PCD15_HUMAN - dbPTM
PCD15_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCD15_HUMAN
UniProt AC Q96QU1
Protein Name Protocadherin-15
Gene Name PCDH15
Organism Homo sapiens (Human).
Sequence Length 1955
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Efficient localization to the plasma membrane requires the presence of LHFPL5..
Isoform 3: Secreted.
Protein Description Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function..
Protein Sequence MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52N-linked_GlycosylationAIDEESRNGTILVDN
EECCCCCCCEEEEEC		62.33UniProtKB CARBOHYD
97N-linked_GlycosylationVKQMLFLNSTGRVLD
HHHHHEECCCCCCCC		30.14UniProtKB CARBOHYD
144PhosphorylationVRDRNDNSPTFKHES
EECCCCCCCCCCCCE		28.3423828894
146PhosphorylationDRNDNSPTFKHESYY
CCCCCCCCCCCCEEE		45.1724719451
201N-linked_GlycosylationNPDDPTSNDTFEIPL
CCCCCCCCCCEEEEE		55.61UniProtKB CARBOHYD
348PhosphorylationHPRTAELSLLEPVNR
CCCCCCCCEEECCCC		23.55-
399PhosphorylationSPYFTMPSYQGYILE
CCCEECCCCCCEEEC		21.1826434776
400PhosphorylationPYFTMPSYQGYILES
CCEECCCCCCEEECC		10.4926434776
403PhosphorylationTMPSYQGYILESAPV
ECCCCCCEEECCCCC		6.1926434776
407PhosphorylationYQGYILESAPVGATI
CCCEEECCCCCCCEE		34.1326434776
413PhosphorylationESAPVGATISDSLNL
CCCCCCCEECCCCCC		18.3226434776
415PhosphorylationAPVGATISDSLNLTS
CCCCCEECCCCCCCC		19.4526434776
417PhosphorylationVGATISDSLNLTSPL
CCCEECCCCCCCCCC		16.6226434776
419N-linked_GlycosylationATISDSLNLTSPLRI
CEECCCCCCCCCCEE		45.27UniProtKB CARBOHYD
421PhosphorylationISDSLNLTSPLRIVA
ECCCCCCCCCCEEEE		27.5026434776
422PhosphorylationSDSLNLTSPLRIVAL
CCCCCCCCCCEEEEE		25.7126434776
559N-linked_GlycosylationAQGDFIINKTTGLIT
CCCCEEEECCCCCEE		30.70UniProtKB CARBOHYD
579PhosphorylationEMIVGRTYALTVQAA
EEEECCEEEEEEEEC		9.7618083107
600PhosphorylationERRNSICTVYIEVLP
HHCCCEEEEEEEECC		18.0522210691
602PhosphorylationRNSICTVYIEVLPPN
CCCEEEEEEEECCCC		3.5322210691
641PhosphorylationVLLNLQATDREGDSI
EEEECEEECCCCCEE		23.7222210691
649PhosphorylationDREGDSITYAIENGD
CCCCCEEEEEECCCC		15.7325690035
662N-linked_GlycosylationGDPQRVFNLSETTGI
CCCCEEEECCCCCCE		39.54UniProtKB CARBOHYD
724N-linked_GlycosylationFDPYLPRNLSVVEEE
CCCCCCCCCCHHHHH		34.43UniProtKB CARBOHYD
768N-linked_GlycosylationNLFRITSNGSIYTAV
CCEEECCCCCEEEEE		39.31UniProtKB CARBOHYD
821N-linked_GlycosylationDNSPVFTNSTYTVLV
CCCCCCCCCEEEEEE		22.38UniProtKB CARBOHYD
851N-linked_GlycosylationKDVDLGANVSYRIRS
EECCCCCCEEEEECC		22.82UniProtKB CARBOHYD
858PhosphorylationNVSYRIRSPEVKHFF
CEEEEECCCCCCEEE		24.0425921289
974PhosphorylationVDDVQFPYPASIFEV
ECCCCCCCCCCEEEE		16.8430108239
