SALL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SALL4_HUMAN
• UniProt AC: Q9UJQ4
• Protein Name: Sal-like protein 4
• Gene Name: SALL4
• Organism: Homo sapiens (Human).
• Sequence Length: 1053
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells..
• Protein Sequence: MSRRKQAKPQHINSEEDQGEQQPQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDEATVKRLRREETHVCEKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHRENGGSSEDMKEKPDAESVVYLKTETALPPTPQDISYLAKGKVANTNVTLQALRGTKVAVNQRSADALPAPVPGANSIPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKTLGSHMSQQVSAAVALLSQKAGSQGLSLDALKQAKLPHANIPSATSSLSPGLAPFTLKPDGTRVLPNVMSRLPSALLPQAPGSVLFQSPFSTVALDTSKKGKGKPPNISAVDVKPKDEAALYKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVKANPQLFAEFQDKVAAGNGIPYALSVPDPIDEPSLSLDSKPVLVTTSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGGPTLPGVGPNYNSPRAGGFQGSGTPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPENPCDFTGSEPMTVGENGSTGAICHDDVIESIDVEEVSSQEAPSSSSKVPTPLPSIHSASPTLGFAMMASLDAPGKVGPAPFNLQRQGSRENGSVESDGLTNDSSSLMGDQEYQSRSPDILETTSFQALSPANSQAESIKSKSPDAGSKAESSENSRTEMEGRSSLPSTFIRAPPTYVKVEVPGTFVGPSTLSPGMTPLLAAQPRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENTMALLGTDGKRVSEIFPKEILAPSVNVDPVVWNQYTSMLNGGLAVKTNEISVIQSGGVPTLPVSLGATSVVNNATVSKMDGSQSGISADVEKPSATDGVPKHQFPHFLEENKIAVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	AKPQHINSEEDQGEQ CCCCCCCCCCHHCCC	41.58	21406692
27	Phosphorylation	EQQPQQQTPEFADAA CCCCCCCCHHHHHHC	22.05	21406692
57	Phosphorylation	PGNDEVASEDEATVK CCCCCCCCCCHHHHH	51.24	21406692
62	Phosphorylation	VASEDEATVKRLRRE CCCCCHHHHHHHHHH	25.22	21406692
95	Phosphorylation	LEHKKNCTKNPPVLI HHHHHCCCCCCCEEE	43.16	21406692
106	Phosphorylation	PVLIMNDSEGPVPSE CEEEECCCCCCCCCC	39.17	21406692
112	Phosphorylation	DSEGPVPSEDFSGAV CCCCCCCCCCCCCCH	50.46	30576142
116	Phosphorylation	PVPSEDFSGAVLSHQ CCCCCCCCCCHHCCC	37.86	30576142
121	Phosphorylation	DFSGAVLSHQPTSPG CCCCCHHCCCCCCCC	17.30	18669648
125	Phosphorylation	AVLSHQPTSPGSKDC CHHCCCCCCCCCCCC	40.77	21406692
126	Phosphorylation	VLSHQPTSPGSKDCH HHCCCCCCCCCCCCC	33.67	30576142
129	Phosphorylation	HQPTSPGSKDCHREN CCCCCCCCCCCCHHC	28.80	21406692
156	Sumoylation	AESVVYLKTETALPP CCCEEEEEECCCCCC	26.99	28112733
156 (in isoform 2)	Sumoylation	-	26.99	-
157	Phosphorylation	ESVVYLKTETALPPT CCEEEEEECCCCCCC	35.65	24043423
159	Phosphorylation	VVYLKTETALPPTPQ EEEEEECCCCCCCHH	38.43	24043423
164	Phosphorylation	TETALPPTPQDISYL ECCCCCCCHHHHHHH	31.48	24043423
169	Phosphorylation	PPTPQDISYLAKGKV CCCHHHHHHHHCCCC	23.53	24043423
170	Phosphorylation	PTPQDISYLAKGKVA CCHHHHHHHHCCCCC	15.83	24043423
173	Acetylation	QDISYLAKGKVANTN HHHHHHHCCCCCCCC	57.58	7685259
175	Sumoylation	ISYLAKGKVANTNVT HHHHHCCCCCCCCEE	37.15	-
175	Sumoylation	ISYLAKGKVANTNVT HHHHHCCCCCCCCEE	37.15	28112733
190	Sumoylation	LQALRGTKVAVNQRS HHHHCCCEEEECCCC	30.90	28112733
259	Phosphorylation	AGADTLKTLGSHMSQ CCHHHHHHHHHHHHH	39.19	30243723
262	Phosphorylation	DTLKTLGSHMSQQVS HHHHHHHHHHHHHHH	21.09	30243723
