CLIP1_HUMAN - dbPTM
CLIP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLIP1_HUMAN
UniProt AC P30622
Protein Name CAP-Gly domain-containing linker protein 1
Gene Name CLIP1
Organism Homo sapiens (Human).
Sequence Length 1438
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side. Cell projection, ruffle . Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends
Protein Description Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking..
Protein Sequence MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSMLKPSGL
------CCCCCCCCC		44.0920068231
2 (in isoform 1)Phosphorylation-44.09-
2 (in isoform 2)Phosphorylation-44.09-
7Phosphorylation-MSMLKPSGLKAPTK
-CCCCCCCCCCCCCC		55.9920068231
7 (in isoform 1)Phosphorylation-55.99-
7 (in isoform 2)Phosphorylation-55.99-
13PhosphorylationPSGLKAPTKILKPGS
CCCCCCCCCCCCCCC		35.26-
13 (in isoform 2)Phosphorylation-35.26-
14AcetylationSGLKAPTKILKPGST
CCCCCCCCCCCCCCC		45.0126051181
17AcetylationKAPTKILKPGSTALK
CCCCCCCCCCCCCCC		51.2925953088
20O-linked_GlycosylationTKILKPGSTALKTPT
CCCCCCCCCCCCCCC		21.0230059200
20PhosphorylationTKILKPGSTALKTPT
CCCCCCCCCCCCCCC		21.0220068231
21PhosphorylationKILKPGSTALKTPTA
CCCCCCCCCCCCCCE		41.7620068231
21 (in isoform 1)Phosphorylation-41.7624719451
24AcetylationKPGSTALKTPTAVVA
CCCCCCCCCCCEEEE		50.4226051181
25PhosphorylationPGSTALKTPTAVVAP
CCCCCCCCCCEEEEC		27.0725159151
25 (in isoform 1)Phosphorylation-27.07-
25 (in isoform 2)Phosphorylation-27.07-
27PhosphorylationSTALKTPTAVVAPVE
CCCCCCCCEEEECCE		37.0022199227
27 (in isoform 2)Phosphorylation-37.00-
35AcetylationAVVAPVEKTISSEKA
EEEECCEECCCCCCC		51.9325953088
36O-linked_GlycosylationVVAPVEKTISSEKAS
EEECCEECCCCCCCC		16.7630059200
36PhosphorylationVVAPVEKTISSEKAS
EEECCEECCCCCCCC		16.76-
36 (in isoform 2)Phosphorylation-16.76-
43PhosphorylationTISSEKASSTPSSET
CCCCCCCCCCCCCHH		45.9020044836
43 (in isoform 1)Phosphorylation-45.9024719451
43 (in isoform 2)Phosphorylation-45.90-
44PhosphorylationISSEKASSTPSSETQ
CCCCCCCCCCCCHHH		49.5520044836
44 (in isoform 1)Phosphorylation-49.5524719451
44 (in isoform 2)Phosphorylation-49.55-
45PhosphorylationSSEKASSTPSSETQE
CCCCCCCCCCCHHHH		25.3725159151
45 (in isoform 1)Phosphorylation-25.37-
45 (in isoform 2)Phosphorylation-25.37-
47PhosphorylationEKASSTPSSETQEEF
CCCCCCCCCHHHHHH		40.6825159151
47 (in isoform 1)Phosphorylation-40.68-
47 (in isoform 2)Phosphorylation-40.68-
48PhosphorylationKASSTPSSETQEEFV
CCCCCCCCHHHHHHH		45.9620044836
48 (in isoform 1)Phosphorylation-45.9624719451
48 (in isoform 2)Phosphorylation-45.96-
50PhosphorylationSSTPSSETQEEFVDD
CCCCCCHHHHHHHHH		43.1425159151
119O-linked_GlycosylationEPLKGIFTRPSKLTR
