dbPTM

SMAL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMAL1_HUMAN
UniProt AC	Q9NZC9
Protein Name	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Gene Name	SMARCAL1
Organism	Homo sapiens (Human).
Sequence Length	954
Subcellular Localization	Nucleus . Recruited to damaged DNA regions.
Protein Description	ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks..
Protein Sequence	MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGPSQNFPRESCKPVSHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEEMPTACPGHSPRSQMALTGISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQKGKCVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQAGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEAAESFDPGSASGTSGSSSQNMGDTLDESSLTASPQKKRRFEFFDNWDSFTSPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLPLTEEQ ------CCCCCCHHH	38.40	-
2	Acetylation	------MSLPLTEEQ ------CCCCCCHHH	38.40	22814378
37	Phosphorylation	AEQHQRTSSGTSIAG HHHHHHCCCCCCCCC	29.03	25159151
38	Phosphorylation	EQHQRTSSGTSIAGN HHHHHCCCCCCCCCC	45.54	25159151
40	Phosphorylation	HQRTSSGTSIAGNPF HHHCCCCCCCCCCCC	20.93	28555341
63	Acetylation	NFPRESCKPVSHGVI CCCHHHCCCCCCCEE	58.70	25953088
72	Methylation	VSHGVIFKQQNLSSS CCCCEEEEECCCCCC	39.59	115980939
78	Phosphorylation	FKQQNLSSSSNADQR EEECCCCCCCCCCCC	40.74	28555341
79	Phosphorylation	KQQNLSSSSNADQRP EECCCCCCCCCCCCC	25.00	28555341
106	Phosphorylation	KKPEEMPTACPGHSP CCHHHCCCCCCCCCC	39.31	23403867
112	Phosphorylation	PTACPGHSPRSQMAL CCCCCCCCCHHHHHH	28.11	23401153
115	Phosphorylation	CPGHSPRSQMALTGI CCCCCCHHHHHHCCC	27.91	26074081
120	Phosphorylation	PRSQMALTGISPPLA CHHHHHHCCCCCCHH	23.96	22199227
123	Phosphorylation	QMALTGISPPLAQSP HHHHCCCCCCHHCCC	23.08	25159151
129	Phosphorylation	ISPPLAQSPPEVPKQ CCCCHHCCCCCCCHH	36.49	25159151
140	Phosphorylation	VPKQQLLSYELGQGH CCHHHHHHHCCCCCC	25.75	28450419
141	Phosphorylation	PKQQLLSYELGQGHA CHHHHHHHCCCCCCC	18.36	28450419
146	Ubiquitination	LSYELGQGHAQASPE HHHCCCCCCCCCCCC	19.12	22817900
151	Phosphorylation	GQGHAQASPEIRFTP CCCCCCCCCCCEECC	15.81	23401153
165	Acetylation	PFANPTHKPLAKPKS CCCCCCCCCCCCCCC	44.18	25953088
169	Ubiquitination	PTHKPLAKPKSSQET CCCCCCCCCCCCCCC	61.74	29967540
172	Phosphorylation	KPLAKPKSSQETPAH CCCCCCCCCCCCCCC	45.86	25849741
173	Phosphorylation	PLAKPKSSQETPAHS CCCCCCCCCCCCCCC	37.86	25849741
176	Phosphorylation	KPKSSQETPAHSSGQ CCCCCCCCCCCCCCC	20.38	27732954
180	Phosphorylation	SQETPAHSSGQPPRD CCCCCCCCCCCCCCC	37.97	23186163
181	Phosphorylation	QETPAHSSGQPPRDA CCCCCCCCCCCCCCC	31.42	22817900
194	Phosphorylation	DAKLEAKTAKASPSG CCHHHHHCCCCCCCC	40.20	27174698
