| UniProt ID | MACD2_HUMAN | |
|---|---|---|
| UniProt AC | A1Z1Q3 | |
| Protein Name | O-acetyl-ADP-ribose deacetylase MACROD2 | |
| Gene Name | MACROD2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 448 | |
| Subcellular Localization | Nucleus. Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. | |
| Protein Description | Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.. | |
| Protein Sequence | MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQRNGTK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | LEERRKEYLRDYIPL HHHHHHHHHHHHCCH | 15.29 | 29759185 | |
| 34 | Phosphorylation | RKEYLRDYIPLNSIL HHHHHHHHCCHHHHH | 9.67 | 29759185 | |
| 39 | Phosphorylation | RDYIPLNSILSWKEE HHHCCHHHHHHHHHH | 32.37 | 29759185 | |
| 42 | Phosphorylation | IPLNSILSWKEEMKG CCHHHHHHHHHHHCC | 34.14 | 29759185 | |
| 170 | Ubiquitination | NCYKSSLKLVKENNI HHHHHHHHHHHHCCC | 53.86 | 18655026 | |
| 191 | Phosphorylation | CISTGIYGFPNEPAA EECCCCCCCCCCCHH | 29.61 | 27251275 | |
| 258 | Phosphorylation | DVEMKEDSDENGPEE HHCCCCCCCCCCHHH | 48.17 | 25849741 | |
| 426 | Phosphorylation | KVNDPTESQQEDQLI CCCCCCHHHHHHHHH | 39.37 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MACD2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MACD2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MACD2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MACD2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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