PDE6A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE6A_HUMAN
• UniProt AC: P16499
• Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
• Gene Name: PDE6A
• Organism: Homo sapiens (Human).
• Sequence Length: 860
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: This protein participates in processes of transmission and amplification of the visual signal..
• Protein Sequence: MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEIIFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGNQPGGNPSPGGATTSKSCCIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGEVTAEEV ------CCCCCHHHH	37.77	-
5	Phosphorylation	---MGEVTAEEVEKF ---CCCCCHHHHHHH	24.85	29978859
15	Phosphorylation	EVEKFLDSNIGFAKQ HHHHHHHCCCHHHHH	32.28	24719451
23	Phosphorylation	NIGFAKQYYNLHYRA CCHHHHHHHCHHHHH	8.13	29978859
24	Phosphorylation	IGFAKQYYNLHYRAK CHHHHHHHCHHHHHH	14.57	29978859
28	Phosphorylation	KQYYNLHYRAKLISD HHHHCHHHHHHHHHH	18.55	29978859
84	"N6,N6-dimethyllysine"	CIFNVMKKLCFLLQA HHHHHHHHHHHHHHH	32.18	-
84	Methylation	CIFNVMKKLCFLLQA HHHHHHHHHHHHHHH	32.18	23644510
180	Phosphorylation	KTKNILASPIMNGKD CCCCCCCCCCCCCCC	16.12	25332170
264	Phosphorylation	RQFHKALYTVRAFLN HHHHHHHHHHHHHHC	14.19	-
275	Phosphorylation	AFLNCDRYSVGLLDM HHHCCCCEEEECCCC	8.41	-
283	Phosphorylation	SVGLLDMTKQKEFFD EEECCCCCCCHHHHH	29.95	-
402	Phosphorylation	EEIVGVATFYNRKDG CEEEEEEEEEECCCC	25.01	29083192
467	Acetylation	CDNEEIQKILKTREV CCHHHHHHHHHHCCH	56.52	178226441
677	Acetylation	DLALYFKKRTMFQKI HHHHHHHHHHHHHHH	43.11	19811551
717	Phosphorylation	IVMAMMMTACDLSAI HHHHHHHHHCCHHHC	13.26	-
847	O-linked_Glycosylation	NQPGGNPSPGGATTS CCCCCCCCCCCCCCC	39.93	OGP
857	Farnesylation	GATTSKSCCIQ---- CCCCCCCCCCC----	2.45	-
857	Methylation	GATTSKSCCIQ---- CCCCCCCCCCC----	2.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDE6A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE6A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE6A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PDE6A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.