EECCCCCCCHHHCCC		39.4930059200
123MalonylationGIFTRPSKLTRKVQA
CCCCCHHHCCCCCCC		57.4726320211
139O-linked_GlycosylationDEANGLQTTPASRAT
HHCCCCCCCCCHHCC		39.5330059200
139PhosphorylationDEANGLQTTPASRAT
HHCCCCCCCCCHHCC		39.5330183078
140O-linked_GlycosylationEANGLQTTPASRATS
HCCCCCCCCCHHCCC		12.1430059200
140PhosphorylationEANGLQTTPASRATS
HCCCCCCCCCHHCCC		12.1422167270
140 (in isoform 1)Phosphorylation-12.14-
140 (in isoform 2)Phosphorylation-12.14-
143O-linked_GlycosylationGLQTTPASRATSPLC
CCCCCCCHHCCCCCC		24.5330059200
143PhosphorylationGLQTTPASRATSPLC
CCCCCCCHHCCCCCC		24.5322167270
143 (in isoform 1)Phosphorylation-24.5324719451
143 (in isoform 2)Phosphorylation-24.53-
146PhosphorylationTTPASRATSPLCTST
CCCCHHCCCCCCCCH		29.7523401153
146 (in isoform 1)Phosphorylation-29.7524719451
146 (in isoform 2)Phosphorylation-29.75-
147PhosphorylationTPASRATSPLCTSTA
CCCHHCCCCCCCCHH		18.1922167270
147 (in isoform 1)Phosphorylation-18.19-
147 (in isoform 2)Phosphorylation-18.19-
151PhosphorylationRATSPLCTSTASMVS
HCCCCCCCCHHHHCC		36.4722167270
152PhosphorylationATSPLCTSTASMVSS
CCCCCCCCHHHHCCC		22.4522167270
153PhosphorylationTSPLCTSTASMVSSS
CCCCCCCHHHHCCCC		12.4722167270
155PhosphorylationPLCTSTASMVSSSPS
CCCCCHHHHCCCCCC		21.5822167270
158PhosphorylationTSTASMVSSSPSTPS
CCHHHHCCCCCCCCC		19.2325159151
158 (in isoform 1)Phosphorylation-19.2324719451
159PhosphorylationSTASMVSSSPSTPSN
CHHHHCCCCCCCCCC		34.5523927012
159 (in isoform 1)Phosphorylation-34.5524719451
160PhosphorylationTASMVSSSPSTPSNI
HHHHCCCCCCCCCCC		18.5025159151
160 (in isoform 1)Phosphorylation-18.50-
160 (in isoform 2)Phosphorylation-18.50-
162PhosphorylationSMVSSSPSTPSNIPQ
HHCCCCCCCCCCCCC		55.7023927012
162 (in isoform 1)Phosphorylation-55.70-
162 (in isoform 2)Phosphorylation-55.70-
163PhosphorylationMVSSSPSTPSNIPQK
HCCCCCCCCCCCCCC		33.8325159151
163 (in isoform 1)Phosphorylation-33.83-
163 (in isoform 2)Phosphorylation-33.83-
165PhosphorylationSSSPSTPSNIPQKPS
CCCCCCCCCCCCCCC		47.7023927012
172PhosphorylationSNIPQKPSQPAAKEP
CCCCCCCCCCCCCCC		56.6923927012
172 (in isoform 1)Phosphorylation-56.69-
172 (in isoform 2)Phosphorylation-56.69-
180PhosphorylationQPAAKEPSATPPISN
CCCCCCCCCCCCCCH		45.9630266825
180 (in isoform 1)Phosphorylation-45.96-
180 (in isoform 2)Phosphorylation-45.96-
182PhosphorylationAAKEPSATPPISNLT
CCCCCCCCCCCCHHC		33.6630266825
182 (in isoform 1)Phosphorylation-33.6624719451
182 (in isoform 2)Phosphorylation-33.66-
186PhosphorylationPSATPPISNLTKTAS
CCCCCCCCHHCHHHH		31.4022199227
189O-linked_GlycosylationTPPISNLTKTASESI
CCCCCHHCHHHHHHH		30.5130059200
189PhosphorylationTPPISNLTKTASESI
