ZIC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZIC3_HUMAN
• UniProt AC: O60481
• Protein Name: Zinc finger protein ZIC 3
• Gene Name: ZIC3
• Organism: Homo sapiens (Human).
• Sequence Length: 467
• Subcellular Localization: Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6..
• Protein Description: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'..
• Protein Sequence: MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSPAAAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLFRQRSSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAAGAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIDEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	FPGLGVGSFGAPRHH CCCCCCCCCCCCCCC	20.35	-
59	Phosphorylation	AAAAFKLSPAAAHDL HHHHHHCCHHHHCCC	17.06	-
248	Sumoylation	RYMRQPIKQELSCKW HHCCCCCCHHHCCEE	44.39	28112733
248	Sumoylation	RYMRQPIKQELSCKW HHCCCCCCHHHCCEE	44.39	-
262	Phosphorylation	WIDEAQLSRPKKSCD ECCHHHHCCCHHHCC	34.16	23312004
323	Phosphorylation	VNHIRVHTGEKPFPC EEEEEEECCCCCCCC	44.15	-
351	Phosphorylation	NLKIHKRTHTGEKPF CCEEECCCCCCCCCE	28.70	23312004
353	Phosphorylation	KIHKRTHTGEKPFKC EEECCCCCCCCCEEC	46.56	29496963
383	Phosphorylation	KKHMHVHTSDKPYIC CCCEEEECCCCCCEE	37.22	26074081
384	Phosphorylation	KHMHVHTSDKPYICK CCEEEECCCCCCEEE	28.85	26074081
388	Phosphorylation	VHTSDKPYICKVCDK EECCCCCCEEEECCC	25.37	26074081
396	Phosphorylation	ICKVCDKSYTHPSSL EEEECCCCCCCHHHH	23.24	26074081
397	Phosphorylation	CKVCDKSYTHPSSLR EEECCCCCCCHHHHH	18.14	26074081
398	Phosphorylation	KVCDKSYTHPSSLRK EECCCCCCCHHHHHH	34.11	26074081
401	Phosphorylation	DKSYTHPSSLRKHMK CCCCCCHHHHHHHHH	34.11	27080861
402	Phosphorylation	KSYTHPSSLRKHMKV CCCCCHHHHHHHHHH	36.32	26074081
412	Phosphorylation	KHMKVHESQGSDSSP HHHHHHHHCCCCCCC	25.59	21406692
415	Phosphorylation	KVHESQGSDSSPAAS HHHHHCCCCCCCCHH	27.04	21406692
417	Phosphorylation	HESQGSDSSPAASSG HHHCCCCCCCCHHCC	39.66	21406692
418	Phosphorylation	ESQGSDSSPAASSGY HHCCCCCCCCHHCCC	24.45	21406692
422	Phosphorylation	SDSSPAASSGYESST CCCCCCHHCCCCCCC	26.80	21406692
423	Phosphorylation	DSSPAASSGYESSTP CCCCCHHCCCCCCCC	40.44	21406692
425	Phosphorylation	SPAASSGYESSTPPA CCCHHCCCCCCCCCC	18.00	21406692
427	Phosphorylation	AASSGYESSTPPAIA CHHCCCCCCCCCCCC	30.91	21406692
428	Phosphorylation	ASSGYESSTPPAIAS HHCCCCCCCCCCCCC	32.75	21406692
429	Phosphorylation	SSGYESSTPPAIASA HCCCCCCCCCCCCCC	42.44	21406692
435	Phosphorylation	STPPAIASANSKDTT CCCCCCCCCCCCCCC	23.13	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZIC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZIC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZIC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLI3_HUMAN	GLI3	physical	17764085
SRF_HUMAN	SRF	physical	17468179

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.