dbPTM

TREF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TREF1_HUMAN
UniProt AC	Q96PN7
Protein Name	Transcriptional-regulating factor 1
Gene Name	TRERF1
Organism	Homo sapiens (Human).
Sequence Length	1200
Subcellular Localization	Nucleus .
Protein Description	Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1..
Protein Sequence	MGDQQLYKTNHVAHGSENLFYQQPPLGVHSGLNHNYGNAVTGGGMDAPQASPISPHFPQDTRDGLGLPVGSKNLGQMDTSRQGGWGSHAGPGNHVQLRGNLANSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSALRQLLSQKPMEPPAPAIPSRYQQVPQQPHPGFTGGLSKPALQVGQHPTQGHLYYDYQQPLAQVPVQGGQPLQAPQMLSQHMQQMQQHQYYPPQQQQQAGQQRISMQEIQTQPQQIRPSQPQPPPQQQQPQQLQLQQRQGSMQIPQYYQPQPMMQHLQEQQQQQMHLQPPSYHRDPHQYTPEQAHTVQLIPLGSMSQYYYQEPQQPYSHPLYQQSHLSQHQQREDSQLKTYSSDRQAQAMLSSHGDLGPPDTGMGDPASSDLTRVSSTLPHRPLLSPSGIHLNNMGPQHQQLSPSAMWPQMHLPDGRAQPGSPESSGQPKGAFGEQFDAKNKLTCSICLKEFKNLPALNGHMRSHGGMRASPNLKQEEGEKVLPPQPQPPLPPPPPPPPPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFTNSTVAAPSARDKPASSMSDDEMPVLEIPRKHQPSVPKAEEPLKTVQEKKKFRHRPEPLFIPPPPSYNPNPAASYSGATLYQSQLRSPRVLGDHLLLDPTHELPPYTPPPMLSPVRQGSGLFSNVLISGHGPGAHPQLPLTPLTPTPRVLLCRSNSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDISALAQDTHKATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMVALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCVTSEEEEELEEEEEEDPEEDRKSTKEEESEVPKSPEPPPVPVLAPTEGPPLQALGQPSGSFICEMPNCGAVFSSRQALNGHARIHGGTNQVTKARGAIPSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPGLLPLDQLSLIKPIKDVDILDDDVVQQLGGVMEEAEVVDTDLLLDDQDSVLLQGDAEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27 (in isoform 2)	Ubiquitination	-	22.36	21890473
27 (in isoform 3)	Ubiquitination	-	22.36	21890473
41	Phosphorylation	HNYGNAVTGGGMDAP CCCCCCCCCCCCCCC	27.91	28348404
51	Phosphorylation	GMDAPQASPISPHFP CCCCCCCCCCCCCCC	19.95	26074081
54	Phosphorylation	APQASPISPHFPQDT CCCCCCCCCCCCCCC	18.73	26074081
72	Sumoylation	LGLPVGSKNLGQMDT CCCCCCCCCCCCCCC	50.71	-
72	Sumoylation	LGLPVGSKNLGQMDT CCCCCCCCCCCCCCC	50.71	-
72	Ubiquitination	LGLPVGSKNLGQMDT CCCCCCCCCCCCCCC	50.71	-
104	Phosphorylation	LRGNLANSNMMWGAP EECCCCCCCCCCCCC	22.09	30576142
120	Phosphorylation	QAEPTDGYQYTYSQA CCCCCCCCCEEECCH	10.93	30576142
122	Phosphorylation	EPTDGYQYTYSQASE CCCCCCCEEECCHHH	10.12	20090780
134	Ubiquitination	ASEIRTQKLTSGVLH HHHHHHCCCCHHHHH	53.79	-
136	Phosphorylation	EIRTQKLTSGVLHKL HHHHCCCCHHHHHHH	30.39	27251275
