| UniProt ID | ZN467_HUMAN | |
|---|---|---|
| UniProt AC | Q7Z7K2 | |
| Protein Name | Zinc finger protein 467 | |
| Gene Name | ZNF467 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 595 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).. | |
| Protein Sequence | MRETLEALSSLGFSVGQPEMAPQSEPREGSHNAQEQMSSSREERALGVCSGHEAPTPEEGAHTEQAEAPCRGQACSAQKAQPVGTCPGEEWMIRKVKVEDEDQEAEEEVEWPQHLSLLPSPFPAPDLGHLAAAYKLEPGAPGALSGLALSGWGPMPEKPYGCGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPCSECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTHKQHLVRHQRVHQTAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFGWKKNLATHQCLHRSEGRPFGCDECALGATVDAPAAKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVHTGSRPHACAVCARSFSSKTNLVRHQAIHTGSRPFSCPQCGKSFSRKTHLVRHQLIHGEAAHAAPDAALAAPAWSAPPEVAPPPLFF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | RETLEALSSLGFSVG HHHHHHHHHCCCCCC | 30.48 | 22210691 | |
| 38 | Phosphorylation | HNAQEQMSSSREERA CCHHHHHHHCHHHHH | 25.51 | 28348404 | |
| 39 | Phosphorylation | NAQEQMSSSREERAL CHHHHHHHCHHHHHH | 28.24 | 22210691 | |
| 40 | Phosphorylation | AQEQMSSSREERALG HHHHHHHCHHHHHHH | 36.08 | 22210691 | |
| 56 | Phosphorylation | CSGHEAPTPEEGAHT CCCCCCCCCCCCCCC | 50.83 | 28348404 | |
| 97 | Sumoylation | EWMIRKVKVEDEDQE CCEEEEEECCCCCHH | 42.83 | 28112733 | |
| 196 | Phosphorylation | ACPDCGRSFTQRAHM CCCCCCCCHHHHHHH | 20.23 | - | |
| 198 | Phosphorylation | PDCGRSFTQRAHMLL CCCCCCHHHHHHHHH | 20.56 | - | |
| 295 | Phosphorylation | IRHQRIHTGERPYQC HCCCCCCCCCCCCHH | 38.06 | - | |
| 368 | Sumoylation | GLSFGWKKNLATHQC CCCCCHHHCCCHHHH | 51.16 | 28112733 | |
| 470 | Phosphorylation | QCDRRFGSRPNLVAH CCHHCCCCCCCHHHC | 41.68 | 24719451 | |
| 482 | Phosphorylation | VAHSRAHSGARPFAC HHCCCCCCCCCCCCH | 32.91 | 24719451 | |
| 551 | Phosphorylation | SCPQCGKSFSRKTHL CCCCCCCCCCCCHHH | 17.46 | 17081983 | |
| 553 | Phosphorylation | PQCGKSFSRKTHLVR CCCCCCCCCCHHHHH | 39.70 | 17081983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZN467_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZN467_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZN467_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ZN467_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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