PCMD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCMD2_HUMAN
• UniProt AC: Q9NV79
• Protein Name: Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
• Gene Name: PCMTD2
• Organism: Homo sapiens (Human).
• Sequence Length: 361
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKENAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVIEYAKQKLDFFIRTSDSFDKFDFCEPSFVTGNCLEISPDCSQYDRVYCGAGVQKEHEEYMKNLLKVGGILVMPLEEKLTKITRTGPSAWETKKILAVSFAPLIQPCHSESGKSRLVQLPPVAVRSLQDLARIAIRGTIKKIIHQETVSKNGNGLKNTPRFKRRRVRRRRMETIVFLDKEVFASRISNPSDDNSCEDLEEERREEEEKTPPETKPDPPVNFLRQKVLSLPLPDPLKYYLLYYREK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGGAVSAGE ------CCCCCCCCC	32.54	-
6	Phosphorylation	--MGGAVSAGEDNDE --CCCCCCCCCCCHH	29.98	21722762
47	Ubiquitination	DYYLEEFKENAYKDL HHHHHHHHHHHHHHH	54.03	22817900
47 (in isoform 2)	Ubiquitination	-	54.03	21890473
47 (in isoform 1)	Ubiquitination	-	54.03	21890473
52	Ubiquitination	EFKENAYKDLAWKHG HHHHHHHHHHHHHCC	43.80	22817900
71 (in isoform 3)	Ubiquitination	-	28.98	21890473
122	Ubiquitination	SDVIEYAKQKLDFFI HHHHHHHHHHHCEEE	47.25	22817900
124	Ubiquitination	VIEYAKQKLDFFIRT HHHHHHHHHCEEEEC	49.68	21890473
124 (in isoform 2)	Ubiquitination	-	49.68	21890473
124 (in isoform 1)	Ubiquitination	-	49.68	21890473
134	Phosphorylation	FFIRTSDSFDKFDFC EEEECCCCCCCCCCC	34.80	25627689
171	Ubiquitination	YCGAGVQKEHEEYMK ECCCCCHHHHHHHHH	59.64	29967540
182	Ubiquitination	EYMKNLLKVGGILVM HHHHHHHHHCCEEEE	41.84	-
194	Ubiquitination	LVMPLEEKLTKITRT EEEEHHHHHHHHHCC	52.67	22817900
194 (in isoform 1)	Ubiquitination	-	52.67	21890473
197	Ubiquitination	PLEEKLTKITRTGPS EHHHHHHHHHCCCCC	53.14	22817900
229	Ubiquitination	PCHSESGKSRLVQLP CCCCCCCCCCEECCC	41.50	-
229	Acetylation	PCHSESGKSRLVQLP CCCCCCCCCCEECCC	41.50	25953088
230	Ubiquitination	CHSESGKSRLVQLPP CCCCCCCCCEECCCH	34.08	29967540
257	Ubiquitination	AIRGTIKKIIHQETV HHHHHHHHHHCHHHH	42.94	29967540
263	Phosphorylation	KKIIHQETVSKNGNG HHHHCHHHHCCCCCC	24.41	22673903
265	Phosphorylation	IIHQETVSKNGNGLK HHCHHHHCCCCCCCC	28.02	22673903
268	Ubiquitination	QETVSKNGNGLKNTP HHHHCCCCCCCCCCH	33.06	33845483
268 (in isoform 2)	Ubiquitination	-	33.06	21890473
274	Phosphorylation	NGNGLKNTPRFKRRR CCCCCCCCHHHHHHH	17.79	25849741
295	Ubiquitination	ETIVFLDKEVFASRI EEEEEECHHHHHHHC	58.90	22817900
295 (in isoform 1)	Ubiquitination	-	58.90	21890473
303	Phosphorylation	EVFASRISNPSDDNS HHHHHHCCCCCCCCC	41.39	25850435
306	Phosphorylation	ASRISNPSDDNSCED HHHCCCCCCCCCCHH	62.94	25849741
310	Phosphorylation	SNPSDDNSCEDLEEE CCCCCCCCCHHHHHH	26.36	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCMD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCMD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCMD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL5_HUMAN	CUL5	physical	18187417
ELOB_HUMAN	TCEB2	physical	18187417
ELOC_HUMAN	TCEB1	physical	18187417
CUL2_HUMAN	CUL2	physical	18187417
VAC14_HUMAN	VAC14	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.