CCCCCHHCHHHHHHH		30.5122199227
191PhosphorylationPISNLTKTASESISN
CCCHHCHHHHHHHHC		30.1323927012
191 (in isoform 1)Phosphorylation-30.13-
191 (in isoform 2)Phosphorylation-30.13-
193PhosphorylationSNLTKTASESISNLS
CHHCHHHHHHHHCHH		36.7920044836
193 (in isoform 1)Phosphorylation-36.79-
193 (in isoform 2)Phosphorylation-36.79-
195PhosphorylationLTKTASESISNLSEA
HCHHHHHHHHCHHHC		28.9019664994
195 (in isoform 1)Phosphorylation-28.9024719451
195 (in isoform 2)Phosphorylation-28.90-
197PhosphorylationKTASESISNLSEAGS
HHHHHHHHCHHHCCC		40.7823927012
197 (in isoform 1)Phosphorylation-40.78-
197 (in isoform 2)Phosphorylation-40.78-
200PhosphorylationSESISNLSEAGSIKK
HHHHHCHHHCCCCCC		29.6519664994
200 (in isoform 1)Phosphorylation-29.6524719451
200 (in isoform 2)Phosphorylation-29.65-
204PhosphorylationSNLSEAGSIKKGERE
HCHHHCCCCCCCCCE		37.9819664994
204 (in isoform 1)Phosphorylation-37.9824719451
204 (in isoform 2)Phosphorylation-37.9821406692
224MalonylationRVLVGGTKAGVVRFL
EEEECCCCCCHHHHC		46.5526320211
260PhosphorylationNDGAVAGTRYFQCQP
CCCCCCCCEEEEECC		16.6824670416
262PhosphorylationGAVAGTRYFQCQPKY
CCCCCCEEEEECCCC		9.61-
268AcetylationRYFQCQPKYGLFAPV
EEEEECCCCCCCCCC		26.5226051181
269PhosphorylationYFQCQPKYGLFAPVH
EEEECCCCCCCCCCC		26.24-
279PhosphorylationFAPVHKVTKIGFPST
CCCCCEEEECCCCCC		23.03-
285PhosphorylationVTKIGFPSTTPAKAK
EEECCCCCCCCHHHH		42.5228176443
285 (in isoform 1)Phosphorylation-42.5224719451
285 (in isoform 2)Phosphorylation-42.52-
286PhosphorylationTKIGFPSTTPAKAKA
EECCCCCCCCHHHHH		36.7216964243
286 (in isoform 1)Phosphorylation-36.72-
286 (in isoform 2)Phosphorylation-36.72-
287PhosphorylationKIGFPSTTPAKAKAN
ECCCCCCCCHHHHHH		26.1125159151
287 (in isoform 1)Phosphorylation-26.11-
287 (in isoform 2)Phosphorylation-26.11-
302O-linked_GlycosylationAVRRVMATTSASLKR
HHHHHHHHCCHHHCC		11.8230059200
302PhosphorylationAVRRVMATTSASLKR
HHHHHHHHCCHHHCC		11.8229978859
303PhosphorylationVRRVMATTSASLKRS
HHHHHHHCCHHHCCC		16.8629255136
304O-linked_GlycosylationRRVMATTSASLKRSP
HHHHHHCCHHHCCCC		16.1130059200
304PhosphorylationRRVMATTSASLKRSP
HHHHHHCCHHHCCCC		16.1129255136
306PhosphorylationVMATTSASLKRSPSA
HHHHCCHHHCCCCCC		33.9029255136
310PhosphorylationTSASLKRSPSASSLS
CCHHHCCCCCCHHHH		22.9420044836
310 (in isoform 1)Phosphorylation-22.9424719451
310 (in isoform 2)Phosphorylation-22.94-
312PhosphorylationASLKRSPSASSLSSM
HHHCCCCCCHHHHHH		41.8726055452
312 (in isoform 1)Phosphorylation-41.8724719451
312 (in isoform 2)Phosphorylation-41.87-
314PhosphorylationLKRSPSASSLSSMSS
HCCCCCCHHHHHHHH		35.8323898821
315PhosphorylationKRSPSASSLSSMSSV
CCCCCCHHHHHHHHH		31.8020044836
