	24719451
1690	Phosphorylation	DLKSKGKSINEKMEK EHHHCCCCHHHHHHH	39.04	24719451
1694	Acetylation	KGKSINEKMEKYSKT CCCCHHHHHHHHHHC	48.12	19849175
1697	Acetylation	SINEKMEKYSKTGIK CHHHHHHHHHHCCHH	51.86	24431351
1698	Phosphorylation	INEKMEKYSKTGIKS HHHHHHHHHHCCHHH	11.33	24719451
1699	Phosphorylation	NEKMEKYSKTGIKSA HHHHHHHHHCCHHHC	34.51	24719451
1701	Phosphorylation	KMEKYSKTGIKSALP HHHHHHHCCHHHCCC	37.89	22210691
1722	Phosphorylation	EIKQTLGSYNLDVGL HHHHHHCCCCCCHHH	17.60	-
1723	Phosphorylation	IKQTLGSYNLDVGLK HHHHHCCCCCCHHHH	20.25	-
1853	Phosphorylation	KEFLELESIELQNSL HHHHEEEEEEEECCE	33.71	-
1898	Phosphorylation	FTLQLPLSCEAEKQP EEEECCCCCCCCCCC	14.15	25627689
2062	Phosphorylation	GTRVLNLSNGMEEIV CCEEEECCCCCEECC	30.20	-
2084	Phosphorylation	GIPKLDKSPPEKRGL CCCCCCCCCCHHCCC	45.41	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TDRD6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TDRD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TDRD6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TDRD6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.