CCR7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCR7_HUMAN
• UniProt AC: P32248
• Protein Name: C-C chemokine receptor type 7
• Gene Name: CCR7
• Organism: Homo sapiens (Human).
• Sequence Length: 378
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions..
• Protein Sequence: MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	N-linked_Glycosylation	TDDYIGDNTTVDYTL CCCCCCCCCEECHHH	32.22	UniProtKB CARBOHYD
37	O-linked_Glycosylation	DDYIGDNTTVDYTLF CCCCCCCCEECHHHH	32.70	OGP
38	O-linked_Glycosylation	DYIGDNTTVDYTLFE CCCCCCCEECHHHHH	20.03	OGP
42	O-linked_Glycosylation	DNTTVDYTLFESLCS CCCEECHHHHHHHHC	22.10	OGP
65	Phosphorylation	AWFLPIMYSIICFVG HHHHHHHHHHHHHHH	9.46	-
66	Phosphorylation	WFLPIMYSIICFVGL HHHHHHHHHHHHHHH	6.52	-
151	Phosphorylation	MLLLLCISIDRYVAI HHHHHHHHHHHHHHH	19.89	22817900
155	Phosphorylation	LCISIDRYVAIVQAV HHHHHHHHHHHHHHH	7.18	-
202	Phosphorylation	LYSDLQRSSSEQAMR HHHHHCCCCHHHHHH	25.84	24719451
342	Ubiquitination	NDLFKLFKDLGCLSQ HHHHHHHHHHCCCCH	63.58	-
356	Phosphorylation	QEQLRQWSSCRHIRR HHHHHHHHHCHHHHH	15.95	15054093
357	Phosphorylation	EQLRQWSSCRHIRRS HHHHHHHHCHHHHHH	16.53	15054093
364	Phosphorylation	SCRHIRRSSMSVEAE HCHHHHHHCCCEEEE	22.12	30108239
365	Phosphorylation	CRHIRRSSMSVEAET CHHHHHHCCCEEEEE	17.17	30108239
367	Phosphorylation	HIRRSSMSVEAETTT HHHHHCCCEEEEEEC	20.82	27080861
372	Phosphorylation	SMSVEAETTTTFSP- CCCEEEEEECCCCC-	36.17	15054093
373	Phosphorylation	MSVEAETTTTFSP-- CCEEEEEECCCCC--	18.49	15054093
374	Phosphorylation	SVEAETTTTFSP--- CEEEEEECCCCC---	33.01	15054093
375	Phosphorylation	VEAETTTTFSP---- EEEEEECCCCC----	21.74	15054093
377	Phosphorylation	AETTTTFSP------ EEEECCCCC------	27.84	15054093

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
155	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCR7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCR7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCL19_HUMAN	CCL19	physical	9153236

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND MASSSPECTROMETRY.
PubMed: 18187866