137	Phosphorylation	IRTQKLTSGVLHKLD HHHCCCCHHHHHHHH	37.02	27251275
145	Phosphorylation	GVLHKLDSFTQVFAN HHHHHHHHHHHHHCC	40.40	27080861
147	Phosphorylation	LHKLDSFTQVFANQN HHHHHHHHHHHCCCC	27.98	27080861
188	Acetylation	LRQLLSQKPMEPPAP HHHHHCCCCCCCCCC	42.85	26051181
188	Ubiquitination	LRQLLSQKPMEPPAP HHHHHCCCCCCCCCC	42.85	21906983
188 (in isoform 1)	Ubiquitination	-	42.85	21890473
188 (in isoform 4)	Ubiquitination	-	42.85	21890473
188 (in isoform 5)	Ubiquitination	-	42.85	21890473
379 (in isoform 2)	Phosphorylation	-	11.06	-
379 (in isoform 3)	Phosphorylation	-	11.06	-
408	Ubiquitination	QREDSQLKTYSSDRQ HHHHHHHHHHCHHHH	37.47	-
421	Phosphorylation	RQAQAMLSSHGDLGP HHHHHHHHHCCCCCC	13.75	22210691
422	Phosphorylation	QAQAMLSSHGDLGPP HHHHHHHHCCCCCCC	27.77	22210691
445	Phosphorylation	SSDLTRVSSTLPHRP CCCCCEECCCCCCCC	17.83	27251275
446	Phosphorylation	SDLTRVSSTLPHRPL CCCCEECCCCCCCCC	30.98	27251275
447	Phosphorylation	DLTRVSSTLPHRPLL CCCEECCCCCCCCCC	36.48	27251275
455	Phosphorylation	LPHRPLLSPSGIHLN CCCCCCCCCCCCCCC	25.38	28348404
457	Phosphorylation	HRPLLSPSGIHLNNM CCCCCCCCCCCCCCC	47.18	27251275
472	Phosphorylation	GPQHQQLSPSAMWPQ CHHCCCCCHHHCCCC	16.69	27251275
474	Phosphorylation	QHQQLSPSAMWPQMH HCCCCCHHHCCCCCC	27.64	28348404
491	Phosphorylation	DGRAQPGSPESSGQP CCCCCCCCCCCCCCC	31.98	23401153
494	Phosphorylation	AQPGSPESSGQPKGA CCCCCCCCCCCCCCC	43.06	30266825
495	Phosphorylation	QPGSPESSGQPKGAF CCCCCCCCCCCCCCC	39.52	30266825
509	Sumoylation	FGEQFDAKNKLTCSI CCCCCCCCCCEEEEE	57.36	-
509	Acetylation	FGEQFDAKNKLTCSI CCCCCCCCCCEEEEE	57.36	25953088
509	Sumoylation	FGEQFDAKNKLTCSI CCCCCCCCCCEEEEE	57.36	-
519	Acetylation	LTCSICLKEFKNLPA EEEEEHHHHHCCCCH	57.61	26051181
522	Sumoylation	SICLKEFKNLPALNG EEHHHHHCCCCHHCC	59.68	-
522	Sumoylation	SICLKEFKNLPALNG EEHHHHHCCCCHHCC	59.68	-
540	Phosphorylation	SHGGMRASPNLKQEE CCCCCCCCCCCCHHH	12.17	25849741
540 (in isoform 4)	Phosphorylation	-	12.17	-
540 (in isoform 5)	Phosphorylation	-	12.17	-
544	Sumoylation	MRASPNLKQEEGEKV CCCCCCCCHHHCCCC	63.40	-
544	Sumoylation	MRASPNLKQEEGEKV CCCCCCCCHHHCCCC	63.40	-
568 (in isoform 2)	Ubiquitination	-	60.00	21890473
568 (in isoform 3)	Ubiquitination	-	60.00	21890473
603	Phosphorylation	KPSSQGFTNSTVAAP CCCCCCCCCCCCCCC	34.77	28555341
618	Phosphorylation	SARDKPASSMSDDEM CCCCCCCCCCCCCCC	34.79	30266825
619	Phosphorylation	ARDKPASSMSDDEMP CCCCCCCCCCCCCCC	25.14	30266825