315 (in isoform 1)Phosphorylation-31.80-
315 (in isoform 2)Phosphorylation-31.80-
317PhosphorylationSPSASSLSSMSSVAS
CCCCHHHHHHHHHHH		26.4126503892
317 (in isoform 1)Phosphorylation-26.41-
317 (in isoform 2)Phosphorylation-26.41-
318PhosphorylationPSASSLSSMSSVASS
CCCHHHHHHHHHHHH		28.1623663014
320PhosphorylationASSLSSMSSVASSVS
CHHHHHHHHHHHHCC		24.4926503892
321PhosphorylationSSLSSMSSVASSVSS
HHHHHHHHHHHHCCC		17.0422199227
324PhosphorylationSSMSSVASSVSSRPS
HHHHHHHHHCCCCCC		29.1722199227
325PhosphorylationSMSSVASSVSSRPSR
HHHHHHHHCCCCCCC		19.1122199227
327PhosphorylationSSVASSVSSRPSRTG
HHHHHHCCCCCCCCC		23.6822199227
328PhosphorylationSVASSVSSRPSRTGL
HHHHHCCCCCCCCCC		46.1622199227
328 (in isoform 1)Phosphorylation-46.16-
328 (in isoform 2)Phosphorylation-46.16-
331PhosphorylationSSVSSRPSRTGLLTE
HHCCCCCCCCCCCCH		41.1722199227
331 (in isoform 1)Phosphorylation-41.17-
331 (in isoform 2)Phosphorylation-41.17-
333PhosphorylationVSSRPSRTGLLTETS
CCCCCCCCCCCCHHH		36.2023403867
337PhosphorylationPSRTGLLTETSSRYA
CCCCCCCCHHHHHHH		42.1123403867
339PhosphorylationRTGLLTETSSRYARK
CCCCCCHHHHHHHHH		27.1128857561
340PhosphorylationTGLLTETSSRYARKI
CCCCCHHHHHHHHHH		13.4428857561
341PhosphorylationGLLTETSSRYARKIS
CCCCHHHHHHHHHHH		36.4128857561
348PhosphorylationSRYARKISGTTALQE
HHHHHHHHCHHHHHH		32.8729255136
348 (in isoform 1)Phosphorylation-32.8724719451
348 (in isoform 2)Phosphorylation-32.87-
350PhosphorylationYARKISGTTALQEAL
HHHHHHCHHHHHHHH		11.3430266825
351PhosphorylationARKISGTTALQEALK
HHHHHCHHHHHHHHH		28.9730266825
351 (in isoform 1)Phosphorylation-28.97-
351 (in isoform 2)Phosphorylation-28.97-
360MalonylationLQEALKEKQQHIEQL
HHHHHHHHHHHHHHH		54.3826320211
382PhosphorylationRAEVAKATSHVGEIE
HHHHHHHHCCHHHHH		20.7527050516
383PhosphorylationAEVAKATSHVGEIEQ
HHHHHHHCCHHHHHH		22.4927050516
4242-HydroxyisobutyrylationVEAADREKVELLNQL
HHHHHHHHHHHHHHH		41.73-
449PhosphorylationQFRVEEESITKGDLE
HHHHHHHCCCCCCHH		38.5521815630
449 (in isoform 2)Phosphorylation-38.5521712546
451 (in isoform 2)Phosphorylation-37.9521712546
459 (in isoform 2)Phosphorylation-32.2321406692
461 (in isoform 2)Phosphorylation-6.6821406692
464 (in isoform 2)Phosphorylation-49.3621406692
499 (in isoform 1)Phosphorylation-53.2124719451
501PhosphorylationLQRELEDTRVATVSE
HHHHHCCCCEECHHH		20.0523403867
505PhosphorylationLEDTRVATVSEKSRI
HCCCCEECHHHHHHH		23.0023403867
507PhosphorylationDTRVATVSEKSRIME
CCCEECHHHHHHHHH		34.6523403867
5092-HydroxyisobutyrylationRVATVSEKSRIMELE
CEECHHHHHHHHHHH		37.21-
510PhosphorylationVATVSEKSRIMELEK
EECHHHHHHHHHHHH		24.0023401153
547PhosphorylationGDVDMSLSLLQEISS
CCCHHHHHHHHHHHH		21.5225332170