265	Phosphorylation	KTLGSHMSQQVSAAV HHHHHHHHHHHHHHH	16.43	30243723
269	Phosphorylation	SHMSQQVSAAVALLS HHHHHHHHHHHHHHH	13.23	22210691
276	Phosphorylation	SAAVALLSQKAGSQG HHHHHHHHHHHCCCC	30.41	30243723
285	Phosphorylation	KAGSQGLSLDALKQA HHCCCCCCHHHHHHC	30.90	22210691
290	Sumoylation	GLSLDALKQAKLPHA CCCHHHHHHCCCCCC	50.35	28112733
307	Phosphorylation	PSATSSLSPGLAPFT CCCCCCCCCCCCCEE	20.90	21406692
316	Sumoylation	GLAPFTLKPDGTRVL CCCCEEECCCCCEEC	37.70	28112733
316 (in isoform 2)	Sumoylation	-	37.70	-
372	Sumoylation	NISAVDVKPKDEAAL CCCEEECCCCCHHHH	41.72	28112733
374	Sumoylation	SAVDVKPKDEAALYK CEEECCCCCHHHHHH	63.58	28112733
374 (in isoform 2)	Sumoylation	-	63.58	-
393	Phosphorylation	YCSKVFGTDSSLQIH CHHHHHCCCCCEEEE	22.65	-
395	Phosphorylation	SKVFGTDSSLQIHLR HHHHCCCCCEEEEEE	32.55	-
401 (in isoform 2)	Sumoylation	-	6.84	-
405	Phosphorylation	QIHLRSHTGERPFVC EEEEECCCCCCCEEE	41.82	28555341
436	Sumoylation	FHRHPQVKANPQLFA EECCCCCCCCHHHHH	36.88	28112733
499	Phosphorylation	GTNPKDLTGGSLPGD CCCCCCCCCCCCCCC	50.02	21406692
502	Phosphorylation	PKDLTGGSLPGDLQP CCCCCCCCCCCCCCC	32.51	21406692
512	Phosphorylation	GDLQPGPSPESEGGP CCCCCCCCCCCCCCC	47.41	21406692
515	Phosphorylation	QPGPSPESEGGPTLP CCCCCCCCCCCCCCC	44.95	21406692
520	Phosphorylation	PESEGGPTLPGVGPN CCCCCCCCCCCCCCC	49.19	21406692
528	Phosphorylation	LPGVGPNYNSPRAGG CCCCCCCCCCCCCCC	21.83	21406692
530	Phosphorylation	GVGPNYNSPRAGGFQ CCCCCCCCCCCCCCC	12.85	18669648
539	Phosphorylation	RAGGFQGSGTPEPGS CCCCCCCCCCCCCCC	28.80	29888752
541	Phosphorylation	GGFQGSGTPEPGSET CCCCCCCCCCCCCHH	26.61	19664994
546	Phosphorylation	SGTPEPGSETLKLQQ CCCCCCCCHHHHHHH	37.82	29888752
548	Phosphorylation	TPEPGSETLKLQQLV CCCCCCHHHHHHHHH	30.78	21406692
550	Sumoylation	EPGSETLKLQQLVEN CCCCHHHHHHHHHHC	52.23	28112733
576	Phosphorylation	LICHRVLSCQSSLKM CHHHHHHHCCCCCEE	13.78	25159151
585	Phosphorylation	QSSLKMHYRTHTGER CCCCEEEEECCCCCC	17.44	22210691
587	Phosphorylation	SLKMHYRTHTGERPF CCEEEEECCCCCCCE	19.34	28348404
589	Phosphorylation	KMHYRTHTGERPFQC EEEEECCCCCCCEEC	39.87	28348404
597	Sumoylation	GERPFQCKICGRAFS CCCCEECEECCCEEE	30.19	28112733
623	Sumoylation	HRTNTSIKTQHSCPI ECCCCCCCCCCCCCC	41.73	28112733
710	Phosphorylation	SSSSKVPTPLPSIHS CCCCCCCCCCCCCCC	40.21	21406692
714	Phosphorylation	KVPTPLPSIHSASPT CCCCCCCCCCCCCCC	40.39	21406692
717	Phosphorylation	TPLPSIHSASPTLGF CCCCCCCCCCCCCCE	28.86	21406692
719	Phosphorylation	LPSIHSASPTLGFAM CCCCCCCCCCCCEEE	22.79	21406692
721	Phosphorylation	SIHSASPTLGFAMMA CCCCCCCCCCEEEEC	36.70	21406692
729	Phosphorylation	LGFAMMASLDAPGKV CCEEEECCCCCCCCC	14.64	21406692
748	Phosphorylation	FNLQRQGSRENGSVE CCCCCCCCCCCCCCC	28.25	21406692
753	Phosphorylation	QGSRENGSVESDGLT CCCCCCCCCCCCCCC	34.00	30576142
756	Phosphorylation	RENGSVESDGLTNDS CCCCCCCCCCCCCCH	34.52	21406692
760	Phosphorylation	SVESDGLTNDSSSLM CCCCCCCCCCHHHHC	42.37	21406692
763	Phosphorylation	SDGLTNDSSSLMGDQ CCCCCCCHHHHCCCH	24.72	21406692
764	Phosphorylation	DGLTNDSSSLMGDQE CCCCCCHHHHCCCHH	30.29	21406692
765	Phosphorylation	GLTNDSSSLMGDQEY CCCCCHHHHCCCHHH	26.74	21406692