621	Phosphorylation	DKPASSMSDDEMPVL CCCCCCCCCCCCCEE	43.81	30266825
633	Acetylation	PVLEIPRKHQPSVPK CEEECCCCCCCCCCC	41.03	-
637	Phosphorylation	IPRKHQPSVPKAEEP CCCCCCCCCCCCCCC	44.47	-
640	Sumoylation	KHQPSVPKAEEPLKT CCCCCCCCCCCCCCH	67.29	-
640	Acetylation	KHQPSVPKAEEPLKT CCCCCCCCCCCCCCH	67.29	-
640	Sumoylation	KHQPSVPKAEEPLKT CCCCCCCCCCCCCCH	67.29	-
646	Acetylation	PKAEEPLKTVQEKKK CCCCCCCCHHHHHHC	58.32	25953088
676	Phosphorylation	YNPNPAASYSGATLY CCCCCCCCCCCCEEE	23.18	23401153
677	Phosphorylation	NPNPAASYSGATLYQ CCCCCCCCCCCEEEH	13.34	28152594
678	Phosphorylation	PNPAASYSGATLYQS CCCCCCCCCCEEEHH	21.32	28152594
681	Phosphorylation	AASYSGATLYQSQLR CCCCCCCEEEHHHCC	29.53	28152594
683	Phosphorylation	SYSGATLYQSQLRSP CCCCCEEEHHHCCCC	11.19	28152594
685	Phosphorylation	SGATLYQSQLRSPRV CCCEEEHHHCCCCCC	20.02	28152594
689	Phosphorylation	LYQSQLRSPRVLGDH EEHHHCCCCCCCCCC	26.17	28464451
702	Phosphorylation	DHLLLDPTHELPPYT CCCCCCCCCCCCCCC	27.87	28450419
708	Phosphorylation	PTHELPPYTPPPMLS CCCCCCCCCCCCCCC	29.91	30108239
709	Phosphorylation	THELPPYTPPPMLSP CCCCCCCCCCCCCCC	34.78	21712546
715	Phosphorylation	YTPPPMLSPVRQGSG CCCCCCCCCCCCCCC	18.33	22617229
721	Phosphorylation	LSPVRQGSGLFSNVL CCCCCCCCCCCCCEE	24.80	20068231
725	Phosphorylation	RQGSGLFSNVLISGH CCCCCCCCCEEEECC	30.95	20068231
729 (in isoform 4)	Ubiquitination	-	3.95	21890473
729 (in isoform 5)	Ubiquitination	-	3.95	21890473
730	Phosphorylation	LFSNVLISGHGPGAH CCCCEEEECCCCCCC	22.15	26657352
743	Phosphorylation	AHPQLPLTPLTPTPR CCCCCCCCCCCCCCE	17.82	27273156
746	Phosphorylation	QLPLTPLTPTPRVLL CCCCCCCCCCCEEEE	26.73	27273156
748	Phosphorylation	PLTPLTPTPRVLLCR CCCCCCCCCEEEEEE	20.63	27273156
756	Phosphorylation	PRVLLCRSNSIDGSN CEEEEEECCCCCCCC	33.65	30278072
758	Phosphorylation	VLLCRSNSIDGSNVT EEEEECCCCCCCCCE	24.25	30278072
762	Phosphorylation	RSNSIDGSNVTVTPG ECCCCCCCCCEECCC	25.12	23927012
765	Phosphorylation	SIDGSNVTVTPGPGE CCCCCCCEECCCCCC	23.94	23927012
767	Phosphorylation	DGSNVTVTPGPGEQT CCCCCEECCCCCCCE	17.11	23927012
774	Phosphorylation	TPGPGEQTVDVEPRI CCCCCCCEEECCCCC	17.86	23927012
812	Ubiquitination	HKATLVWKPWPELEN CHHEEEEECCHHHCC	29.71	21890473
812 (in isoform 1)	Ubiquitination	-	29.71	21890473
892	Phosphorylation	AGSDKWTSLERKLFN CCCCCCCHHHHHHHH	27.41	-
907	Acetylation	KALATYSKDFIFVQK HHHHHHCCCEEEEHH	46.36	19821629
914	Acetylation	KDFIFVQKMVKSKTV CCEEEEHHHHCCCCH	40.12	24885407