553PhosphorylationLSLLQEISSLQEKLE
HHHHHHHHHHHHHHC		25.0125332170
561 (in isoform 2)Phosphorylation-6.77-
592PhosphorylationQKEIKALYTATEKLS
HHHHHHHHHHHHHHH		10.1326270265
593PhosphorylationKEIKALYTATEKLSK
HHHHHHHHHHHHHHH		28.1426270265
595PhosphorylationIKALYTATEKLSKEN
HHHHHHHHHHHHHHC		26.3326270265
596PhosphorylationKALYTATEKLSKENE
HHHHHHHHHHHHHCH		49.9220068231
596 (in isoform 1)Phosphorylation-49.92-
597AcetylationALYTATEKLSKENES
HHHHHHHHHHHHCHH		54.4226051181
607PhosphorylationKENESLKSKLEHANK
HHCHHHHHHHHHHHH		48.0020068231
633 (in isoform 1)Phosphorylation-18.7324719451
644PhosphorylationAMEELKVSFSKGLGT
HHHHHCHHHHCCCCH		23.4024719451
7062-HydroxyisobutyrylationLMKVIKEKENSLEAI
HHHHHHHHHHHHHHH		58.14-
706AcetylationLMKVIKEKENSLEAI
HHHHHHHHHHHHHHH		58.1425953088
706MalonylationLMKVIKEKENSLEAI
HHHHHHHHHHHHHHH		58.1426320211
709PhosphorylationVIKEKENSLEAIRSK
HHHHHHHHHHHHHHH		28.7821955146
728SulfoxidationEDQHLVEMEDTLNKL
HHHHHHHHHHHHHHH		4.3830846556
783PhosphorylationLDALRKASSEGKSEM
HHHHHHHHHHCHHHH		31.77-
784PhosphorylationDALRKASSEGKSEMK
HHHHHHHHHCHHHHH		56.05-
787 (in isoform 2)Phosphorylation-38.91-
788PhosphorylationKASSEGKSEMKKLRQ
HHHHHCHHHHHHHHH		54.50-
815PhosphorylationEIEKNAESSKASSIT
HHHHCCCCCHHHHHH		34.43-
822PhosphorylationSSKASSITRELQGRE
CCHHHHHHHHHCCCC		21.7518452278
822 (in isoform 1)Phosphorylation-21.75-
833PhosphorylationQGRELKLTNLQENLS
CCCCHHHHHHHHHHH		32.0920044836
840PhosphorylationTNLQENLSEVSQVKE
HHHHHHHHHHHHHHH		47.75-
843PhosphorylationQENLSEVSQVKETLE
HHHHHHHHHHHHHHH		25.79-
848PhosphorylationEVSQVKETLEKELQI
HHHHHHHHHHHHHHH		34.20-
874SulfoxidationAVSVQRSMQETVNKL
HHHHHHHHHHHHHHH		4.5530846556
890SulfoxidationQKEEQFNMLSSDLEK
HHHHHHHHHHHHHHH		3.9721406390
905SulfoxidationLRENLADMEAKFREK
HHHHHHHHHHHHHHH		4.4830846556
936SulfoxidationDIAEIMKMSGDNSSQ
HHHHHHHHHCCCHHH		2.7530846556
937PhosphorylationIAEIMKMSGDNSSQL
HHHHHHHHCCCHHHH		37.1621082442
941PhosphorylationMKMSGDNSSQLTKMN
HHHHCCCHHHHHHHC		24.9720860994
963 (in isoform 2)Phosphorylation-8.41-
973PhosphorylationTKANENASFLQKSIE
HHHHHCHHHHHHHHH		37.7625159151
978PhosphorylationNASFLQKSIEDMTVK
CHHHHHHHHHHHHHH		20.4628270605
982SulfoxidationLQKSIEDMTVKAEQS
HHHHHHHHHHHHHHH		2.7730846556
983PhosphorylationQKSIEDMTVKAEQSQ
HHHHHHHHHHHHHHH		31.0428270605
989O-linked_GlycosylationMTVKAEQSQQEAAKK
HHHHHHHHHHHHHHH		25.9030059200
989PhosphorylationMTVKAEQSQQEAAKK
HHHHHHHHHHHHHHH		25.9028270605
998PhosphorylationQEAAKKHEEEKKELE
HHHHHHHHHHHHHHH		76.3920068231
998 (in isoform 1)Phosphorylation-76.3924719451
1007AcetylationEKKELERKLSDLEKK
HHHHHHHHHHHHHHH		42.8612437707
1009PhosphorylationKELERKLSDLEKKME
HHHHHHHHHHHHHHH		43.0923911959
