| UniProt ID | TCF7_HUMAN | |
|---|---|---|
| UniProt AC | P36402 | |
| Protein Name | Transcription factor 7 | |
| Gene Name | TCF7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 384 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.. | |
| Protein Sequence | MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESEGAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNSPHPTPAPADISQKQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTETNWPRELKDGNGQESLSMSSSSSPA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MPQLDSGGGGAGG --CCCCCCCCCCCCC | 48.18 | 28634120 | |
| 36 | Ubiquitination | EGEEQDDKSRDSAAG CCCCCCHHHCCCCCC | 56.53 | - | |
| 36 (in isoform 9) | Ubiquitination | - | 56.53 | - | |
| 37 | Phosphorylation | GEEQDDKSRDSAAGP CCCCCHHHCCCCCCC | 48.60 | 30108239 | |
| 40 | Phosphorylation | QDDKSRDSAAGPERD CCHHHCCCCCCCHHH | 20.93 | 30108239 | |
| 52 | Ubiquitination | ERDLAELKSSLVNES HHHHHHHHHHHHCCC | 29.51 | - | |
| 52 (in isoform 5) | Ubiquitination | - | 29.51 | - | |
| 52 (in isoform 9) | Ubiquitination | - | 29.51 | - | |
| 98 (in isoform 9) | Ubiquitination | - | 67.20 | - | |
| 98 | Ubiquitination | AQRLFPDKLPEPLED HHHHCCCCCCCCCCC | 67.20 | - | |
| 108 (in isoform 9) | Ubiquitination | - | 68.38 | - | |
| 108 | Ubiquitination | EPLEDGLKAPECTSG CCCCCCCCCCCCCCC | 68.38 | - | |
| 117 | Phosphorylation | PECTSGMYKETVYSA CCCCCCHHHHHHHHH | 14.81 | - | |
| 161 | Phosphorylation | PHGVPQLSLYEHFNS CCCCCCCCHHHCCCC | 24.53 | 28796482 | |
| 163 | Phosphorylation | GVPQLSLYEHFNSPH CCCCCCHHHCCCCCC | 12.18 | 28796482 | |
| 168 | Phosphorylation | SLYEHFNSPHPTPAP CHHHCCCCCCCCCCC | 24.52 | 28796482 | |
| 172 | Phosphorylation | HFNSPHPTPAPADIS CCCCCCCCCCCCCCC | 29.11 | 28796482 | |
| 179 | Phosphorylation | TPAPADISQKQVHRP CCCCCCCCHHCCCCC | 31.69 | - | |
| 181 | Ubiquitination | APADISQKQVHRPLQ CCCCCCHHCCCCCCC | 47.71 | - | |
| 234 (in isoform 12) | Phosphorylation | - | 20.51 | 26657352 | |
| 234 (in isoform 4) | Phosphorylation | - | 20.51 | 26657352 | |
| 234 (in isoform 8) | Phosphorylation | - | 20.51 | 26657352 | |
| 237 (in isoform 10) | Ubiquitination | - | 6.57 | - | |
| 241 (in isoform 4) | Phosphorylation | - | 41.25 | 29978859 | |
| 241 (in isoform 8) | Phosphorylation | - | 41.25 | 29978859 | |
| 241 (in isoform 12) | Phosphorylation | - | 41.25 | 29978859 | |
| 242 (in isoform 4) | Phosphorylation | - | 44.96 | 29978859 | |
| 242 (in isoform 8) | Phosphorylation | - | 44.96 | 29978859 | |
| 242 (in isoform 12) | Phosphorylation | - | 44.96 | 29978859 | |
| 243 (in isoform 4) | Phosphorylation | - | 61.22 | 26657352 | |
| 243 (in isoform 8) | Phosphorylation | - | 61.22 | 26657352 | |
| 243 (in isoform 12) | Phosphorylation | - | 61.22 | 26657352 | |
| 247 (in isoform 4) | Phosphorylation | - | 45.81 | 26657352 | |
| 247 (in isoform 8) | Phosphorylation | - | 45.81 | 26657352 | |
