TF7L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF7L1_HUMAN
• UniProt AC: Q9HCS4
• Protein Name: Transcription factor 7-like 1
• Gene Name: TCF7L1
• Organism: Homo sapiens (Human).
• Sequence Length: 588
• Subcellular Localization: Nucleus.
• Protein Description: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance..
• Protein Sequence: MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	GGGGGGGSGGGGGSS CCCCCCCCCCCCCCC	37.22	28985074
77	Phosphorylation	VNESENQSSSSDSEA CCCCCCCCCCCCHHH	43.71	29888752
78	Phosphorylation	NESENQSSSSDSEAE CCCCCCCCCCCHHHH	24.89	29888752
79	Phosphorylation	ESENQSSSSDSEAER CCCCCCCCCCHHHHH	43.33	29888752
80	Phosphorylation	SENQSSSSDSEAERR CCCCCCCCCHHHHHC	47.29	28985074
82	Phosphorylation	NQSSSSDSEAERRPQ CCCCCCCHHHHHCCC	40.43	29888752
131	Phosphorylation	FLMIPDLSSPYLSNG EEECCCCCCCCCCCC	36.33	27251275
132	Phosphorylation	LMIPDLSSPYLSNGP EECCCCCCCCCCCCC	25.51	27251275
136	Phosphorylation	DLSSPYLSNGPLSPG CCCCCCCCCCCCCCC	33.62	28348404
141	Phosphorylation	YLSNGPLSPGGARTY CCCCCCCCCCCHHHH	25.32	28348404
169	Phosphorylation	ATVKDTRSPSPAHLS CCCCCCCCCCHHHHC	31.64	27794612
171	Phosphorylation	VKDTRSPSPAHLSNK CCCCCCCCHHHHCCC	35.65	24961811
176	Phosphorylation	SPSPAHLSNKVPVVQ CCCHHHHCCCCCCCC	25.41	27251275
285	Phosphorylation	ASMSSLVSSRFSPHM CCHHHHHHHCCCCCC	22.53	24719451
289	Phosphorylation	SLVSSRFSPHMVAPA HHHHHCCCCCCCCCC	16.88	28348404
312	Phosphorylation	IPHPAIVSPIVKQEP CCCCCEECCCCCCCC	11.64	24719451
323	Phosphorylation	KQEPAPPSLSPAVSV CCCCCCCCCCCCEEE	40.18	28348404
325	Phosphorylation	EPAPPSLSPAVSVKS CCCCCCCCCCEEECC	18.36	28985074
329	Phosphorylation	PSLSPAVSVKSPVTV CCCCCCEEECCCCCC	26.40	28348404
332	Phosphorylation	SPAVSVKSPVTVKKE CCCEEECCCCCCCCH	23.58	21406692
348	Ubiquitination	EKKPHVKKPLNAFML HCCCCCCCHHHHHHH	54.36	22505724
349	Ubiquitination	KKPHVKKPLNAFMLY CCCCCCCHHHHHHHH	25.73	22505724
358	Ubiquitination	NAFMLYMKEMRAKVV HHHHHHHHHHHHHHH	34.50	-
358	Acetylation	NAFMLYMKEMRAKVV HHHHHHHHHHHHHHH	34.50	-
363	Acetylation	YMKEMRAKVVAECTL HHHHHHHHHHHHCCC	27.20	-
373	Phosphorylation	AECTLKESAAINQIL HHCCCCHHHHHHHHH	22.78	22210691
394	Ubiquitination	LSREEQAKYYELARK CCHHHHHHHHHHHHH	48.32	24816145
395	Phosphorylation	SREEQAKYYELARKE CHHHHHHHHHHHHHH	12.75	-
395	Ubiquitination	SREEQAKYYELARKE CHHHHHHHHHHHHHH	12.75	24816145
396	Phosphorylation	REEQAKYYELARKER HHHHHHHHHHHHHHH	12.08	-
421	Ubiquitination	SARDNYGKKKKRKRE HHHCCCCHHHHHHHH	51.57	24816145
422	Ubiquitination	ARDNYGKKKKRKREK HHCCCCHHHHHHHHH	60.20	24816145
449	Phosphorylation	EAEGALASKSKKPCV HHHHHHHHCCCCCCC	38.01	-
488	Phosphorylation	TPSAALASPAAPAAT CHHHHHHCCCCCCCC	18.87	-
495	Phosphorylation	SPAAPAATHSEQAQP CCCCCCCCCCCCCCC	28.21	-
511	Phosphorylation	SLTTKPETRAQLALH CCCCCHHHHHHHHHH	39.57	-
519	Phosphorylation	RAQLALHSAAFLSAK HHHHHHHHHHHHHHH	23.34	-
524	Phosphorylation	LHSAAFLSAKAAASS HHHHHHHHHHHHHHC	22.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF7L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF7L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAZP2_HUMAN	DAZAP2	physical	19304756

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.