ZN536_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN536_HUMAN
• UniProt AC: O15090
• Protein Name: Zinc finger protein 536
• Gene Name: ZNF536
• Organism: Homo sapiens (Human).
• Sequence Length: 1300
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'..
• Protein Sequence: MEEASLCLGVSSAEPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKPPASLEEKAHVPMSGQPMGSQMALLANQLGREVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQLKGSLLQPRPDLKPPPHAQQAPLAACTLALQANHSVPDVAHPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMTPDKAGLSEPSQLYGKGELPMKEKEALGKLLSPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHPLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGSQRDLPSKLDPLESSRDFLSHGLNQTLEYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGEEDGLHVGLDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPDILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNFQGSLQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSALSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASSTANSGCIKRPDLCGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEEASLCLGVSS ---CCCCCEEECCCC	23.93	-
151	Phosphorylation	ILSLHMRTHTGEKPF CEEEEECCCCCCCCC	19.06	23312004
153	Phosphorylation	SLHMRTHTGEKPFKC EEEECCCCCCCCCCC	46.56	29496963
211	Ubiquitination	ERAILRDKQLKGSLL HHHHHCCCCCCCCCC	51.61	29967540
257	Phosphorylation	DVAHPVPSPKPASVQ CCCCCCCCCCCCCCC	45.87	24719451
405	Phosphorylation	KLSVKNKSPSDPEVP HCCCCCCCCCCCCCC	38.74	23403867
407	Phosphorylation	SVKNKSPSDPEVPVP CCCCCCCCCCCCCCC	73.26	23403867
419	Phosphorylation	PVPMGGMSQEAHANL CCCCCCCCHHHHHHH	28.30	29978859
427	Phosphorylation	QEAHANLYSRYLSCL HHHHHHHHHHHHHHH	7.30	23403867
428	Phosphorylation	EAHANLYSRYLSCLQ HHHHHHHHHHHHHHH	20.02	24719451
436	Phosphorylation	RYLSCLQSGFMTPDK HHHHHHHHCCCCCCC	22.50	27732954
440	Phosphorylation	CLQSGFMTPDKAGLS HHHHCCCCCCCCCCC	26.52	27732954
596	Phosphorylation	GSQRDLPSKLDPLES CCCCCCCCCCCCCHH	53.82	24719451
631	Phosphorylation	GNMKEKPTECPDCGR CCCCCCCCCCCCHHH	62.38	28787133
674	Phosphorylation	GLDERRGSGSDQESQ CCCCCCCCCCCCCCC	33.06	22496350
676	Phosphorylation	DERRGSGSDQESQSV CCCCCCCCCCCCCCC	37.51	20363803
680	Phosphorylation	GSGSDQESQSVSRST CCCCCCCCCCCCCCC	23.32	-
682	Phosphorylation	GSDQESQSVSRSTTP CCCCCCCCCCCCCCC	31.19	27732954
684	Phosphorylation	DQESQSVSRSTTPGS CCCCCCCCCCCCCCC	26.26	27732954
774	Phosphorylation	KVHLRIHTGEKPYKC EEEEEEECCCCCCCC	44.67	29496963
826	Phosphorylation	QDHKDEMSSKASLFI CCCCHHHHHHHHEEC	27.00	22817900
827	Phosphorylation	DHKDEMSSKASLFIR CCCHHHHHHHHEECC	30.82	22817900
874	Phosphorylation	GDHSGQATGMSSEVP CCCCCCCCCCCCCCC	26.06	-
892	Phosphorylation	LKGTDLPSKSTHFSE HCCCCCCCCCCCHHH	46.68	24719451
928	Phosphorylation	FMDSFVLSSLKKEKD HHHHHHHHHHHHHHH	28.46	24719451
967	Acetylation	SGKSSQRKSEKSQYE CCCCCCCCCCCCCCC	56.16	7365035
973	Phosphorylation	RKSEKSQYEPLDLSV CCCCCCCCCCCCCCC	26.97	-
1042	Ubiquitination	IGVTVNCKDQAREAS EEEEEECHHHHHHHH	47.90	-
1093	Phosphorylation	ETLGEQKSGAWTGHV HHHCCCCCCCCCCCC	33.18	22468782
1097	Phosphorylation	EQKSGAWTGHVDPAF CCCCCCCCCCCCHHH	19.51	22468782
1109	Phosphorylation	PAFCNFPSDFYKQFG HHHCCCCHHHHHHHC	35.89	22468782
1141	Phosphorylation	EPDGKAHSEEDVPIL CCCCCCCCCCCCCEE	47.76	29255136
1162	Phosphorylation	KNTTDDLSDIASSED CCCCCCHHHHHCCCC	33.68	25921289
1166	Phosphorylation	DDLSDIASSEDMDSS CCHHHHHCCCCCCCC	34.30	25921289
1167	Phosphorylation	DLSDIASSEDMDSSK CHHHHHCCCCCCCCC	28.70	25921289
1172	Phosphorylation	ASSEDMDSSKGENND HCCCCCCCCCCCCCC	27.58	25921289
1201	Phosphorylation	LSALSKDSSSDGGDS HHHHCCCCCCCCCCC	35.16	27732954
1202	Phosphorylation	SALSKDSSSDGGDSL HHHCCCCCCCCCCCC	42.45	27732954
1203	Phosphorylation	ALSKDSSSDGGDSLQ HHCCCCCCCCCCCCC	44.20	27732954
1208	Phosphorylation	SSSDGGDSLQPTGTS CCCCCCCCCCCCCCC	31.98	27732954
1223	Phosphorylation	QPVQGLVSPLSQAPE CCCCHHCCCHHHCCH	25.76	27732954
1226	Phosphorylation	QGLVSPLSQAPEKQW CHHCCCHHHCCHHHH	27.90	27732954
1266	Phosphorylation	DKPMNMLSVLRAYSS CCCCHHHHHHHHHCC	14.34	24719451
1266	O-linked_Glycosylation	DKPMNMLSVLRAYSS CCCCHHHHHHHHHCC	14.34	30379171

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN536_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN536_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN536_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN536_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-827, ANDMASS SPECTROMETRY.
PubMed: 19690332