917	Acetylation	IFVQKMVKSKTVAQC EEEHHHHCCCCHHHH	42.61	19821639
954	Phosphorylation	EIIDDCVTSEEEEEL HHHHHHCCCHHHHHH	36.43	30576142
955	Phosphorylation	IIDDCVTSEEEEELE HHHHHCCCHHHHHHH	23.71	30576142
975	Phosphorylation	DPEEDRKSTKEEESE CCHHHHHCHHHHHCC	45.68	25159151
976	Phosphorylation	PEEDRKSTKEEESEV CHHHHHCHHHHHCCC	45.57	27251275
981	Phosphorylation	KSTKEEESEVPKSPE HCHHHHHCCCCCCCC	47.36	22985185
986	Phosphorylation	EESEVPKSPEPPPVP HHCCCCCCCCCCCCC	28.55	23879269
1040	Phosphorylation	HARIHGGTNQVTKAR CCEECCCCCHHHCCC	27.37	30108239
1044	Phosphorylation	HGGTNQVTKARGAIP CCCCCHHHCCCCCCC	14.82	30108239
1052	Phosphorylation	KARGAIPSGKQKPGG CCCCCCCCCCCCCCC	53.13	24719451
1054	Acetylation	RGAIPSGKQKPGGTQ CCCCCCCCCCCCCCC	60.53	25953088
1056	Acetylation	AIPSGKQKPGGTQSG CCCCCCCCCCCCCCC	49.46	26051181
1062	Phosphorylation	QKPGGTQSGYCSVKS CCCCCCCCCEEEEEC	31.41	27794612
1064	Phosphorylation	PGGTQSGYCSVKSSP CCCCCCCEEEEECCC	6.18	27794612
1066	Phosphorylation	GTQSGYCSVKSSPSH CCCCCEEEEECCCCC	24.89	25056879
1069	Phosphorylation	SGYCSVKSSPSHSTT CCEEEEECCCCCCCC	45.38	23401153
1070	Phosphorylation	GYCSVKSSPSHSTTS CEEEEECCCCCCCCC	25.38	23927012
1072	Phosphorylation	CSVKSSPSHSTTSGE EEEECCCCCCCCCCC	31.83	23927012
1074	Phosphorylation	VKSSPSHSTTSGETD EECCCCCCCCCCCCC	37.40	25159151
1075	Phosphorylation	KSSPSHSTTSGETDP ECCCCCCCCCCCCCC	21.40	23927012
1076	Phosphorylation	SSPSHSTTSGETDPT CCCCCCCCCCCCCCC	37.44	23927012
1077	Phosphorylation	SPSHSTTSGETDPTT CCCCCCCCCCCCCCC	34.42	23927012
1080	Phosphorylation	HSTTSGETDPTTIFP CCCCCCCCCCCCEEE	51.29	25394399
1083	Phosphorylation	TSGETDPTTIFPCKE CCCCCCCCCEEECCH	35.02	23927012
1084	Phosphorylation	SGETDPTTIFPCKEC CCCCCCCCEEECCHH	26.47	23927012
1089	Acetylation	PTTIFPCKECGKVFF CCCEEECCHHCCEEE	57.17	26051181
1151	Phosphorylation	LLPLDQLSLIKPIKD EEEHHHHHHCCCCCC	23.55	24719451
1154	Acetylation	LDQLSLIKPIKDVDI HHHHHHCCCCCCCCC	46.08	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TREF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TREF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TREF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STF1_HUMAN	NR5A1	physical	12101186
TDIF1_HUMAN	DNTTIP1	physical	21258344
HDAC1_HUMAN	HDAC1	physical	21258344

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TREF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-767, AND MASSSPECTROMETRY.	19690332 [Abstract]