198	Phosphorylation	EAKTAKASPSGQNIS HHHCCCCCCCCCCCE	20.92	11799392
200	Phosphorylation	KTAKASPSGQNISYI HCCCCCCCCCCCEEE	50.98	29496963
205	Phosphorylation	SPSGQNISYIHSSSE CCCCCCCEEEECCCC	26.11	29978859
206	Phosphorylation	PSGQNISYIHSSSES CCCCCCEEEECCCCC	10.00	29978859
211	Phosphorylation	ISYIHSSSESVTPRT CEEEECCCCCCCCCC	36.58	-
215	Phosphorylation	HSSSESVTPRTEGRL ECCCCCCCCCCCCCC	19.14	25159151
225	Ubiquitination	TEGRLQQKSGSSVQK CCCCCCCCCCCCCCC	43.77	29967540
232	Ubiquitination	KSGSSVQKGVNSQKG CCCCCCCCCCCCCCC	63.77	29967540
267	Phosphorylation	AVFKTLPSKNYDPDT EEEECCCCCCCCCCC	36.32	24719451
268	Ubiquitination	VFKTLPSKNYDPDTK EEECCCCCCCCCCCC	58.55	29967540
269	Ubiquitination	FKTLPSKNYDPDTKT EECCCCCCCCCCCCC	51.26	24816145
275	Ubiquitination	KNYDPDTKTWNFSMN CCCCCCCCCEECCHH	59.95	-
306	Phosphorylation	LQPLEWAYGSSESPS CEECCCCCCCCCCCC	20.72	28348404
308	Phosphorylation	PLEWAYGSSESPSTS ECCCCCCCCCCCCCC	20.46	28348404
309	Phosphorylation	LEWAYGSSESPSTSS CCCCCCCCCCCCCCC	37.42	28348404
311	Phosphorylation	WAYGSSESPSTSSEG CCCCCCCCCCCCCCC	26.54	28348404
313	Phosphorylation	YGSSESPSTSSEGQA CCCCCCCCCCCCCCC	50.64	28348404
314	Phosphorylation	GSSESPSTSSEGQAG CCCCCCCCCCCCCCC	39.39	28348404
315	Phosphorylation	SSESPSTSSEGQAGL CCCCCCCCCCCCCCC	30.63	28348404
316	Phosphorylation	SESPSTSSEGQAGLP CCCCCCCCCCCCCCC	45.92	28348404
411	Ubiquitination	AFASQLKKTSLSLTP HHHHHHHHCCCCCCC	52.52	29967540
431	Ubiquitination	DLSEVDPKLVSNLMP HHHHCCHHHHHHCCC	57.99	29967540
450	Ubiquitination	GVNFAIAKGGRLLLA CCCEEEEECCEEEEE	56.64	22817900
460	Sulfoxidation	RLLLADDMGLGKTIQ EEEEECCCCCCHHHH	4.99	21406390
528	Phosphorylation	AGLINIVSFDLLSKL HHHHHHHCHHHHHHH	14.83	-
533	Phosphorylation	IVSFDLLSKLEKQLK HHCHHHHHHHHHHHC	42.36	-
555	Ubiquitination	IDESHFLKNSRTARC ECCHHHHCCCCHHHH	52.51	29967540
570	Ubiquitination	RAAMPVLKVAKRVIL HHHHHHHHHHHEEHH	40.14	-
573	Ubiquitination	MPVLKVAKRVILLSG HHHHHHHHEEHHHCC	50.62	24816145
579	Phosphorylation	AKRVILLSGTPAMSR HHEEHHHCCCCCCCC	36.86	22210691
581	Phosphorylation	RVILLSGTPAMSRPA EEHHHCCCCCCCCCH	12.42	22210691
627	Phosphorylation	WGWDYSGSSNLGELK CCCCCCCCCCHHHHH	15.31	-
647	Ubiquitination	AVMLRRLKSDVLSQL HHHHHHHHHHHHHCC	42.68	29967540
652	Phosphorylation	RLKSDVLSQLPAKQR HHHHHHHHCCCCCCC	29.53	-
657	Ubiquitination	VLSQLPAKQRKIVVI HHHCCCCCCCCEEEE	49.01	29967540
660	Ubiquitination	QLPAKQRKIVVIAPG CCCCCCCCEEEECCC	37.04	29967540
682	Ubiquitination	AALDAAAKEMTTKDK HHHHHHHHHCCCCCH	43.20	29967540
712	Phosphorylation	TAEAKIPSVIEYILD CHHHCCCHHHHHHHH	38.92	29449344
716	Phosphorylation	KIPSVIEYILDLLES CCCHHHHHHHHHHHH	8.82	29449344
723	Phosphorylation	YILDLLESGREKFLV HHHHHHHHCHHHEEE	43.02	29449344
