UniProt ID | ZN467_HUMAN | |
---|---|---|
UniProt AC | Q7Z7K2 | |
Protein Name | Zinc finger protein 467 | |
Gene Name | ZNF467 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 595 | |
Subcellular Localization | Nucleus. | |
Protein Description | Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).. | |
Protein Sequence | MRETLEALSSLGFSVGQPEMAPQSEPREGSHNAQEQMSSSREERALGVCSGHEAPTPEEGAHTEQAEAPCRGQACSAQKAQPVGTCPGEEWMIRKVKVEDEDQEAEEEVEWPQHLSLLPSPFPAPDLGHLAAAYKLEPGAPGALSGLALSGWGPMPEKPYGCGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPCSECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTHKQHLVRHQRVHQTAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFGWKKNLATHQCLHRSEGRPFGCDECALGATVDAPAAKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVHTGSRPHACAVCARSFSSKTNLVRHQAIHTGSRPFSCPQCGKSFSRKTHLVRHQLIHGEAAHAAPDAALAAPAWSAPPEVAPPPLFF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
9 | Phosphorylation | RETLEALSSLGFSVG HHHHHHHHHCCCCCC | 30.48 | 22210691 | |
38 | Phosphorylation | HNAQEQMSSSREERA CCHHHHHHHCHHHHH | 25.51 | 28348404 | |
39 | Phosphorylation | NAQEQMSSSREERAL CHHHHHHHCHHHHHH | 28.24 | 22210691 | |
40 | Phosphorylation | AQEQMSSSREERALG HHHHHHHCHHHHHHH | 36.08 | 22210691 | |
56 | Phosphorylation | CSGHEAPTPEEGAHT CCCCCCCCCCCCCCC | 50.83 | 28348404 | |
97 | Sumoylation | EWMIRKVKVEDEDQE CCEEEEEECCCCCHH | 42.83 | 28112733 | |
196 | Phosphorylation | ACPDCGRSFTQRAHM CCCCCCCCHHHHHHH | 20.23 | - | |
198 | Phosphorylation | PDCGRSFTQRAHMLL CCCCCCHHHHHHHHH | 20.56 | - | |
295 | Phosphorylation | IRHQRIHTGERPYQC HCCCCCCCCCCCCHH | 38.06 | - | |
368 | Sumoylation | GLSFGWKKNLATHQC CCCCCHHHCCCHHHH | 51.16 | 28112733 | |
470 | Phosphorylation | QCDRRFGSRPNLVAH CCHHCCCCCCCHHHC | 41.68 | 24719451 | |
482 | Phosphorylation | VAHSRAHSGARPFAC HHCCCCCCCCCCCCH | 32.91 | 24719451 | |
551 | Phosphorylation | SCPQCGKSFSRKTHL CCCCCCCCCCCCHHH | 17.46 | 17081983 | |
553 | Phosphorylation | PQCGKSFSRKTHLVR CCCCCCCCCCHHHHH | 39.70 | 17081983 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZN467_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZN467_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZN467_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of ZN467_HUMAN !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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