| UniProt ID | TEAD2_HUMAN | |
|---|---|---|
| UniProt AC | Q15562 | |
| Protein Name | Transcriptional enhancer factor TEF-4 | |
| Gene Name | TEAD2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 447 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.. | |
| Protein Sequence | MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 67 | Ubiquitination | YPPCGRRKIILSDEG CCCCCCCEEEECCCC | 32.51 | - | |
| 71 | Phosphorylation | GRRKIILSDEGKMYG CCCEEEECCCCCEEC | 24.17 | 30266825 | |
| 75 | Ubiquitination | IILSDEGKMYGRNEL EEECCCCCEECHHHH | 27.22 | 21890473 | |
| 75 | Ubiquitination | IILSDEGKMYGRNEL EEECCCCCEECHHHH | 27.22 | 21890473 | |
| 75 | Ubiquitination | IILSDEGKMYGRNEL EEECCCCCEECHHHH | 27.22 | 21890473 | |
| 86 | Phosphorylation | RNELIARYIKLRTGK HHHHHHHHHHHHCCC | 8.06 | 21403953 | |
| 93 | Methylation | YIKLRTGKTRTRKQV HHHHHCCCCCCHHHH | 33.93 | - | |
| 98 | Ubiquitination | TGKTRTRKQVSSHIQ CCCCCCHHHHHHHHH | 55.21 | - | |
| 112 | Phosphorylation | QVLARRKSREIQSKL HHHHHHHHHHHHHHH | 33.08 | - | |
| 117 | Phosphorylation | RKSREIQSKLKDQVS HHHHHHHHHHHHHHC | 45.69 | - | |
| 125 | Ubiquitination | KLKDQVSKDKAFQTM HHHHHHCHHHHHHHH | 65.47 | 21906983 | |
| 127 | Ubiquitination | KDQVSKDKAFQTMAT HHHHCHHHHHHHHHH | 55.63 | 2190698 | |
| 131 | Phosphorylation | SKDKAFQTMATMSSA CHHHHHHHHHHHCHH | 11.43 | - | |
| 255 | Phosphorylation | RHLFVHISQHCPSPG HHHHEEHHHCCCCCC | 10.05 | 29255136 | |
| 260 | Phosphorylation | HISQHCPSPGAPPLE EHHHCCCCCCCCCCC | 41.16 | 25849741 | |
| 264 | Phosphorylation | HCPSPGAPPLESVDV CCCCCCCCCCCCCCH | 39.67 | 27251275 | |
| 268 | Phosphorylation | PGAPPLESVDVRQIY CCCCCCCCCCHHHHH | 31.16 | 29255136 | |
| 275 | Phosphorylation | SVDVRQIYDKFPEKK CCCHHHHHHHCCHHC | 12.54 | - | |
| 277 | Ubiquitination | DVRQIYDKFPEKKGG CHHHHHHHCCHHCCC | 45.94 | - | |
| 323 | Phosphorylation | GAGGSISSGGFYGVS CCCCCCCCCCCCCCC | 41.06 | 30576142 | |
| 330 | Phosphorylation | SGGFYGVSSQYESLE CCCCCCCCCCCCCCC | 13.83 | 30576142 | |
| 331 | Phosphorylation | GGFYGVSSQYESLEH CCCCCCCCCCCCCCC | 34.08 | 30576142 | |
| 348 | S-palmitoylation | LTCSSKVCSFGKQVV EEECCCCHHHCHHHH | 2.99 | 26900866 | |
| 352 | Ubiquitination | SKVCSFGKQVVEKVE CCCHHHCHHHHHHHH | 37.60 | - | |
| 380 | S-palmitoylation | RLLRSPMCEYLVNFL HHHHCHHHHHHHHHH | 3.36 | 26900866 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TEAD2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TEAD2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TEAD2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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