1013AcetylationRKLSDLEKKMETSHN
HHHHHHHHHHHHCHH		65.7912437719
1015SulfoxidationLSDLEKKMETSHNQC
HHHHHHHHHHCHHHH		11.4230846556
1026AcetylationHNQCQELKARYERAT
HHHHHHHHHHHHHHH		30.0225953088
1033PhosphorylationKARYERATSETKTKH
HHHHHHHHHCHHHHH		33.0621406692
1034PhosphorylationARYERATSETKTKHE
HHHHHHHHCHHHHHH		42.1421406692
1036PhosphorylationYERATSETKTKHEEI
HHHHHHCHHHHHHHH		43.7221406692
1038PhosphorylationRATSETKTKHEEILQ
HHHHCHHHHHHHHHH		45.0821406692
1039AcetylationATSETKTKHEEILQN
HHHCHHHHHHHHHHH		51.0427452117
1039MalonylationATSETKTKHEEILQN
HHHCHHHHHHHHHHH		51.0432601280
10572-HydroxyisobutyrylationTLLDTEDKLKGAREE
HHCCCHHHHHHHHHH		45.96-
1066PhosphorylationKGAREENSGLLQELE
HHHHHHCCHHHHHHH		33.81-
1087PhosphorylationDKAKAAQTAEDAMQI
HHHHHHHHHHHHHHH		27.56-
1099 (in isoform 2)Phosphorylation-35.43-
1105PhosphorylationMTKEKTETLASLEDT
HHHHHHHHHHCHHHH		32.6230576142
1108PhosphorylationEKTETLASLEDTKQT
HHHHHHHCHHHHHHH		35.0921815630
1112PhosphorylationTLASLEDTKQTNAKL
HHHCHHHHHHHHHHH		18.7130576142
1115PhosphorylationSLEDTKQTNAKLQNE
CHHHHHHHHHHHHHH		38.4030576142
1140PhosphorylationNVEELNKSKELLTVE
CHHHHHHCCHHHHHC		30.2326055452
1145PhosphorylationNKSKELLTVENQKME
HHCCHHHHHCHHHHH		38.1026270265
1169PhosphorylationKQAAAQKSQQLSALQ
HHHHHHHHHHHHHHH		15.8721659604
1188 (in isoform 2)Phosphorylation-40.94-
1190 (in isoform 2)Phosphorylation-42.63-
1204PhosphorylationQKLEEERSVLNNQLL
HHHHHHHHHHHHHHH		33.9530622161
12142-HydroxyisobutyrylationNNQLLEMKKRESKFI
HHHHHHHHHHHHHCC		39.03-
1225 (in isoform 2)Phosphorylation-74.79-
1230PhosphorylationDADEEKASLQKSISI
CCHHHHHHHHHHHHH		42.26-
1234PhosphorylationEKASLQKSISITSAL
HHHHHHHHHHHHHHH		14.4928258704
1236PhosphorylationASLQKSISITSALLT
HHHHHHHHHHHHHHC		27.2328258704
1238PhosphorylationLQKSISITSALLTEK
HHHHHHHHHHHHCCC		10.9329523821
1239PhosphorylationQKSISITSALLTEKD
HHHHHHHHHHHCCCH		18.43-
1265PhosphorylationVLRGENASAKSLHSV
EHHCCCCCHHHHHHH		48.0528387310
1271PhosphorylationASAKSLHSVVQTLES
CCHHHHHHHHHHHHC		29.31-
1302PhosphorylationKENKRQLSSSSGNTD
HHHHHHHHCCCCCCC		21.6023663014
1303PhosphorylationENKRQLSSSSGNTDT
HHHHHHHCCCCCCCC		36.8023663014
1304PhosphorylationNKRQLSSSSGNTDTQ
HHHHHHCCCCCCCCC		38.6023663014
1305PhosphorylationKRQLSSSSGNTDTQA
HHHHHCCCCCCCCCC		37.7023663014
1308PhosphorylationLSSSSGNTDTQADED
HHCCCCCCCCCCCHH		43.9023663014
1310PhosphorylationSSSGNTDTQADEDER
CCCCCCCCCCCHHHH		24.5023663014
1316 (in isoform 2)Phosphorylation-48.12-
1318 (in isoform 2)Phosphorylation-18.55-
1351PhosphorylationVEMMSEAALNGNGDD
HHHHHHHHHCCCCCC		9.4818669648
1351 (in isoform 1)Phosphorylation-9.48-
1353PhosphorylationMMSEAALNGNGDDLN