| 247 (in isoform 12) | Phosphorylation | - | 45.81 | 26657352 | |
| 250 (in isoform 10) | Phosphorylation | - | 51.24 | - | |
| 253 | Ubiquitination | QPFDRNLKTQAESKA CCCCHHHHHHHHHHH | 41.98 | - | |
| 253 | Acetylation | QPFDRNLKTQAESKA CCCCHHHHHHHHHHH | 41.98 | 25953088 | |
| 253 (in isoform 9) | Ubiquitination | - | 41.98 | - | |
| 259 | Ubiquitination | LKTQAESKAEKEAKK HHHHHHHHHHHHHCC | 52.66 | - | |
| 259 (in isoform 9) | Ubiquitination | - | 52.66 | - | |
| 271 | Ubiquitination | AKKPTIKKPLNAFML HCCCCCCHHHHHHHH | 51.38 | - | |
| 271 (in isoform 5) | Ubiquitination | - | 51.38 | - | |
| 281 | Ubiquitination | NAFMLYMKEMRAKVI HHHHHHHHHHHHHHH | 34.50 | - | |
| 286 (in isoform 9) | Ubiquitination | - | 24.65 | - | |
| 286 | Ubiquitination | YMKEMRAKVIAECTL HHHHHHHHHHHHCCC | 24.65 | - | |
| 294 (in isoform 9) | Ubiquitination | - | 31.31 | - | |
| 294 | Ubiquitination | VIAECTLKESAAINQ HHHHCCCCHHHHHHH | 31.31 | - | |
| 317 | Ubiquitination | LSREEQAKYYELARK CCHHHHHHHHHHHHH | 48.32 | - | |
| 317 (in isoform 5) | Ubiquitination | - | 48.32 | - | |
| 318 | Phosphorylation | SREEQAKYYELARKE CHHHHHHHHHHHHHH | 12.75 | - | |
| 319 | Phosphorylation | REEQAKYYELARKER HHHHHHHHHHHHHHH | 12.08 | - | |
| 333 | Phosphorylation | RQLHMQLYPGWSARD HHHHHHHCCCCHHHC | 5.25 | - | |
| 337 | Phosphorylation | MQLYPGWSARDNYGK HHHCCCCHHHCCCCH | 21.24 | - | |
| 349 (in isoform 7) | Phosphorylation | - | 49.15 | 26657352 | |
| 349 (in isoform 11) | Phosphorylation | - | 49.15 | 26657352 | |
| 349 (in isoform 3) | Phosphorylation | - | 49.15 | 26657352 | |
| 352 (in isoform 9) | Ubiquitination | - | 49.86 | - | |
| 356 (in isoform 11) | Phosphorylation | - | 33.78 | 29978859 | |
| 356 (in isoform 3) | Phosphorylation | - | 33.78 | 29978859 | |
| 356 (in isoform 7) | Phosphorylation | - | 33.78 | 29978859 | |
| 357 (in isoform 3) | Phosphorylation | - | 28.09 | 29978859 | |
| 357 (in isoform 7) | Phosphorylation | - | 28.09 | 29978859 | |
| 357 (in isoform 11) | Phosphorylation | - | 28.09 | 29978859 | |
| 358 (in isoform 11) | Phosphorylation | - | 50.52 | 26657352 | |
| 358 (in isoform 7) | Phosphorylation | - | 50.52 | 26657352 | |
| 358 (in isoform 3) | Phosphorylation | - | 50.52 | 26657352 | |
| 362 (in isoform 3) | Phosphorylation | - | 10.76 | 26657352 | |
| 362 (in isoform 7) | Phosphorylation | - | 10.76 | 26657352 | |
| 362 (in isoform 11) | Phosphorylation | - | 10.76 | 26657352 | |
| 365 (in isoform 9) | Phosphorylation | - | 56.97 | - | |
| 371 (in isoform 5) | Ubiquitination | - | 37.86 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCF7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCF7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCF7_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DAZP2_HUMAN | DAZAP2 | physical | 19304756 | |
| CREST_HUMAN | SS18L1 | physical | 20211142 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
