ZMIZ1_HUMAN - dbPTM
ZMIZ1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZMIZ1_HUMAN
UniProt AC Q9ULJ6
Protein Name Zinc finger MIZ domain-containing protein 1
Gene Name ZMIZ1
Organism Homo sapiens (Human).
Sequence Length 1067
Subcellular Localization Nucleus speckle . Cytoplasm .
Protein Description Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. [PubMed: 14609956]
Protein Sequence MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPAQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQNIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPAPNPPRPLTSPNYPGQRMPSQPSSGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPPPPSQPPRQPPQAAPSSHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
91SumoylationNRDKFTPKSAALLSS
CCCCCCHHHHHHHHH		50.0628112733
91UbiquitinationNRDKFTPKSAALLSS
CCCCCCHHHHHHHHH		50.06-
98PhosphorylationKSAALLSSWCEELGR
HHHHHHHHHHHHHHH		35.4027762562
341PhosphorylationPGPRGPASMGGSMNP
CCCCCCCCCCCCCCH		22.5422210691
345PhosphorylationGPASMGGSMNPASMA
CCCCCCCCCCHHHHH		15.0622210691
394MethylationQQTYPGPRPQSLPIQ
CCCCCCCCCCCCCCC		48.05115490201
404MethylationSLPIQNIKRPYPGEP
CCCCCCCCCCCCCCC		55.67115490207
404SumoylationSLPIQNIKRPYPGEP
CCCCCCCCCCCCCCC		55.67-
438DimethylationYPAPNPPRPLTSPNY
CCCCCCCCCCCCCCC		39.87-
438MethylationYPAPNPPRPLTSPNY
CCCCCCCCCCCCCCC		39.8752719469
452PhosphorylationYPGQRMPSQPSSGQY
CCCCCCCCCCCCCCC		45.4323663014
455PhosphorylationQRMPSQPSSGQYPPP
CCCCCCCCCCCCCCC		39.1923663014
456PhosphorylationRMPSQPSSGQYPPPT
CCCCCCCCCCCCCCC		36.2822210691
459PhosphorylationSQPSSGQYPPPTVNM
CCCCCCCCCCCCCCC		22.6423663014
463PhosphorylationSGQYPPPTVNMGQYY
CCCCCCCCCCCCCCC		30.2222210691
469PhosphorylationPTVNMGQYYKPEQFN
CCCCCCCCCCHHHHC		14.0223663014
470PhosphorylationTVNMGQYYKPEQFNG
CCCCCCCCCHHHHCC		16.5123663014
531PhosphorylationSSIPPYLSPSQDVKP
CCCCCCCCCCCCCCC		19.3626657352
533PhosphorylationIPPYLSPSQDVKPPF
CCCCCCCCCCCCCCC		35.3228176443
541 (in isoform 2)Ubiquitination-31.2821890473
611UbiquitinationSDLELQFKCYHHEDR
CCEEEEEEEEECCCC		22.4121890473
611 (in isoform 1)Ubiquitination-22.4121890473
645UbiquitinationTIERGDNKTSHKPLH
EEECCCCCCCCCCEE		57.03-
696SumoylationSVLQGLLKKRLLPAE
HHHHHHHHHCCCCHH		40.67-
696SumoylationSVLQGLLKKRLLPAE
HHHHHHHHHCCCCHH		40.67-
719PhosphorylationNFSSVAASSGNTTLN
HHHHHHHCCCCCEEC		29.1022210691
723PhosphorylationVAASSGNTTLNGEDG
HHHCCCCCEECCCCC		35.8630576142
724PhosphorylationAASSGNTTLNGEDGV
HHCCCCCEECCCCCC		23.4022210691
834SumoylationIKSDLHIKDDPDGIP
CCCCCEECCCCCCCC		45.38-
834SumoylationIKSDLHIKDDPDGIP
CCCCCEECCCCCCCC		45.3828112733
842PhosphorylationDDPDGIPSKRFKTMS
CCCCCCCCHHCCCCC		34.2424719451
843SumoylationDPDGIPSKRFKTMSP
CCCCCCCHHCCCCCH		57.4028112733
843AcetylationDPDGIPSKRFKTMSP
CCCCCCCHHCCCCCH		57.4023236377
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZMIZ1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZMIZ1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZMIZ1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANDR_HUMANARphysical
14609956
P53_HUMANTP53physical
17584785
PIAS3_HUMANPIAS3physical
20159969
SMAD3_HUMANSMAD3physical
16777850
SMAD4_HUMANSMAD4physical
16777850
SETD4_HUMANSETD4physical
26344197
MAML1_HUMANMAML1physical
26522984
SUH_HUMANRBPJphysical
26522984
NOTC1_HUMANNOTCH1physical
26522984
TIF1B_HUMANTRIM28physical
26522984
SATB1_HUMANSATB1physical
26522984
NFAC3_HUMANNFATC3physical
26522984
CTNB1_HUMANCTNNB1physical
26522984
ZEB1_HUMANZEB1physical
26522984
CCR7_HUMANCCR7physical
26522984
BRCA1_HUMANBRCA1physical
26522984
BCLF1_HUMANBCLAF1physical
26522984
TCF7_HUMANTCF7physical
26522984
SIR1_HUMANSIRT1physical
26522984
ETS1_HUMANETS1physical
26522984
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZMIZ1_HUMAN

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Related Literatures of Post-Translational Modification

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