849	Ubiquitination	LWPLIQEKIKVLAEA HHHHHHHHHHHHHHC	31.30	29967540
851	Ubiquitination	PLIQEKIKVLAEAGL HHHHHHHHHHHHCCC	42.11	-
859	Phosphorylation	VLAEAGLSETNFSEM HHHHCCCCCCCHHHH	41.27	20068231
861	Phosphorylation	AEAGLSETNFSEMTE HHCCCCCCCHHHHHC	37.88	20068231
864	Phosphorylation	GLSETNFSEMTESTD CCCCCCHHHHHCCCC	28.64	20068231
867	Phosphorylation	ETNFSEMTESTDYLY CCCHHHHHCCCCCCC	23.80	20068231
869	Phosphorylation	NFSEMTESTDYLYKD CHHHHHCCCCCCCCC	19.88	20068231
870	Phosphorylation	FSEMTESTDYLYKDP HHHHHCCCCCCCCCH	23.56	20068231
872	Phosphorylation	EMTESTDYLYKDPKQ HHHCCCCCCCCCHHH	16.42	20068231
874	Phosphorylation	TESTDYLYKDPKQQK HCCCCCCCCCHHHHH	13.71	20068231
881	Ubiquitination	YKDPKQQKIYDLFQK CCCHHHHHHHHHHHH	40.51	29967540
883	Phosphorylation	DPKQQKIYDLFQKSF CHHHHHHHHHHHHHH	17.40	27642862
888	Ubiquitination	KIYDLFQKSFEKEGS HHHHHHHHHHHCCCC	50.18	29967540
889	Phosphorylation	IYDLFQKSFEKEGSD HHHHHHHHHHCCCCH	28.05	29978859
895	Phosphorylation	KSFEKEGSDMELLEA HHHHCCCCHHHHHHH	34.57	26471730
905	Phosphorylation	ELLEAAESFDPGSAS HHHHHHHHCCCCCCC	30.17	30576142
910	Phosphorylation	AESFDPGSASGTSGS HHHCCCCCCCCCCCC	25.34	30576142
912	Phosphorylation	SFDPGSASGTSGSSS HCCCCCCCCCCCCCC	44.28	26471730
914	Phosphorylation	DPGSASGTSGSSSQN CCCCCCCCCCCCCCC	27.67	26471730
915	Phosphorylation	PGSASGTSGSSSQNM CCCCCCCCCCCCCCC	39.96	26471730
917	Phosphorylation	SASGTSGSSSQNMGD CCCCCCCCCCCCCCC	26.95	26471730
918	Phosphorylation	ASGTSGSSSQNMGDT CCCCCCCCCCCCCCC	39.20	26471730
919	Phosphorylation	SGTSGSSSQNMGDTL CCCCCCCCCCCCCCC	27.54	30576142
925	Phosphorylation	SSQNMGDTLDESSLT CCCCCCCCCCHHHCC	30.31	30377224
929	Phosphorylation	MGDTLDESSLTASPQ CCCCCCHHHCCCCCH	30.25	30108239
930	Phosphorylation	GDTLDESSLTASPQK CCCCCHHHCCCCCHH	27.91	30108239
932	Phosphorylation	TLDESSLTASPQKKR CCCHHHCCCCCHHHH	27.34	30108239
934	Phosphorylation	DESSLTASPQKKRRF CHHHCCCCCHHHHCC	23.72	30108239
949	Phosphorylation	EFFDNWDSFTSPL-- CCCCCCHHCCCCC--	23.26	28348404
951	Phosphorylation	FDNWDSFTSPL---- CCCCHHCCCCC----	33.13	27732954
952	Phosphorylation	DNWDSFTSPL----- CCCHHCCCCC-----	23.38	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
652	S	Phosphorylation	Kinase	ATR	Q13535	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SMAL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMAL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ST1A1_HUMAN	SULT1A1	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
242900	Schimke immuno-osseous dysplasia (SIOD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMAL1_HUMAN

Related Literatures of Post-Translational Modification