HHHHHHHCCCCCCCC		36.8419651622
1353 (in isoform 1)Phosphorylation-36.84-
1362PhosphorylationNGDDLNNYDSDDQEK
CCCCCCCCCCCHHHH		18.7530278072
1364PhosphorylationDDLNNYDSDDQEKQS
CCCCCCCCCHHHHHH		32.5030278072
1371PhosphorylationSDDQEKQSKKKPRLF
CCHHHHHHHCCCCCE		58.4722210691
1384 (in isoform 2)Phosphorylation-2.18-
1430PhosphorylationEMFGHWATNCNDDET
HHHCCHHCCCCCCCC		34.80-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
13TPhosphorylationKinaseLRRK1Q38SD2
PSP
27TPhosphorylationKinaseLRRK1Q38SD2
PSP
36TPhosphorylationKinaseLRRK1Q38SD2
PSP
191TPhosphorylationKinaseLRRK1Q38SD2
PSP
195SPhosphorylationKinasePLK1P53350
PSP
312SPhosphorylationKinasePKA-Uniprot
312SPhosphorylationKinasePLK1P53350
PSP
312SPhosphorylationKinasePKN3Q6P5Z2
PSP
312SPhosphorylationKinasePKN1Q16512
PSP
459TPhosphorylationKinaseLRRK1Q38SD2
PSP
1099TPhosphorylationKinaseLRRK1Q38SD2
PSP
1188SPhosphorylationKinaseLRRK1Q38SD2
PSP
1190SPhosphorylationKinaseLRRK1Q38SD2
PSP
1225SPhosphorylationKinaseLRRK1Q38SD2
PSP
1318SPhosphorylationKinaseLRRK1Q38SD2
PSP
1364SPhosphorylationKinasePLK1P53350
PSP
1364SPhosphorylationKinaseCSNK2A1P68400
GPS
1384TPhosphorylationKinaseLRRK1Q38SD2
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLIP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLIP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTOR_HUMANMTORphysical
12231510
CDC42_HUMANCDC42physical
12110184
RAC1_HUMANRAC1physical
12110184
LIS1_HUMANPAFAH1B1physical
11940666
BIN1_HUMANBIN1physical
19004523
MARE1_HUMANMAPRE1physical
16455083
HDAC6_HUMANHDAC6physical
24474193
CHD4_HUMANCHD4physical
26344197
CSN1_HUMANGPS1physical
26344197
MARE1_HUMANMAPRE1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLIP1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195; SER-200 ANDSER-204, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182; SER-193; SER-195;SER-200; SER-204 AND SER-1364, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45; SER-48; THR-140;SER-143; SER-147; THR-182; SER-197; SER-200 AND SER-204, AND MASSSPECTROMETRY.
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195; SER-200 ANDTHR-833, AND MASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182 AND SER-195, ANDMASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200 AND SER-204, ANDMASS SPECTROMETRY.
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, AND MASSSPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, AND MASSSPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182, AND MASSSPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182, AND MASSSPECTROMETRY.

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