977PhosphorylationVQFPYPASIFEVEED
CCCCCCCCEEEEEEC		24.2530108239
1064N-linked_GlycosylationVISAAAINQSIVYSI
HEEHHHHCCEEEEEE		25.48UniProtKB CARBOHYD
1084N-linked_GlycosylationEDTFGINNITGVIYV
CCCCCEECEEEEEEE		31.14UniProtKB CARBOHYD
1149PhosphorylationPVFQKKFYIGGVSED
CCEECEEEECCCCHH		13.92-
1175N-linked_GlycosylationATDKDTGNYSVMAYR
EECCCCCCEEEEEEE		28.18UniProtKB CARBOHYD
1181PhosphorylationGNYSVMAYRLIIPPI
CCEEEEEEEEEECCC		6.45-
1216PhosphorylationLFHNMRRSYFKFQVI
HHHHHCHHCCCEEEE		25.2629083192
1217PhosphorylationFHNMRRSYFKFQVIA
HHHHCHHCCCEEEEE		14.6929083192
1225PhosphorylationFKFQVIATDDYGKGL
CCEEEEEECCCCCCC		20.4829083192
1228PhosphorylationQVIATDDYGKGLSGK
EEEEECCCCCCCCCC		24.4429083192
1501PhosphorylationKSAHVDGSLKSNKLK
HHHCCCCCCCCCCCC		28.32-
1507 (in isoform 6)Phosphorylation-6.57-
1517PhosphorylationARKFTFLSDEDDLSA
CCEEEECCCCCCHHC		34.46-
1529PhosphorylationLSAHNPLYKENISQV
HHCCCHHHHCCHHHC		19.95-
1553PhosphorylationTDFVDPFSPKIQAKS
CCCCCCCCHHHHHHC		30.5824719451
1562PhosphorylationKIQAKSKSLRGPREK
HHHHHCCCCCCHHHH		30.32-
1577PhosphorylationIQRLWSQSVSLPRRL
HHHHHHCCCCCCHHH		14.25-
1579PhosphorylationRLWSQSVSLPRRLMR
HHHHCCCCCCHHHHC		37.5924945436
1622PhosphorylationCTNKRGSSNPLLTTE
CCCCCCCCCCCCCHH		45.34-
1626 (in isoform 4)Phosphorylation-6.17-
1630 (in isoform 4)Phosphorylation-40.54-
1637 (in isoform 4)Phosphorylation-53.04-
1648 (in isoform 4)Phosphorylation-46.20-
1680PhosphorylationTLPTVSRTVELKSEP
CCCCCEEEEEECCCC		15.7229978859
1685PhosphorylationSRTVELKSEPNVISS
EEEEEECCCCCCCCC		71.5529978859
1691PhosphorylationKSEPNVISSPAECSL
CCCCCCCCCCCEECE		26.4529978859
1692PhosphorylationSEPNVISSPAECSLE
CCCCCCCCCCEECEE		19.6029978859
1697PhosphorylationISSPAECSLELSPSR
CCCCCEECEEECCCC		19.1829978859
1701PhosphorylationAECSLELSPSRPCVL
CEECEEECCCCCEEE		16.0829978859
1703PhosphorylationCSLELSPSRPCVLHS
ECEEECCCCCEEEEC		45.5429978859
1887AcetylationKGILRHVKNLAELEK
CHHHHHHHHHHHHHH		39.877668793
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCD15_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCD15_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCD15_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PCD15_HUMAN !!
Drug and Disease Associations
Kegg Disease
OMIM Disease
602083Usher syndrome 1F (USH1F)
601067Usher syndrome 1D/F (USH1DF)
609533Deafness, autosomal recessive, 23 (DFNB23)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCD15_HUMAN

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Related Literatures of Post-Translational Modification

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