| UniProt ID | SETD4_HUMAN | |
|---|---|---|
| UniProt AC | Q9NVD3 | |
| Protein Name | SET domain-containing protein 4 | |
| Gene Name | SETD4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 440 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MQKGKGRTSRIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGRGLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLALCTFLVSEKHAGHRSLWKPYLEILPKAYTCPVCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSLQPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHSPHVQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHACVYVSREILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRLLTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKICYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELKILRASAETLHSLQTAFT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Ubiquitination | RGVNESHKSEFIELR CCCCHHHHHHHHHHH | 62.04 | - | |
| 44 | Ubiquitination | RKWLKARKFQDSNLA HHHHHHHCCCCCCCC | 52.84 | - | |
| 103 (in isoform 3) | Ubiquitination | - | 37.97 | 21890473 | |
| 127 | Ubiquitination | AGHRSLWKPYLEILP CCCCHHCHHHHHHCC | 29.13 | 21890473 | |
| 127 (in isoform 1) | Ubiquitination | - | 29.13 | 21890473 | |
| 231 | Phosphorylation | DTCALAPYLDLLNHS CCCCHHHHHHHHHCC | 13.77 | - | |
| 319 | Phosphorylation | KQMDKKISILKDHGY CHHHHHHHHHHHCCC | 30.65 | 24719451 | |
| 326 | Phosphorylation | SILKDHGYIENLTFG HHHHHCCCEECCCCC | 11.14 | 30206219 | |
| 331 | Phosphorylation | HGYIENLTFGWDGPS CCCEECCCCCCCCHH | 31.51 | 30206219 | |
| 338 | Phosphorylation | TFGWDGPSWRLLTAL CCCCCCHHHHHHHHH | 30.29 | 30206219 | |
| 428 | Phosphorylation | ELKILRASAETLHSL HHHHHHHHHHHHHHH | 21.87 | 25278378 | |
| 431 | Phosphorylation | ILRASAETLHSLQTA HHHHHHHHHHHHHHC | 29.50 | 25278378 | |
| 434 | Phosphorylation | ASAETLHSLQTAFT- HHHHHHHHHHHCCC- | 25.86 | 25278378 | |
| 437 | Phosphorylation | ETLHSLQTAFT---- HHHHHHHHCCC---- | 29.09 | 25278378 | |
| 440 | Phosphorylation | HSLQTAFT------- HHHHHCCC------- | 34.93 | 25278378 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SETD4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SETD4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SETD4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GLGB_HUMAN | GBE1 | physical | 26496610 | |
| GDF15_HUMAN | GDF15 | physical | 26496610 | |
| TADA3_HUMAN | TADA3 | physical | 26496610 | |
| WWP1_HUMAN | WWP1 | physical | 26496610 | |
| LRC59_HUMAN | LRRC59 | physical | 26496610 | |
| CORO7_HUMAN | CORO7 | physical | 26496610 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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