ZN467_HUMAN - dbPTM
ZN467_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN467_HUMAN
UniProt AC Q7Z7K2
Protein Name Zinc finger protein 467
Gene Name ZNF467
Organism Homo sapiens (Human).
Sequence Length 595
Subcellular Localization Nucleus.
Protein Description Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity)..
Protein Sequence MRETLEALSSLGFSVGQPEMAPQSEPREGSHNAQEQMSSSREERALGVCSGHEAPTPEEGAHTEQAEAPCRGQACSAQKAQPVGTCPGEEWMIRKVKVEDEDQEAEEEVEWPQHLSLLPSPFPAPDLGHLAAAYKLEPGAPGALSGLALSGWGPMPEKPYGCGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPCSECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTHKQHLVRHQRVHQTAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFGWKKNLATHQCLHRSEGRPFGCDECALGATVDAPAAKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVHTGSRPHACAVCARSFSSKTNLVRHQAIHTGSRPFSCPQCGKSFSRKTHLVRHQLIHGEAAHAAPDAALAAPAWSAPPEVAPPPLFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationRETLEALSSLGFSVG
HHHHHHHHHCCCCCC
30.4822210691
38PhosphorylationHNAQEQMSSSREERA
CCHHHHHHHCHHHHH
25.5128348404
39PhosphorylationNAQEQMSSSREERAL
CHHHHHHHCHHHHHH
28.2422210691
40PhosphorylationAQEQMSSSREERALG
HHHHHHHCHHHHHHH
36.0822210691
56PhosphorylationCSGHEAPTPEEGAHT
CCCCCCCCCCCCCCC
50.8328348404
97SumoylationEWMIRKVKVEDEDQE
CCEEEEEECCCCCHH
42.8328112733
196PhosphorylationACPDCGRSFTQRAHM
CCCCCCCCHHHHHHH
20.23-
198PhosphorylationPDCGRSFTQRAHMLL
CCCCCCHHHHHHHHH
20.56-
295PhosphorylationIRHQRIHTGERPYQC
HCCCCCCCCCCCCHH
38.06-
368SumoylationGLSFGWKKNLATHQC
CCCCCHHHCCCHHHH
51.1628112733
470PhosphorylationQCDRRFGSRPNLVAH
CCHHCCCCCCCHHHC
41.6824719451
482PhosphorylationVAHSRAHSGARPFAC
HHCCCCCCCCCCCCH
32.9124719451
551PhosphorylationSCPQCGKSFSRKTHL
CCCCCCCCCCCCHHH
17.4617081983
553PhosphorylationPQCGKSFSRKTHLVR
CCCCCCCCCCHHHHH
39.7017081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN467_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN467_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN467_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN467_HUMAN !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN467_HUMAN

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Related Literatures of Post-Translational Modification

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