772	Phosphorylation	SLMGDQEYQSRSPDI HHCCCHHHHHCCCCH	13.22	21406692
774	Phosphorylation	MGDQEYQSRSPDILE CCCHHHHHCCCCHHH	33.55	21406692
776	Phosphorylation	DQEYQSRSPDILETT CHHHHHCCCCHHHCC	31.97	28387310
782	Phosphorylation	RSPDILETTSFQALS CCCCHHHCCCEEECC	25.05	29888752
783	Phosphorylation	SPDILETTSFQALSP CCCHHHCCCEEECCC	20.40	29888752
784	Phosphorylation	PDILETTSFQALSPA CCHHHCCCEEECCCC	23.84	29888752
789	Phosphorylation	TTSFQALSPANSQAE CCCEEECCCCHHHHH	25.61	28387310
793	Phosphorylation	QALSPANSQAESIKS EECCCCHHHHHHHHH	32.64	29888752
797	Phosphorylation	PANSQAESIKSKSPD CCHHHHHHHHHHCCC	38.03	21406692
823	Phosphorylation	RTEMEGRSSLPSTFI CCCCCCCCCCCCCCE	47.27	21406692
824	Phosphorylation	TEMEGRSSLPSTFIR CCCCCCCCCCCCCEE	42.83	30576142
827	Phosphorylation	EGRSSLPSTFIRAPP CCCCCCCCCCEECCC	41.04	30576142
828	Phosphorylation	GRSSLPSTFIRAPPT CCCCCCCCCEECCCC	22.57	30576142
836	Phosphorylation	FIRAPPTYVKVEVPG CEECCCCEEEEECCC	12.21	30576142
838	Sumoylation	RAPPTYVKVEVPGTF ECCCCEEEEECCCCE	23.43	28112733
844	Phosphorylation	VKVEVPGTFVGPSTL EEEECCCCEECCCCC	14.74	21406692
849	Phosphorylation	PGTFVGPSTLSPGMT CCCEECCCCCCCCCC	35.73	21406692
850	Phosphorylation	GTFVGPSTLSPGMTP CCEECCCCCCCCCCH	34.10	21406692
852	Phosphorylation	FVGPSTLSPGMTPLL EECCCCCCCCCCHHH	21.35	21406692
856	Phosphorylation	STLSPGMTPLLAAQP CCCCCCCCHHHHCCC	19.39	21406692
873	Phosphorylation	QAKQHGCTRCGKNFS HHHHHCCCCCCCCCC	33.32	-
880	Phosphorylation	TRCGKNFSSASALQI CCCCCCCCCCCHHEE	34.09	-
881	Phosphorylation	RCGKNFSSASALQIH CCCCCCCCCCHHEEC	23.31	-
883	Phosphorylation	GKNFSSASALQIHER CCCCCCCCHHEECCC	31.31	28555341
891	Phosphorylation	ALQIHERTHTGEKPF HHEECCCCCCCCCCE	22.32	21406692
893	Phosphorylation	QIHERTHTGEKPFVC EECCCCCCCCCCEEE	46.56	21406692
896	Sumoylation	ERTHTGEKPFVCNIC CCCCCCCCCEEEEEC	45.13	28112733
917	Phosphorylation	KGNLKVHYMTHGANN CCCEEEEEECCCCCC	13.49	25003641
932	Sumoylation	NSARRGRKLAIENTM CHHHHHHHHHHHCHH	45.13	28112733
944	Phosphorylation	NTMALLGTDGKRVSE CHHHHHCCCCCCHHH	41.36	22210691
947	Sumoylation	ALLGTDGKRVSEIFP HHHCCCCCCHHHHCC	53.06	28112733
950	Phosphorylation	GTDGKRVSEIFPKEI CCCCCCHHHHCCHHH	29.07	28555341
984	Phosphorylation	NGGLAVKTNEISVIQ CCCEEEECCEEEEEE	31.33	22210691
988	Phosphorylation	AVKTNEISVIQSGGV EEECCEEEEEECCCC	13.64	22210691
1005	Phosphorylation	LPVSLGATSVVNNAT CCCEECCEEEECCEE	21.91	22210691
1019	Phosphorylation	TVSKMDGSQSGISAD EEEECCCCCCCCCCC	19.53	28112733
1021	Phosphorylation	SKMDGSQSGISADVE EECCCCCCCCCCCCC	39.53	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CRBN	Q96SW2	PMID:32071327

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SALL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SALL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PO5F1_HUMAN	POU5F1	physical	19060217
NANOG_HUMAN	NANOG	physical	19060217

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607323: Duane-radial ray syndrome (DRRS)
• 147750: Oculootoradial syndrome (OORS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.